12-Lipoxygenase
Intracellular Zinc Release, 12-Lipoxygenase Activation and MAPK Dependent Neuronal and Oligodendroglial Death
... Zinc translocation from presynaptic nerve terminals to postsynaptic neurons has generally been considered the critical step leading to the accumulation of intracellular free zinc and subsequent neuronal injury. Recent ...
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Resistance to type 1 diabetes induction in 12 lipoxygenase knockout mice
... Leukocyte 12-lipoxygenase (12-LO) gene expression in pancreatic β cells is upregulated by cytotoxic cytokines like ...that 12-LO inhibitors can prevent glutamate- induced neuronal cell death ...
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A maresin 1/RORα/12 lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis
... 0.01 for A and B. (C) DHA-treated peritoneal macrophages (PM) and Raw 264.7 cells were treated with 5 μM SR1078 for 24 hours, or the cells were infected by lenti-shGFP or lenti-shRORα for 48 hours. Intracellular amount ...
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Lipoxin formation during human neutrophil platelet interactions Evidence for the transformation of leukotriene A4 by platelet 12 lipoxygenase in vitro
... for lipoxygenase (LO)-derived products has been implicated in each of these events; therefore, we investigated the formation of lipoxins during coincubation of human neutrophils and ...displayed 12-LO ...
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Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m
... Computational selection of the best curcumin derivative Selectivity plays a major role in drug targeting process. It can help in identifying the most suitable ligand (key) for a specific enzyme (lock). Computational ...
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<p>12-Lipoxygenase promotes epithelial–mesenchymal transition via the Wnt/β-catenin signaling pathway in gastric cancer cells</p>
... of 12-LOX on tumorigenesis and metastasis were investigated in vivo using a mouse xenograft ...expressing 12-LOX were inoculated into nude mice in the OE group via the tail vein, and the normal BGC823 cells ...
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Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase
... Recently, it has been reported, using an anesthetized rabbit model of cough that BK, microinjected into the nTS, enhanced the cough reflex but did not affect respiratory parameters [ 24 [r] ...
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Mechanisms controlling cell cycle arrest and induction of apoptosis after 12 lipoxygenase inhibition in prostate cancer cells
... shown 12-LOX to be expressed in the prostate cancer cell lines DU-145 and PC3 (15); however, its exact role in these cells is not fully ...of 12-LOX inhibition on prostate cancer cells and more impor- ...
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Complement independent Ab induced peroxide lysis of platelets requires 12 lipoxygenase and a platelet NADPH oxidase pathway
... Suggestive evidence for the presence of an NADPH oxidase in platelets has been reported by us (10), as well as others (38, 39). None of these reports present rigorous evidence for a function- ing granulocyte-like NADPH ...
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Systems pharmacology based approach to investigate the in vivo therapeutic efficacy of Albizia lebbeck (L ) in experimental model of Parkinson’s disease
... Arachidonate 12- lipoxygenase, 12S-type; ALOX12B: Arachidonate 12-lipoxygenase, 12R-type; ALOX15: Arachidonate 15-lipoxygenase; ALOX15B: Arachidonate 15- lipoxygenase B; ALOX5: ...
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GLI2 promoter hypermethylation in saliva of children with a respiratory allergy
... Arachidonate 12-lipoxygenase; APOBEC1: Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; CCR: Chemokine receptors; CD: Cluster of differentiation; DMRs: Differentially methylated gene regions; ...
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Fatty Acid Metabolism Mediated by 12/15-Lipoxygenase is a Novel Regulator of Hematopoietic Stem Cell Function and Myelopoiesis
... that 12/15-LOX promotes HSC self- renewal and quiescence, which is associated with the activation of canonical Wnt ...that 12/15-LOX-mediated redox signaling of SHP-2 and the transcription factor ICSBP/ ...
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Expression of 5 lipoxygenase and 15 lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
... 15-Lipoxygenase (15-LO) is a lipid-peroxidizing enzyme mainly expressed in airway epithelial cells, eosinophils, reticulocytes and macrophages. In humans, 15-LO exists as two different enzymes with different cell ...
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Enhancement of Porcine Alveolar Macrophage Response to Respiratory Pathogens by Dietary Supplementation of Long-chain PUFA.
... 12 load in the lungs (5.19 ± 0.15 and 4.4 ± 0.16 cfu, respectively) compared to the n-3 treatment group (5.73 ±0.11 and 5.7 ± 0.25 cfu, respectively). T-cell function and proliferative abilities in the spleen were ...
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Disruption of the 12/15 lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
... L-12LO gene was apparently sufficient to yield similar lesion size in mice expressing 2 copies of the L-12LO gene on an apo E–deficient background, indicating no gene dosage effects. These lesion data are even more ...
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In vitro Evaluation of Antiproliferative, Lipoxygenase and Xanthine Oxidase Inhibitory Activities of Artemisia nilagirica (C.B.Clarke) Pamp. Leaf Extracts
... In vitro Evaluation of Antiproliferative, Lipoxygenase and Xanthine Oxidase Inhibitory Activities of Artemisia nilagirica (C.B.Clarke) Pamp.. GHAZI*.[r] ...
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Journal of Applied Pharmaceutical Science
... Lipoxygenase and Xanthine Oxidase are key enzymes implicated in many mediated inflammation diseases such as cancers, arthrosclerosis, hypertension and diabetes (Osher et al., 2006). Their inhibition could be a way ...
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Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques
... 15- lipoxygenase on polyunsaturated fatty acids (PUFAs) in vivo, we have used a sensitive and specific method (chiral phase HPLC) to analyze the lipid oxidation products present in human atherosclerotic ...omega-6 ...
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In-Vitro Anti-inflammatory Activity Evaluation of the Latex Protease of Holostemma Ada-Kodien Schult
... The anti-inflammatory effects of H. ada-kodien latex protease (HA protease) on the production of leukotrienes were estimated by inhibition of lipoxygenase activity. Results are shown in the Table.2. The HA ...
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The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5 lipoxygenase activating protein
... compartment in the initiation and progression of OA [6-8]. We already identified that a growth factor, hepatocyte growth fac- tor, is produced more abundantly by OA osteoblasts than by normal osteoblasts, yet hepatocyte ...
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