20S proteasome
Effect of SOD1 Overexpression on the 20S Proteasome during Aging
... the proteasome, to degrade selectively oxidized and damaged proteins [22]-[24] thus preventing their accumulation which can be deleterious in many diseases (review in: [25] ...26S proteasome consists of a ...
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A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster
... whether 20S proteasome induction is important for the adaptive ...the 20S proteasome was first knocked- down by ...four 20S subunit genes were ...the 20S proteasome ...
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HC-Pro Protein of Potato Virus Y Can Interact with Three Arabidopsis 20S Proteasome Subunits In Planta
... the 20S proteasome and affect its ac- tivity; however, exactly which subunits of the 20S proteasome are bound by HC-Pro is ...Arabidopsis 20S proteasome subunits, PAA, PBB, and ...
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The Dominant Temperature-Sensitive Lethal DTS7 of Drosophila melanogaster Encodes an Altered 20S Proteasome β-Type Subunit
... of 20S proteasomes that contain and ...sug- 20S proteasome contains two b2 subunits, this would gesting that this strain may carry a small deletion or mean that only one-fourth of the 20S ...
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Molecular Organization of the 20S Proteasome Gene Family from Arabidopsis thaliana
... Arabidopsis 20S proteasome sub- units and their counterparts in other organisms sug- gested that the Arabidopsis subunit families assume identical locations in the particle and perform similar functions ...
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The value of correlation of serum 20S proteasome concentration and percentage of lymphocytic apoptosis in critically ill patients: a prospective observational study
... as 20S proteasome which is composed of seven different a and b subunits arranged in four heptameric rings ...circulating 20S proteasome was pro- posed as a marker of cell damage and protein ...
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<p>Bortezomib sensitivity is tissue dependent and high expression of the 20S proteasome precludes good response in malignant pleural mesothelioma</p>
... a proteasome inhibitor, which has been approved for the treatment of relapsed and refractory multiple myeloma as well as relapsed mantle cell ...the 20S proteasome in human acute myeloid leukemia ...
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Circulating 20S Proteasome Levels in Patients with Mixed Connective Tissue Disease and Systemic Lupus Erythematosus
... 10). 20S proteasomes are also detectable in healthy serum and plasma, and elevated circulating 20S proteasome (c20S) concentrations have been described in several diseases, such as hematologic ...
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Protein synthesis is lowered while 20S proteasome activity is maintained following acclimation to low temperature in juvenile spotted wolffish (Anarhichas minor Olafsen)
... of proteasome at different ...the proteasome should be the same between acclimation groups and the calculated activities should represent ...for 20S proteasome and/or ubiquitinating enzymes ...
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Quantification by ELISA of serum and intracellular 20S proteasome in a healthy Moroccan population
... Le complexe catalytique Ubiquitine-Protéasome est un complexe multimérique de 2500 kDa. Il est formé d’un cœur catalytique : le protéasome 20S, qui renferme les sites protéolytiques, associé à un complexe ...
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The effect of temperature adaptation on the ubiquitin–proteasome pathway in notothenioid fishes
... proteins, 20S proteasome activity and mRNA expression of many proteins involved in both the Ub tagging of damaged proteins as well as the different complexes of the 26S proteasome were measured to ...
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Proteasome Mutants, pre4-2 and ump1-2, Suppress the Essential Function but Not the Mitochondrial RNase P Function of the Saccharomyces cerevisiae Gene RPM2
... 333–406 in The Molecular and Cellular Biology of the Yeast Saccharo- Smyth, K. A., and J. M. Belote, 1999 The dominant temperature- myces: Genome Dynamics, Protein Synthesis, and Energetics, edited by sensitive lethal ...
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Original Article Proteasome degradation of brain cytosolic tau in Alzheimer’s disease
... 30S proteasome and 26 hybrid proteasome activity on degradation of ...The 20S core has a size of 12 nm in diameter and 17 nm in height [16, 18]; the pro- teasome has an estimated Rs of 102 Å, while ...
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A Genetic Suppressor of Two Dominant Temperature-Sensitive Lethal Proteasome Mutants of Drosophila melanogaster Is Itself a Mutated Proteasome Subunit Gene
... few proteasome mutants have been identified in Drosophila, and most are severe loss-of- function alleles that act as recessive, embryonic, or early larval ...6 20S proteasome subunit genes have been ...
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Hereditary profiles of disorderly transcription?
... While I commend the author for tackling such complex questions, I do not agree with many of the conclusions and believe the study is compromised by inadequate assumptions and data selection. My main concerns are: 1) The ...
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Synthetic Analogs of Green Tea Polyphenols as Proteasome Inhibitors
... identical proteasome-inhibitory prop- erties and therefore only the commercial ( )-GCG was used in the experiments presented in this ...Purified 20S proteasome (Methanosarcina thermophile, ...
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Chemical tools to probe the proteasome
... The proteasome inhibitors PS-341 (29, bortezomib), salinosporamide A (3, NPI- 0052) and the epoxyketone carfilzomib (46) have been studied extensively for their antineoplastic activity (Figure ...of ...
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Hsp90 and ECM29 Are Important to Maintain the Integrity of Mammalian 26S Proteasome
... 26S proteasome complex in yeast, we focused on the proteasome ...the proteasome, we ran a glycerol density gradient centrifugation experiment (GDGC) with WT and ECM29 deficient cell lysates fol- ...
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Biochemical and biophysical characterization of compartmentalizing proteases from the hyperthermophilic microorganism Pyrococcus furiosus
... assays. Proteasome peptidase activity was determined with a microtiter plate reader (Model HTS 7000 Plus Bio Assay Reader, Perkin-Elmer, Wellesley, MA) by detection of 7-amino-4-methylcoumarin (MCA) released from ...
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Ubiquitin proteasome system dysfunction in experimental models of Parkinson's disease
... for proteasome inhibition (Moore et ...However, proteasome inhibition and nigrostriatal degeneration are markedly attenuated in α-synuclein knockout mice (Fornai et ...that proteasome inhibition ...
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