15-Lipoxygenase
Expression of 5 lipoxygenase and 15 lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
... humans, 15-LO exists as two different enzymes with different cell localizations and product profiles ...[10]. 15-LO-1 converts AA to an unstable intermediate, 15- hydroperoxyeicosatetraenoic acid, ...
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Arachidonate 15 lipoxygenase is required for chronic myeloid leukemia stem cell survival
... arachidonate 15-lipoxygenase (Alox15/15-LO) is essential for the survival of leukemia stem cells (LSCs) in a murine model of BCR-ABL–induced chronic myeloid leukemia ...of 15-LO function ...
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Disruption of the 12/15 lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
... 12/15- lipoxygenase, oxidation of LDL, and atherosclerosis lesion development? The 12/15-lipoxygenases are cytosolic intracellular enzymes that can interact with plasma membrane or intracellular ...
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12/15 Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy
... Sciatic nerve and spinal cord materials (~3 - 10 mg) or scraped human Schwann cells were placed on ice in 100 µL of buffer containing 50 mmol/l Tris-HCl, pH 7.2; 150 mmol/l NaCl; 0.1% sodium dodecyl sulfate; 1% NP-40; 5 ...
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12/15 lipoxygenase–mediated enzymatic lipid oxidation regulates DC maturation and function
... DCs are able to undergo rapid maturation, which subsequently allows them to initiate and orchestrate T cell–driven immune responses. DC maturation must be tightly controlled in order to avoid random T cell activation and ...
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12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12- HETE and 13-HODE in animal models
... Human 15-lipoxygenase 1 (15-LOX-1) converts LA to anti-tumor 13-S-hydroxyoctadecadienoic acid (13-HODE) and 15-LOX-2 converts AA to 15-hydroxyeicosatetraenoic acid ...and ...
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Immunocytochemical localization of arachidonate 15 lipoxygenase in erythrocytes, leukocytes, and airway cells
... enzyme 15-lipoxygenase (15-LO) is believed to contribute to cellular differentiation, and in leukocytes and airway cells 15-LO generates inflammatory ...to 15-LO now allows us to ...
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In vivo action of 15 lipoxygenase in early stages of human atherogenesis
... the 15- lipoxygenase may isomerize if they are not rapidly ...upon 15-lipoxygenase nonenzymatic propagation reactions would quickly wipe out any major excess of the S-iso- mer, even if the ...
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Gene expression in macrophage rich human atherosclerotic lesions 15 lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid protein adducts
... that 15-lipoxygenase mRNA and protein colocalize to the same macrophage-rich ...by 15-lipoxygenase, leading to subsequent enhanced macrophage uptake, partly by way of the acetyl LDL ...
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Transfer of 15 lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation specific lipid protein adducts characteristic of oxidized low density lipoprotein
... the 15-lipoxygenase activity are involved in the induction of LDL oxidation within the arterial wall, provided that sufficient concentrations of lipoproteins are present in the ...
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Macrophage mediated 15 lipoxygenase expression protects against atherosclerosis development
... and 15-lipoxygenase (15-LO) has been implicated in the ...expressed 15-LO in a macrophage-specific manner and studied their susceptibility to atherosclerosis develop- ment when they were fed a ...
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Fatty Acid Metabolism Mediated by 12/15-Lipoxygenase is a Novel Regulator of Hematopoietic Stem Cell Function and Myelopoiesis
... We demonstrated that basal levels of ROS are increased in Alox15 LSK. The increased basal levels of ROS in Alox15 LSK could be a result of decreased representation of LT-HSC, which express low levels of ROS compared to ...
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The Role of 15-Lipoxygenase-1- and Cyclooxygenase-2-Derived Lipid Mediators in Endothelial Cell Proliferation
... of 15-oxo-ETE on ECs, thus potentially exacerbating colorectal ...of 15-oxo-ETE to inhibit EC proliferation suggests that it might be involved in other conditions where macrophage and/or endothelial cell ...
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Human alveolar macrophages have 15 lipoxygenase and generate 15(S) hydroxy 5,8,11 cis 13 trans eicosatetraenoic acid and lipoxins
... of 15-LO mRNA and enzyme activity in HAM and the production of LXA4 and LXB4 by these ...of 15-LO-derived eicosanoids by HAM may also be relevant in modulating inflammatory responses in the ...
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Human articular chondrocytes express 15 lipoxygenase 1 and 2: potential role in osteoarthritis
... 4% paraformaldehyde and embedded in paraffin. Sections (5 μm) of paraffin-embedded specimens were deparaffinized in toluene, and dehydrated in a graded series of ethanol. The specimens were then pre-incubated with ...
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Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas
... for 15- HETE [32]. Based on our data, the higher level of 15- Lox-2 and its metabolite 15-HETE was observed in hormone-secreting pituitary tumors comparing to NFPAs which might support the previous ...
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Antioxidant and Lipoxygenase Inhibitory Activity of the Kino of Eucalyptus citriodora
... and 15-lipoxygenase inhibitory activity of ethanol extract and its ethyl acetate, n-butanol and aqueous fractions of Eucalyptus citriodora kino were ...the 15-lipoxugenase assay, ...against ...
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Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques
... enzyme 15-lipoxygenase as a contributor to the formation of oxidized lipids in this ...of 15- lipoxygenase on polyunsaturated fatty acids (PUFAs) in vivo, we have used a sensitive and specific ...
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Brem, Christian (2018): Effekte der Lipoxygenase-12/15- und der Lipoxygenase-5-Hemmung auf die Entwicklung des sekundären Hirnschadens nach experimentellem Schädel-Hirn-Trauma. Dissertation, LMU München: Medizinische Fakultät
... der Lipoxygenase-12/15 vor Trauma das Gesamtvolumen des Hirnschadens nach Schädelhirntrauma ...der Lipoxygenase-12/15-Spiegel im Gehirn nachweisen und eine Prognose- und Outcomeverbesserung ...
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Oxidative stress mitigation and the inhibition of carbohydrate-hydrolysing, lipoxygenase (15-LOX), and acetylcholinesterase enzymes by methanolic crude extracts and partitioned fractions of Rinorea dentata (P Beauv.) O Ktze. leaf and stem
... inflammation with acetylcholine playing a role in the release of cytokine (Borovikova et al., 2000). Lipid-peroxidizing enzymes (lipoxygenase) required in the bioformation (from arachidonic acid) of leukotriene ...
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