2-CHLORO-1-(3-ETHYL-2
Crystal structure of 2 chloro 1 (3 ethyl 2,6 diphenylpiperidin 1 yl)ethanone
... A mixture of t-3-methyl-r-2,c-6-diphenylpiperidine (5 mmol), chloroacetyl chloride (20 mmol) and triethylamine (20 mmol) in anhydrous benzene (20 ml) was stirred at room temperature. The precipitated ...
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Ethyl trans 3 (2 chloro 6,7 dimethylquinolin 3 yl) 1 cyclohexylaziridine 2 carboxylate
... derivatives, 2-aminoquinolines, 2-alkoxyquinolines or quinolin-2-(1H)-ones, occupy a promi- nent position in organic synthesis as key intermediates for further annelation and various functional group ...
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Crystal structure of ethyl 2 chloro 6 methylquinoline 3 carboxylate
... The molecular geometry and the atom-numbering scheme of (I) are shown in Fig. 1. In the asymmetric unit of title compound the quinoline ring is three times substituted by two methyl, one chlore and one ...
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Ethyl 2 (2 chloro 1,4 dihydro 1,4 dioxonaphthalen 3 ylamino) 4 phenylthiazole 5 carboxylate
... Molecules of (I) form a one-dimensional hydrogen-bonded chain via a single N—H O interaction [graph set C(6); Etter, 1990], which runs parallel to the b axis; hydrogen-bonding geometry is given in Table 1. A close ...
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Crystal structure of ethyl 2 chloro 5,8 dimethoxyquinoline 3 carboxylate
... of 2-chloro-5,8-dimethoxy quinolin-3- carbaldehyde (1 mmol) and manganese dioxide ...and 3 cm of silica gel using CH 2 Cl 2 as eluant (Valdez, et ...
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Ethyl 4 chloro 2 [(4 nitrophenyl)hydrazono] 3 oxobutyrate
... The packing is further stabilized by C—H and – interactions. There is a C—H interaction between the ethyl group and the aromatic ring. For the C12–H12B contact, the distance between atom H12B and the aromatic ring ...
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Synthesis and structure of 1 (2 bromophenyl) 2 chloro 3 (2 chloracetyl) 1H indole
... with ethyl acetate and petroleum ether (v/v = 1:100) as eluent to obtain a mixture, which consists of the compound of trimer- ization (will be reported elsewhere) and the title compound ...overnight. ...
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Ethyl 2 {1,3 bis[(6 chloro 3 pyridyl)methyl]imidazolidin 2 ylidene} 2 cyanoacetate ethanol solvate
... C5 0.1106 (18) 0.0455 (11) 0.0439 (11) 0.0086 (11) 0.0369 (11) −0.0032 (8) C6 0.0617 (11) 0.0422 (9) 0.0437 (9) 0.0047 (8) 0.0280 (8) 0.0001 (7) C7 0.0484 (11) 0.0752 (13) 0.0612 (12) −0.0016 (9) 0.0293 (9) 0.0033 (10) ...
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5 Chloro 3 ethylsulfinyl 2 (3 fluorophenyl) 1 benzofuran
... Data collection: APEX2 (Bruker, 2009); cell refinement: SAINT (Bruker, 2009); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 ...
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(Z) Ethyl 4 chloro 3 oxo 2 (2 o tolylhydrazono)butanoate
... oate, (III) (Alpaslan et al., 2005b). In (I), the imino group adopts a (Z) configuration. The bond lengths (Table 1) show that there is significant elongation of the N1—N2 bond and contraction of the C1—N1 bond in ...
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Trace Level Quantification of Genotoxic Impurity “3 Chloro N (2 ((2 Dimethylamino) Ethyl) (Methyl) Amino) 4 Methoxy 5 ((4 (1 Methyl 1h Indol 3 Yl) Pyrimidin 2 Yl) Amino) Phenyl) Propanamide” in Osimertinib Mesylate by UPLC QDa
... amino ethyl-methyl amino}-4- methoxy-5-{[4-(1-methylindol-3-yl) pyrimidin-2-yl] amino} phenyl) prop-2-enamide mesylate salt (Figure ...impurity ...
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3 (2 Chloro 4 hydroxyphenyl) 1 thioisocoumarin
... The title compound was synthesized according to the procedure reported earlier (Saeed, 2004). A mixture of 3-(2-chloro-4-hydroxy- phenyl)isocoumarin (5.0 mmol), Lawesson’s reagent (3.0 mmol) and ...
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Crystal structures of ethyl (2S*,2′R*) 1′ methyl 2′′,3 dioxo 2,3 dihydrodispiro[1 benzothiophene 2,3′ pyrrolidine 2′,3′′ indoline] 4′ carboxylate and ethyl (2S*,2′R*) 5′′ chloro 1′ methyl 2′′,3 dioxo 2,3 dihydrodispiro[1 benzothiophene 2,3′ pyrrolidine 2′,3′′ indoline] 4′ carboxylate
... Molecules (I) and (II) differ only in the presence of a chloride atom at position 5 in the oxoindole unit in (II). The conformation of the two molecules differ in the angle of inclination of the indole moiety with ...
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2 Chloro N (2 chlorobenzoyl) N (2 ethyl 4 oxo 3,4 dihydroquinazolin 3 yl)benzamide
... almost perpendicular with a dihedral angle of 89.1 (1)°. However, the imide moiety itself is not strictly planar. The dihedral angle between the two components (O1A C1A N and O1B C1B N) is 34.6 (1)°. The ...
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(Z) Ethyl 2 chloro 2 [2 (4 methylphenyl)hydrazinylidene]acetate
... The title compound, Fig. 1, and II contain methyl and methoxy groups respectively at para positions of aromatic ring, which make them different from each other. The aromatic ring (C1—C6) is oriented at a dihedral ...
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(Z) Ethyl 4 chloro 2 [(4 chlorophenyl)hydrazono] 3 oxobutanoate
... The crystal was non-merohedral twin with a twinning ratio of 0.51:0.49 and the reflection data were measured for the two twin domains, scaled and combined together, but overlapping reflections could not be satisfactorily ...
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Ethyl 4 chloro 2 [(2 nitrophenyl)hydrazono] 3 oxobutyrate
... 2003). 3-Phenylhydrazono-2,4-diones and their derivatives are used for the treatment of cancer or AIDS, or of opportunistic infections afflicting patients with cancer or AIDS (Monga & Sausville, ...
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(Z) Ethyl 4 chloro 2 [2 (2 methoxyphenyl)hydrazono] 3 oxobutanoate
... group adopts a Z configuration, with bond lengths C1—N1 = 1.408 (2) A ˚ , C8—N2 = 1.311 (2) A˚ and N1—N2 = 1.300 (2) A˚. These data show that there is significant elongation of the N1—N2 bond and ...
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Methyl 3 (2 chloro 5 ethyl 3 pyridyl) 3 hydroxy 2 methylenepropanoate
... of 2-chloro-5-ethyl- pyridine-3-carbaldehyde (5 mmol) and methyl acrylate (5 mmol) in methanol (5 ml), the reaction mixture being stirred at room temperature in the presence of ...
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(2E) 3 (2 Chloro 7 methylquinolin 3 yl) 1 (6 chloro 2 methyl 4 phenylquinolin 3 yl)prop 2 en 1 one ethanol monosolvate
... of 3-acetyl-6-chloro-2-methyl-4-phenylquinoline (300 mg, ...and 2-chloro-7-methylquinoline-3- carbaldehyde (200 mg, ...an ethyl acetate-hexane (4:1) mixture to ...
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