3-hydroxy-3-methylglutaryl
Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3 hydroxy 3 methylglutaryl coenzyme A reductase
... 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase catalyzes the formation of mevalonate, an essential precursor for isoprenoid compounds in mammalian cells. Recent studies have shown ...
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Severe clinical manifestation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency associated with two novel mutations: a case report
... Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHS) deficiency is an autosomal recessive inborn error of metabolism, which will give rise to failure of ketogenesis in liver during ...
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Identification of a Highly Expressed 3 Hydroxy 3 Methylglutaryl CoA Reductase Gene in the Root Tissue of Taraxacum kok saghyz
... The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme catalyzes the conversion of 3-hydroxy-3-methylglutaryl-CoA to meva- lonic acid, a key regulatory step in ...
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Regulation of acylcoenzyme A Cholesterol acyltransferase and 3 hydroxy 3 methylglutaryl coenzyme A reductase activity by lipoproteins in the intestine of parabiont rats
... (3- hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase activity) and esterification (acylcoenzyme A/cholesterol acyltransferase [ACAT] activity) by lipoproteins and micellar ...
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INHIBITION OF 3 HYDROXY 3 METHYLGLUTARYL COENZYME A (HMG Co A) REDUCTASE IN LIVER MICROSOMES BY MORINGA OLEIFERA L POLYPHENOLS
... of 3-hydroxy-3-methylglutaryl Coenzyme A (HMG CoA) reductase was studied using a spectrophotometric assay based on the stoichiometric formation of coenzyme A (SH) during the reduction of ...
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Differential expression of 3 hydroxy 3 methylglutaryl coenzyme A reductase of Andrographis paniculata in andrographolide accumulation
... initially 3-hydroxy-3-methylglutaryl- coenzyme A reductase (hmgr1), a pathway regulatory enzymes was selected for estimating the gene expression and association analysis with andrographolide ...
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Regulation of 3 hydroxy 3 methylglutaryl coenzyme A reductase activity in murine epidermis Modulation of enzyme content and activation state by barrier requirements
... Epidermal cholesterol biosynthesis is regulated by barrier function. We quantitated the amount and activation state (phosphorylation-dephosphorylation) of the rate-limiting enzyme, ...
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Control of 3 Hydroxy 3 Methylglutaryl CoA Reductase Activity in Cultured Human Fibroblasts by Very Low Density Lipoproteins of Subjects with Hypertriglyceridemia
... Very low density lipoproteins (VLDL) and low density lipoproteins (LDL) from human normolipemic plasma, and the VLDL, the intermediate density lipoprotein (IDL), and LDL from patients with Type III hyperlipoproteinemic ...
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Identification of 3 methylglutarylcarnitine A new diagnostic metabolite of 3 hydroxy 3 methylglutaryl coenzyme A lyase deficiency
... only 3-methylglutaryl-CoA is a substrate for acylcarnitine ...Neither 3-methylglutaconyl-CoA nor 3-hydroxy-3-methylglutaryl- CoA are excreted as ...of ...
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Cholesterol lowering effect of mevinolin, an inhibitor of 3 hydroxy 3 methylglutaryl coenzyme a reductase, in healthy volunteers
... Mevinolin reduces cholesterol synthesis by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The safety and effectiveness of this agent was evaluated in a double-blind, ...
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MR imaging and proton spectroscopy in 3 hydroxy 3 methylglutaryl coenzyme A lyase deficiency
... of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) lyase is an inborn error of leucine degradation and ketone body synthesis ...of 3-hydroxyisovaleric acid, 3-methylglutaric ...
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3 Hydroxy 3 methylglutaryl coenzyme A reductase in anencephalic and normal human fetal liver
... of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the primary rate- limiting enzyme of cholesterol biosynthesis, in anencephalic liver and normal fetal ...
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56. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ex vivo) by medicinal plants from western ghats
... 3-Hydroxy- 3-methylglutaryl Coenzyme A reductase, the enzyme that synthesizes mevalonate, appears to be regulated through a multivalent feedback ...
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Molecular Characterization of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (HMGR) in Grass Carp Ctenopharyngodon idellus and Its Regulation by Oxidized Fish Oil
... 2015). 3- Hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGR) is a rate-limiting enzyme for cholesterol biosynthesis, catalyzing conversion of HMG-CoA to mevalonic acid (Norambuena et ...
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Feedback Regulation of 3 Hydroxy 3 Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase
... 2 h after mevalonate administration to mevinolin-treated mice on a control diet, the total HMG CoA reductase activity i.e., that present after alkaline phosphatase treatment had declined[r] ...
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Original Article Effect of atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor (HMG-CoA) on the prevention of osteoporosis in ovariectomized rabbits
... Statins, 3-hydroxy 3-methyl glutaril coenzyme A (HMG-CoA) reductase inhibitors, were first developed to control and treat patients with hyperlipidemia and hypercholesterolemia ...
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In vivo regulation of human mononuclear leukocyte 3 hydroxy 3 methylglutaryl coenzyme A reductase Decreased enzyme catalytic efficiency in familial hypercholesterolemia
... We measured HMG CoA reductase protein concentration and microsomal enzyme activity in freshly isolated mononuclear leukocytes from normal individuals and patients with heterozygous or ho[r] ...
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The regulation of 3 hydroxy 3 methylglutaryl coenzyme A reductase in the isolated perfused rat liver
... coenzyme A reductase was studied. In liver removed during the basal period of the diurnal cycle of enzyme activity, a 227 +/- 41% increase in enzyme activity occurred after 3 h of a plasma-free perfusion. This ...
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In vivo regulation of human mononuclear leukocyte 3 hydroxy 3 methylglutaryl coenzyme A reductase Studies in normal subjects
... In this report we demonstrate that mononuclear leukocyte HMG CoA reductase exhibits a diurnal rhythm in activity, is inhibited by fasting and cholesterol feeding, is stimulated by rapid [r] ...
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Management and long-term evolution of a patient with 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency
... At 14 years of age, he returned to our Pediatric Emer- gency Department due to a loss of consciousness follow- ing vomiting brought on by alcohol consumption a few hours before (3 vodkas with coke). The family ...
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