12(R)-HETE
12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer
... µM 12-HETE antagonized the decrease in cell viability induced by SD, but the effects of 12-HETE on cell survival were abolished after repressing the expression of ILK with siILK (Figure ...µM ...
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12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12- HETE and 13-HODE in animal models
... including 12- or 15-hydroxyeicosatetraenoic acid (12-HETE, 15-HETE) or leukotriene B4 levels were comparable between normal colon and colorectal ...
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Studies on the mechanism of omega hydroxylation of platelet 12 hydroxyeicosatetraenoic acid (12 HETE) by unstimulated neutrophils
... of 12-hydroxyeicosatetraenoic acid (12-HETE), which is chemotactic and chemokinetic, and enhances mononuclear cell procoagulant ...platelet 12-HETE is metabolized ...
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Eicosanoid excretion in hepatic cirrhosis Predominance of 20 HETE
... The cytochrome P450 system transforms AA to hydroxy- eicosatetraenoic acid (HETE) metabolites that are vasoac- tive and affect transport in several nephron segments. A principal product of this system, ...
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20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice
... hour for 4 h to minimize trauma and reduce airway tone as well as removing any remaining agarose in the tissue. Media was also changed first thing the following day. Up to four slices from each animal were placed in a ...
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Mesangial cell immune injury Synthesis, origin, and role of eicosanoids
... and 12-hydroxyeicosatetraenoic acid (HETE), whereas that of PGE2 and PGF2 alpha was either unaltered or ...and 12-HETE and the decrements in GFR and ...
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12/15 Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy
... type 12/15-lipoxygenase inhibition or gene defi- ciency alleviated large and small nerve fiber dysfunction, but not intraepidermal nerve fiber loss in streptozotocin-diabetic ...pharmacological ...
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Ischemia reperfusion injury promotes recurrence of hepatocellular carcinoma in fatty liver via ALOX12-12HETE-GPR31 signaling axis
... product 12-HETE, were acti- vated during the early stages of hepatic IRI ...ALOX12–12- HETE was further enhanced in NAFLD during IRI than the normal livers, and the inhibition of ALOX12 by ...
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Differential gene expression mediated by 15 hydroxyeicosatetraenoic acid in LPS stimulated RAW 264 7 cells
... structural HETE isomer that is associated with Hz; 5-, 8-, 9-, 11-, and 12-HETE have also been iden- tified ...yet 12-HETE may exert greater biological activity ...
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Effects of Arachidonic Acid, Monohydroxyeicosatetraenoic Acid and Prostaglandins on the Release of Mucous Glycoproteins from Human Airways In Vitro
... synthetic HETE (24-600 nM) increases mucous release; (b) pure 12-HETE (1-100 nM) also increases mucous release; (c) mucous release is increased synergistically by the combination of HETE and ...
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Glomerular arachidonate lipoxygenation in rat nephrotoxic serum nephritis
... of 12-HETE production. Increments of glomerular 12-HETE persisted on day 7 and returned toward control levels by day ...glomerular 12- HETE synthesis in NSN, thereby eliminating ...
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Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease
... and 12-HETE plasma levels in Cy/+ ...of 12/15-LOX activity should be an attractive target to reduce angiotensin II-mediated oxidative stress, vascular inflamma- tion, cell proliferation and ...
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Hydroxyeicosatetraenoic acid metabolism in cultured human skin fibroblasts Evidence for peroxisomal beta oxidation
... oxidation, 12- and 15-HETE oxidation was measured in normal and peroxisomal deficient skin fibroblasts from patients with Zellweger's (cerebrohepatorenal) ...the 12-HETE radioactivity was ...
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Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12 L hydroxy 5,8,10,14 eicosatetraenoic acid
... partially-purified HETE at peak chemotactic concentrations of 8-24 mug/ml reduced their random and chemotactic migration and stimulated the activity of their hexose monophosphate shunt; minimally chemotactic ...
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Synthesis of hydroxyeicosatetraenoic acids and leukotrienes in rat nephrotoxic serum glomerulonephritis Role of anti glomerular basement membrane antibody dose, complement, and neutrophiles
... glomerular basement membrane (GBM) immunoglobulin (Ig). In the early heterologous phase of the disease, low doses of anti-GBM Ig enhanced the basal synthesis of 12-HETE but not that of 5-HETE or LT. ...
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12. Riesz projection and Weyl's theorem for hereditary absolute-$(p,r)$-paranormal operators
... operators has been proved by Stampfli [20] and this result was extended for w- hyponormal by Han, Lee and Wang [12], for class A and paranormal operators by Uchiyama ([23], [24]). Duggal [9] investigated the ...
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Experimental Analysis of Vapour Compression Refrigeration System with Superheating by using R 134a, R 12, R 717 Refrigerant
... and 12% of total losses are caused by ac ...uses r- 407a, r-600a, r-134a are considered and analysis with respect to exergy ...refrigerant r-134a give better performance with respect to ...
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20 Hydroxyeicosa tetraenoic acid (20 HETE) activates protein kinase C Role in regulation of rat renal Na+,K+ ATPase
... 20 HETE inhibition of rat Na+,K+-ATPase in renal tubular cells. 20 HETE caused translocation of PKC alpha from cytoplasm to membrane in COS ...20 HETE at the physiologic calcium concentration of ...
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12. M.Subramanian, S. Karthik, S. Ravikumar and R. Dhamodaran
... Floristic analysis of Palrampattu has been defined as the theoretical study of classification including its basis, principal, procedures and rules. The results of the pooled data of semi-evergreen vegetation type ...
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Original Article The correlation between calcification in carotid plaque and stroke: calcification may be a risk factor for stroke
... We investigated the association between calcification in carotid plaque and stroke by analyzing the different characteristics of calcification and neovascularization distribution in hete[r] ...
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