12(S)-Lipoxygenase
12/15 Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy
... type 12/15-lipoxygenase inhibition or gene defi- ciency alleviated large and small nerve fiber dysfunction, but not intraepidermal nerve fiber loss in streptozotocin-diabetic ...pharmacological ...
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12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12- HETE and 13-HODE in animal models
... human 12-LOX metabolizes AA to pro-tumor ...of 12- LOX and 15-LOX-1 and 15-LOX-2 is carried out by a single enzyme, ...of 12-LOX and 15-LOX have been obtained in animal ...in 12-HETE ...
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Disruption of the 12/15 lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
... of 12/15-lipoxygenase in atherogenesis and demonstrate diminished plasma IgG autoantibodies to oxidized LDL epitopes in 12/15-lipoxygenase knockout mice crossbred with atherosclerosis-prone ...
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Intracellular Zinc Release, 12-Lipoxygenase Activation and MAPK Dependent Neuronal and Oligodendroglial Death
... Zinc translocation from presynaptic nerve terminals to postsynaptic neurons has generally been considered the critical step leading to the accumulation of intracellular free zinc and subsequent neuronal injury. Recent ...
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12/15 lipoxygenase–mediated enzymatic lipid oxidation regulates DC maturation and function
... that 12/15-lipoxygenase–meditated (12/15-LO–mediated) enzymatic lipid oxidation regulates DC activation and fine-tunes consecutive T cell ...Specifically, 12/15-LO activity determined the DC ...
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Resistance to type 1 diabetes induction in 12 lipoxygenase knockout mice
... and lipoxygenase metabolites in nutrient- and glucose-stimulated insulin secretion in ...by lipoxygenase enzymes, as it was not prevented by lipoxy- genase inhibitors ...and/or 12-HETE into membrane ...
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Brem, Christian (2018): Effekte der Lipoxygenase-12/15- und der Lipoxygenase-5-Hemmung auf die Entwicklung des sekundären Hirnschadens nach experimentellem Schädel-Hirn-Trauma. Dissertation, LMU München: Medizinische Fakultät
... dass 12-HETE Calciumkanäle regulieren kann 294 und zwingend erforderlich ist für den Ca 2+ - Einstrom in die Zelle 295 ...durch 12-HETE geregelt 297 ...der Lipoxygenase-12/15 deutlich ...
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A maresin 1/RORα/12 lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis
... and 12/15-LOX (catalog ab80221) (both from Abcam); NLRP3 (catalog 15101) and caspase 3 (catalog 9665)(both from Cell Signaling), or 12-LOX (catalog NBP2- 29941; Novus Biologicals) ...(catalog ...
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Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m
... © The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, ...
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Complement independent Ab induced peroxide lysis of platelets requires 12 lipoxygenase and a platelet NADPH oxidase pathway
... platelet 12-LO path- way being upstream of the NADPH oxidase ...the 12-LO product, 12(S)-HETE, induces platelet fragmentation even in platelets from 12-LO–defi- cient ...of ...
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Mechanisms controlling cell cycle arrest and induction of apoptosis after 12 lipoxygenase inhibition in prostate cancer cells
... implicate 12-LOX as a regulator of human cancer ...platelet-type 12-LOX and 12(S)- HETE in prostate ...that 12-LOX is expressed in several prostate cancer cell lines ...the ...
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Fatty Acid Metabolism Mediated by 12/15-Lipoxygenase is a Novel Regulator of Hematopoietic Stem Cell Function and Myelopoiesis
... We tested whether 12/15-LOX regulates self-renewal capacity using two approaches. In the first, we compared the self-renewal capacity of Alox15 and B6 HSCs in serial transfer assays in the absence of competitors. ...
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Systems pharmacology based approach to investigate the in vivo therapeutic efficacy of Albizia lebbeck (L ) in experimental model of Parkinson’s disease
... Arachidonate 12- lipoxygenase, 12S-type; ALOX12B: Arachidonate 12-lipoxygenase, 12R-type; ALOX15: Arachidonate 15-lipoxygenase; ALOX15B: Arachidonate 15- lipoxygenase B; ALOX5: ...
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GLI2 promoter hypermethylation in saliva of children with a respiratory allergy
... Arachidonate 12-lipoxygenase; APOBEC1: Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; CCR: Chemokine receptors; CD: Cluster of differentiation; DMRs: Differentially methylated gene regions; ...
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Chap 12 Light 12 S
... – The internal reflection is the situation where all the light rays is reflected within the medium, when it moves from a optically denser to a less dense medium with the angle of inci[r] ...
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Chap 12 Lens 12 S
... In order to obtain a sharp image on the screen, a lens with a suitable focal length must be used. Using a ray diagram, find the suitable focal length of the lens[r] ...
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Arachidonic Acid Metabolism in the Neonatal Platelet
... Evaluation of the products of the lipoxygenase and cyclooxygenase pathway in the platelet of the neonate revealed an increase in the production of the lipoxygenase product HETE, whereas [r] ...
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An evaluation of the Sherwood S-12 system for use with the SMA 12/60
... TABLE OF CONTENTS Page Vitae ii Acknowledgements Hi Table iv Contents of List of Tables vi List of Figures vii Introduction 1 Experimental 4 Technicon SMA 12/60 Sherwood S- 4 12 System 5[r] ...
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Chap 21 Electromagnetism 12 S
... carrying conductor in a magnetic field Fleming’s Left hand rule Electromagnetism Electric motor Electric motor. is shown by[r] ...
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Chap 11 ThermalProperties 12 S
... that is needed to change unit mass of the substance from liquid state to vapour state, without a change in temperature. SI: J/kg[r] ...
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