2-methoxyestradiol
2-Methoxyestradiol-bis-sulphamate refrains from inducing apoptosis and autophagy in a non-tumorigenic breast cell line
... Researchers have identified a promising anticancer compound, 2-methoxyestradiol (2ME), that exerts antimitotic- and antiproliferative activity in vitro and in vivo [1,2]. However, 2ME failed to advance to ...
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Effect of magnetic Fe3O4 nanoparticles with 2-methoxyestradiol on the cell-cycle progression and apoptosis of myelodysplastic syndrome cells
... of 2- methoxyestradiol (2ME) and magnetic nanoparticles of Fe 3 O 4 (MNPs-Fe 3 O 4 ) on myelo- dysplastic syndrome (MDS) SKM-1 cells and its underlying ...G 2 /M phase than in 2ME alone, which may be ...
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A novel non-sulphamoylated 2-methoxyestradiol derivative causes detachment of breast cancer cells by rapid disassembly of focal adhesions
... derivative, 2-ethyl-estra-1,3,5 (10),15-tetraen-3-ol-17-one, or EE-15-one, affected can- cer cell survival with a half maximal effective concentra- tion (EC 50 ) in the low micromolar range ...
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Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer
... (SH30604.02); 2-methoxyestradiol from Sigma-Aldrich (M6383); SB203580 p38-MAPK inhibitor from Cayman chemical (13067); DHA (3687) from Tocris Biosciences; 100x HALT protease and phosphatase inhibitor ...
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Efficacy of Intravitreal injection of 2-Methoxyestradiol in regression of neovascularization of a retinopathy of prematurity rat model
... of 2-Methoxyestradiol (2-ME) nanoemulsion in regressing neovascularization of a ROP rat ...of 2-ME nanoparticles were injected in right eyes of 14 rats (low dose; study group I, high dose; ...
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Influence of 2-methoxyestradiol and sex on hypoxia-induced pulmonary hypertension and hypoxia-inducible factor-1-α
... indicates 2-methoxyestradiol; ERa, estrogen receptor-alpha; ERb, estrogen receptor-beta; hPASMCs, human pulmonary arterial smooth muscle cells; Veh, ...
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Photodynamic therapy of a 2-methoxyestradiol tumor-targeting drug delivery system mediated by Asn-Gly-Arg in breast cancer
... Abstract: Fullerene (C60) has shown great potential in drug delivery. In this study we exploited modified fullerene (diadduct malonic acid-fullerene-Asn-Gly-Arg peptide [DMA-C60-NGR]) as an antitumor drug carrier in ...
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In vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line
... metabolite, 2-methoxyestradiol (2ME2) was found that exerts antiproliferative in vitro and in vivo ...namely 2-methoxyestradiol-bis-sulphamate (2MEBM) in a breast adenocarcinoma cell line ...
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Low Expression of 2-Methoxyestradiol (2-Me) on Placenta Tissue as a Risk Factor of Pre-Eclampsia
... of 2-ME was suspected to be very important in the mechanism of the ...low 2-ME expression in the placenta as a risk factors for PE and a case control study has been conducted in the department of obstetrics ...
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DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol
... including 2-ME, modify NO generation ...NOS 2, NOS II), induced by factors such as stress or inflammation; and endothelial nitric oxide synthase (eNOS, NOS 3, NOS III), expressed mainly in endothelial cells ...
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A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines
... Further studies were conducted that employed flow cy- tometry and Mitocapture Mitochondrial Apoptosis Detec- tion Kit to demonstrate the apoptosis pathway utilized by EMBS. Mitochondrial integrity was investigated by ...
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Disease modifying and antiangiogenic activity of 2 Methoxyestradiol in a murine model of rheumatoid arthritis
... Hind limbs, including the ankle joint were removed and snap frozen in liquid nitrogen. TRIzol, (1 mL; Invitrogen, Carlsbad, CA) was added to the joint, which was subse- quently homogenized using a polytron homogenizer ...
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Molecular crosstalk between apoptosis and autophagy induced by a novel 2-methoxyestradiol analogue in cervical adenocarcinoma cells
... for 10 min, then pelleted and resuspended in ice-cold PBS. Cells were permeablized with ice-cold methanol (−20°C), added in a drop-wise manner. Cells were washed twice with cold PBS. Pelleted cells were resuspended in ...
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(NH4)2[Ni(H2P2O7)2(H2O)2]
... diphosphate anion in a roughly eclipsed conformation. The average P—O distance of 1.545 A ˚ is the same as for the isotypic Co member and is comparable to the average distances observed for other diphosphates: 1.533 A ˚ ...
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(NH4)2[Co(H2P2O7)2(H2O)2]
... other through intricate hydrogen bonding, as shown in Fig. 2. There are three kinds of hydrogen bonds (see Table 2), viz. four bonds from ammonium, two from the di- hydrogendiphosphate units and another two ...
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2 (2 Bromo 4 chloroanilino) 2 phenylethanol
... 2-Phenyloxirane (1.48 g, 0.04 mol) and p-chloroaniline (5.11 g, 0.04 mol) were stirred at room temperature over a period of 24 h in the presence of a Lewis acid, in this case lithium perchlorate (0.53 g, 0.006 ...
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(±) trans 3 Benzoylbicyclo[2 2 2]octane 2 carboxylic acid
... Fig. 2 shows the packing for (I), typical for racemic keto acids that are dimeric. Centrosymmetric dimers are centered at 1/2,1/2,1/2 in the chosen cell, with a second screw-related set centered on the a ...
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Methyl 2(E) methoxyimino 2 [2 (2 methylphenoxymethyl)phenyl]acetate
... N1 0.0625 (10) 0.0481 (8) 0.0464 (9) −0.0029 (7) 0.0273 (8) −0.0002 (7) O1 0.0554 (8) 0.0589 (8) 0.0482 (7) 0.0084 (6) 0.0252 (6) 0.0154 (6) O2 0.0959 (11) 0.0538 (8) 0.0512 (8) −0.0029 (7) 0.0468 (8) −0.0017 (6) O3 ...
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Vol 2, No 2
... Kipling’s knowledge of Indian ways of life and culture is exemplified in the following references from the novel: the trains in which “the sexes are very strictly kept to separate carr[r] ...
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(2 2 2 Cryptand)potassium tetracarbonylcobaltate(−I)
... The title salt (Fig. 1) contains the classical metal carbonyl anion (Ellis, 2003) tetracarbonylcobaltate, which has now appeared in the Cambridge Structural Database (CSD, Version 5.35, update No. 2, Febuary 2014, ...
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