3-d]pyrimidine derivatives
![Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
... its elemental and spectral data (Scheme 4). Furthermore, treatment of compound 14 with aryl aldehydes 4a–b yielded arylmethylene hydrazide derivatives 22a–b in quantitative yields [39]. Acylation of 22a–b using ...
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Studies on synthesis and antimicrobial activity of 2 amino 1 cyanobenzopyrano[4,3 d]pyrimidine derivatives
... related pyrimidine, due to the interaction of several drugs, receptor binding models, which enabled a systematic and rational design of novel inhibitors of various enzymes, such as HIV protease [1] and DNA gyrase ...
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Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety
... In the course of finding novel chemical agents that may serve as innovative antitumor agents, quinazoline de- rivatives are of particular interest [5]. In the last few years, the thieno[2,3-d]pyrimidine ...
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DISCOVERY OF SUBSTITUTED IMIDAZO [1, 2 c] PYRIDO [3, 2 e] PYRIMIDINE BASED DERIVATIVES AS NOVEL ANTI MICROBIAL AGENTS
... All chemical were purchased from Sigma Aldrich with purity not less than 99.9%. Analytical Thin Layer Chromatography (TLC) was carried out by using silica gel 60 F254 pre-coated plates. Visualization was accomplished ...
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Synthesis, reactivity and antitumor activity of some new pyrazolo[3,4-d] pyrimidine and their triazole derivatives
... Five grams of compound 2 and 10 g urea were heated together at 180-190°C for 15 min. The resulting solid was dissolved in dilute sodium hydroxide and then carefully acidified with acetic acid to obtain 4 g of crude ...
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Therapeutic potential of heterocyclic pyrimidine scaffolds
... pyrazolo[3,4-d] pyrimidine derivatives. The synthesized derivatives were analyzed for N content and their structures were con- firmed by IR, NMR and Mass spectral data and screened their ...
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Synthesis, characterization and antihyperlipidemic activity of novel condensed pyarazolo [3,4 d]pyrimidine derivatives
... 2.2.2 Synthesis of the 6-chloromethyl-3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one(6)[15] Mixture of 5-amino-4-carbaxamido-3-(methylthio)-1-phenylpyrazole(4, 2 g, 0.008 mol) and ...
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Tandem Knoevenagel-Michael-cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives using isonicotinic acid as an efficient catalyst
... pyrano[2,3-d]pyrimidine dione derivatives. Various aromatic aldehydes containing electron-with drawing substituents, electron- releasing substituents and halogens on their aromatic rings were used ...
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Synthesis and Biological Studies of 1, 2, 3, 4-Tetrahydro Pyrimidine Derivatives
... A., Molecules, 8: 381 (2003), Stadler, A., Yousefi, B. H., Dallinger, D., Walla, P., Van der Eycken, E., Kaval, N., Kappe, C. O., Org. Process Res.Dev., 7: 707 (2003), Stadler A., Kappe, C. O., J. Comb. Chem, ...
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Green approach for synthesizing Pyrimido pyrimidine moieties using TBAB
... Pyrimido[4,5-d]pyrimidine derivatives are well known as bronchodilators [12], vasodilators [13], antiallergic [14], antihypertensive [15], and anticancer [16] ...
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Synthesis, Cytotoxicity, Xanthine Oxidase Inhibition, Antioxidant of New Pyrazolo{3,4 d}Pyrimidine Derivatives
... 2. Matteus KR, Lars CN, Eric N VA. simple method for quantification of allopurinol and oxipurinol in human serum by high-performance liquid chromatography with UV-detection. J Ph B A. 2007; 45 (2): 312–317. 3. ...
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Synthesis, characterization and pharmacological evaluation of pyrimidine and its derivatives for their anticancer activity.
... Claudio N. Cavasotto et al., 123 reported inhibition of the epidermal growth factor receptor (EGFR) tyrosine kinase activity by small molecules has proved effective for the treatment of cancer. To the best of our ...
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Synthesis, Characterization and In Vitro Antitumor Evaluation of New Pyrazolo[3,4 d]Pyrimidine Derivatives
... synthesized derivatives were evaluated for antitumor activity by measuring the inhibitory effect of such compounds against human breast ade- nocarcinoma cell line MCF7 using MITT technique [21] ...
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Synthesis of Some Pyrimidine and Fused Pyrimidine Derivatives with Antimicrobial and Anticancer Activities
... of pyrimidine and fused pyrimidine derivatives was ...pyrimidyl derivatives were constructed from the key intermediates pyrimidyl hydrazine ...[4,3-a] pyrimidine, pyrido [2,3-d] ...
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SYNTHESIS OF PYRIMIDINE DERIVATIVES AND THEIR ANTICONVULSANT ACTIVITY
... 14. Gangjee A, Vidwans A, Elzein E, McGuire JJ, Queener SF, Kisliuk RL. () Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted- pyrrolo[2,3-d]pyrimidines. ...
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H NMR, 13 C NMR, mass spectra and elemental analysis. All the
... Different pyrimidine derivatives containing a phenothiazine nucleus were synthesized under reflux ...of 3-methyl-1-(10H- phenothiazin-8-yl)-1H-pyrazol-5(4H)-one (3), an appropriate aldehyde ...
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A Facile Synthesis and Docking Studies of N-(3-(4-Chlorophenoxy)benzyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
... the pyrimidine nucleous: pyrrolo[2.3-d]pyrimidine, ...pyrrolo[3.4- d]pyrimidine, pyrrolo[1.2-a]pyrimidine and ...aminopyrroles. Pyrimidine derivatives have occupied ...
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Synthesis and Characterization of Pyrimidine Containing Thiazolidinedione derivatives
... 2. Hong, Woo Lee; Bok, Young Kim; Joong, Bok Ahn; Sung, Kwon Kang; Jung, Hwa Lee; Jao, Soo Shin; Soon, Kil Ahn and Sang, Joon Lee. Molecular design, synthesis, and hypoglycemic and hypolipidimic activities of novel ...
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Synthesis, molecular docking and ADME prediction of some pyridine and pyrimidine derivatives as anti colorectal cancer drugs
... Molecular docking is a key tool in structural molecular biology and computer assisted drug design. The goal of ligand–protein docking is to predict the predominant binding mode(s) of a ligand with a protein of known ...
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Synthesis, characterization, and antimicrobial activity of pyrazol 3 yl pyrimidine, pyrazole and pyran derivatives
... pyran derivatives were synthesized by one step synthesis involving three component ...thecompounds 3, 4, 5, 11, 14, 16 and 18 showed slight activity towards Staphyllococcus aureus as Gram positive strain ...
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