2'-DEOXYGUANOSINE
2' deoxyguanosine toxicity for B and mature T lymphoid cell lines is mediated by guanine ribonucleotide accumulation
... substrate, 2'- ...that 2'-deoxyguanosine toxicity for T lymphoblasts is markedly potentiated by 8-aminoguanosine and is mediated by the accumulation of deoxyguanosine ...of ...
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Immunohistochemical expression of 8 oxo 7,8 dihydro 2′ deoxyguanosine in cytoplasm of tumour and adjacent normal mucosa cells in patients with colorectal cancer
... Colorectal cancer (CRC) originates from the colonic mucosal epithelial cells and represents a genomic dis- ease that is the result of the cumulative effect of exter- nal and hereditary factors. Progression of the tumour ...
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Mitochondrial 8-hydroxy-2′-deoxyguanosine and coronary artery disease in patients with type 2 diabetes mellitus
... Mitochondrial DNA (mtDNA) is more vulnerable to the accumulation of ROS-mediated damage than nuclear DNA, in part because of its close proxim- ity to the mitochondrial oxidative phosphorylation chain, and because it ...
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Iron Indices and Urinary 8-Oxo-7, 8-Dihydro-2’- Deoxyguanosine (8-Oxodg) in Patients with Cervical Intraepithelial Neoplasia
... It is proposed in this study that iron overload may exist in women with attendant disorders of iron homeostasis and consequent increase in free iron. Iron overload could also occur by non- selective administration of ...
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XANTHINE OXYDASE INHIBITION OF KOMBUCHA TEA IN HYPERURICEMIA INDUCED WISTAR RAT: decrease of uric acid, malondialdehyde, and 8-hydroxy-2'-deoxyguanosine
... Background: Hyperuricemia is a condition of high level of uric acid in the body due to distortion of purine nucleoside metabolism through hipoxanthin, xanthin, and guanin of basic purine. Objective: to find a cure of ...
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Synthesis of Tricyclic Nucleoside Analogue of <i>O</i>6-Methyl-2'-Deoxyguanosine - Volume 4 Number 2 (Apr. 2013) - IJCEA
... The bis-chlorination was carried out on compound 10 by refluxing with phosphoryl chloride at 80˚C for two hours. The product was purified by silica column chromatography to give a white solid 11 in 20% yield. Compound 9 ...
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The carbocyclic analog of 2'-deoxyguanosine induces a prolonged inhibition of duck hepatitis B virus DNA synthesis in primary hepatocyte cultures and in the liver.
... In another respect, however, 2'-CDG exhibited antiviral activity unlike that of ddC or PFA: a single 1-day treatment of hepatocytes with 2'-CDG blocked initiation of viral DNA synthesis [r] ...
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Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions
... A limited number of epidemiological studies reported that 8-OHdG was associated with exposures to indoor and ambient pollution or smoking, but they were con- ducted among a small number of children or occupa- tionally ...
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Treatment with L citrulline in patients with post polio syndrome: study protocol for a single center, randomised, placebo controlled, double blind trial
... Adverse events are monitored throughout the study. At every study visit, patients are asked about adverse events. At visits 1, 3, 4 and 5, a physical examination will be performed and the vital parameters will be ...
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<p>Lipoic Acid Decreases the Expression of Poly ADP-Ribose Polymerase and Inhibits Apoptosis in Diabetic Rats</p>
... Eight-week-old, male Sprague – Dawley rats (n=40; body weight, 210 – 240 g) (Beijing Weitonglihua Experimental Animal Technology Co. Ltd., Beijing, China); streptozotocin (STZ) and LA (Sigma company, Saint Louis, USA); ...
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High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors
... Patients and methods: Two hundred forty-one first-ever ischemic stroke patients were consecutively recruited within the first 24 h of stroke onset and were followed up at 1 month. Serum ...
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Oxidative stress-related biomarkers in Parkinson’s disease: A systematic review and meta-analysis
... 8-Oxo-2'- deoxyguanosine (8-oxo-dG), and lipid hydro- peroxide (LPO) were found to be high in patients with PD as compared to controls with P < ...
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Deoxyadenosine triphosphate as a mediator of deoxyguanosine toxicity in cultured T lymphoblasts
... which 2'-deoxyguanosine is toxic for lymphoid cells is relevant both to the severe cellular immune defect of inherited purine nucleoside phosphorylase (PNP) deficiency and to attempts to exploit PNP ...
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Original Article Asiatic acid attenuates traumatic brain injury via upregulating Nrf2 and HO-1 expression
... Abstract: The neuroprotective role of asiatic acid (AA) against cerebral ischemia has been previously reported. However, whether AA attenuates traumatic brain injury (TBI) has not been investigated. The current study ...
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Oxidative stress and DNA damage in patients with migraine
... TOS: total oxidant status; TAS: total antioxidant status; OSI: oxidative stress index; 8-OHdG: 8-hydroxy-2 ′ -deoxyguanosine; ICHD-3 beta: International Classification of Headache Disorders 3rd edition-beta ...
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Intake of medium-chain fatty acids induces myocardial oxidative stress and atrophy
... and immunohistochemical staining to observe tissue morphology, oxidative stress accumulation, and mito- chondrial volume in the myocardial tissues. We used an anti-8-hydroxy-2′-deoxyguanosine (8-OHdG) ...
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Urinary cell-free mitochondrial and nuclear deoxyribonucleic acid correlates with the prognosis of chronic kidney diseases
... 8-OH dG: 8-hydroxy-2-deoxyguanosine; ACR: albumin-creatinine ratio; AKI: acute kidney injury; cf-DNA: cell-free DNA; cf-mtDNA: cell-free mitochondrial DNA; cf-nDNA: cell-free nuclear DNA[r] ...
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Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs
... Among the different types of ROS-induced DNA damage, the oxidation of guanine and consequently the formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG) is the most common one [7]. Oxidative DNA damage can be ...
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Evaluating Markers of Oxidative Stress in Managing Gestational Diabetes Mellitus: A Cross Sectional Study in Iraq
... Oxidative stress occurs when there is an imbalance between generation of free radicals (reactive oxygen and nitrogen species) and the antioxidants scavenging ability [4]. Both of which are disturbed in hyperglycaemia ...
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NBAS mutations cause acute liver failure: when acetaminophen is not a culprit
... for deoxyguanosine kinase (DGUOK), DNA polymerase γ (POLG) mutations and other genes com- monly involved in mitochondrial DNA depletion [8–11], showed no pathogenic mutations [7, 12, ...
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