12-dimethylbenz(a)anthracene
EFFECT OF IRON OVERLOAD ON 7, 12-DIMETHYLBENZ (A) ANTHRACENE-INDUCED SKIN TUMORIGENESIS
... Iron overload is known to occur in the West European and American population due to the consumption of iron-rich diets. On the other hand, genetic disorders leading to iron overload are also known. Iron overload leads to ...
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PROTECTIVE EFFECT OF THYMOQUINONE ON THE LIVER TISSUES OF 7, 12 DIMETHYLBENZ (A) ANTHRACENE INDUCED EXPERIMENTAL BREAST CANCER RATS
... 7, 12-dimethylbenz (a) anthracene (DMBA) initiates the production of free radicals that induce carcinogenesis in rodents which mimic human cancers morphologically and histologically ...
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Anti-cell Proliferative, Anti-inflammatory and Anti-angiogenic Potential of Lupeol in 7,12-dimethylbenz(a) Anthracene Induced Hamster Buccal Pouch Carcinogenesis
... Aim: Diverse pharmacological and biochemical effects of lupeol have been reported earlier. The present study utilized the immune expression pattern of proliferating cellular nuclear antigen (PCNA), cyclin D1, vascular ...
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Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice
... TGF-ß potently inhibits cell proliferation. It also induces apoptosis in several cell types, such as breast epithelial cells. Accordingly, TGF-ß plays a major role in the inhibition of tumor formation during early stages ...
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PREVENTIVE EFFECTS OF PHOENIX DACTYLIFERA POLYPHENOLS AGAINST 7,12 DIMETHYLBENZ(A)ANTHRACENE INDUCED MAMMARY CANCER
... Vol 10, Issue 7, 2017 Online 2455 3891 Print 0974 2441 PREVENTIVE EFFECTS OF PHOENIX DACTYLIFERA POLYPHENOLS AGAINST 7,12 DIMETHYLBENZ(A)ANTHRACENE INDUCED MAMMARY CANCER RABAB OMRAN1*, ZAHRAA M AL TA[.] ...
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Obesity promotes 7,12 dimethylbenz(a)anthracene induced mammary tumor development in female zucker rats
... There has been only one study published that used female Zucker rats as a model to investigate the role of obesity in mammary tumor development [20]. That study used N-methyl- N-nitrosourea (MNU) as a carcinogen and ...
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SINAPIC ACID ATTENUATES 7,12 DIMETHYLBENZ[A] ANTHRACENE INDUCED ORAL CARCINOGENESIS BY IMPROVING THE APOPTOTIC ASSOCIATED GENE EXPRESSION IN HAMSTERS
... 7,12-dimethylbenz[a] anthracene (DMBA)-induced experimental carcinogenesis in hamster have shown that [6] paradol facilitate the apoptosis as evidenced by the expression of p53 related gene expression ...
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LUPEOL PROTECTS ABNORMALITIES IN CELL SURFACE MOITIES DURING 7, 12 DIMETHYLBENZ[A]ANTHRACENE INDUCED HAMSTER BUCCAL POUCH CARCINOGENESIS
... Lupeol, a pentacyclic triterpene, possesses diverse pharmacological and biochemical activities including anticancer and antioxidant effects. Abnormalities in the status of glycoconjugates and lipids in the cell results ...
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Anticancer and Anti inflammatory Potentials of Thymoquinone (an Active Ingredient from Nigella sativa seeds) Studied in 7, 12 Dimethylbenz(α)anthracene Induced Experimental Breast Cancer
... Plant derived compounds have been reported for their anticancer as well as antioxidant potential. Thymoquinone, the bioactive principle of Nigella sativa seeds possess a wide array of beneficial as well as ...
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Studies on the Chemopreventive Potential of N-acetyl cysteine/ zinc oxide nanocomposite combined with High ascorbate on 7,12-dimethylbenz(a)anthracene Induced Mammary Carcinogenesis in Rats
... Oral bicarbonate therapy plays an essential role in reducing the metastases in experimental models of breast and prostate cancers. Its effect mainly appears on enhancing the pHe that consequently reduced the release of ...
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Lack of ecotropic virus involvement in induction of lymphomas in DBA/2J mice by 7,12-dimethylbenz(a)anthracene.
... Since DBA/2J mice represent a unique system for the study of chemically induced B-cell lymphomas, it will be interesting to compare the nature of the activating lesions present in DMBA-i[r] ...
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Neonatal exposure of 17β-estradiol has no effects on mutagenicity of 7,12-dimethylbenz [a] anthracene in reproductive tissues of adult mice
... the body’s endocrine system) during early stages of development can disrupt normal patterns of develop- ment and alter disease susceptibility later in life [12]. About three decades ago, a concern was expressed ...
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PROTECTIVE EFFECT OF APIGENIN ON 7, 12 DIMETHYLBENZ (A) ANTHRACENE INDUCED GLYCOCONJUGATES IN THE PLASMA AND BUCCAL MUCOSA OF GOLDEN SYRIAN HAMSTERS
... Present study investigated the protective effect of apigenin on cell surface glycoconjugates abnormalities in 7, 12-dimethyldenz(a)anthracene(DMBA) induced hamster buccal pouch carcinogenesis. DMBA painting ...
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Vitamin D postpones the progression of epithelial ovarian cancer induced by 7, 12-dimethylbenz [a] anthracene both in vitro and in vivo
... vitamin D3 was administered at a dose of 20,000 IU/kg every week for a duration of 20 weeks; 3) a 4-week VD group (initiation), vitamin D3 was treated every week from day 0 until the day prior to DMBA implanted; 4) a ...
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Cissus quadrangularis inhibits tumor formation during 7, 12-dimethylbenz (a) anthracene induced oral carcinogenesis
... Though CqELet inhibited the formation of oral tumors in the buccal pouch of the DMBA treated hamsters, the observed precancerous lesions such as hyperkeratosis, hyperplasia a[r] ...
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P-MAPA immunotherapy potentiates the effect of cisplatin on serous ovarian carcinoma through targeting TLR4 signaling
... Forty adult female Fischer 344 rats (60-day-old, weighing ±200 g), were obtained from the Multidisciplinary Center for Biological Investigation (CEMIB) at University of Campinas (UNICAMP). Animals were individually ...
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Chemopreventive Potential of Bauhinia variegata Flower Extract Against DMBA-induced Skin Papillomagenesis in Mice
... 7, 12-dimethylbenz(a)anthracene (DMBA) (104 µg/ 100 µl acetone), and one weeks later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 ...
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EVALUATION OF THE ANTICARCINOGENIC EFFECT OF SOME PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR LIGANDS ON DIMETHYLBENZ (α) ANTHRACENE INDUCED MAMMARY TUMOR IN FEMALE RATS
... Introduction: Breast cancer is the leading cause of cancer death among females worldwide. Peroxisome proliferator activated receptors (PPARs) are one of several nuclear receptors involved in the biology of breast cancer. ...
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Lack of cortistatin or somatostatin differentially influences DMBA induced mammary gland tumorigenesis in mice in an obesity dependent mode
... 7, 12 dimethylbenz[ α ]anthracene (DMBA), an immunosuppressor and a powerful organ- specific laboratory carcinogen, on mammary gland (MG) hyperplasia and tumor formation/progression in the presence ...
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Modification in polyaniline oxidation state as a consequence of anthracene doping
... with anthracene emulsion polymerization ...to anthracene concentration. The anthracene doping may give rise to mainly two possibilities, 1) Segregation of anthracene molecules as non ...
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