3-hydroxy-3-methylglutaryl coenzyme A
Regulation of acylcoenzyme A Cholesterol acyltransferase and 3 hydroxy 3 methylglutaryl coenzyme A reductase activity by lipoproteins in the intestine of parabiont rats
... (3- hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase activity) and esterification (acylcoenzyme A/cholesterol acyltransferase [ACAT] activity) by lipoproteins and micellar ...
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56. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ex vivo) by medicinal plants from western ghats
... 3-Hydroxy- 3-methylglutaryl Coenzyme A reductase, the enzyme that synthesizes mevalonate, appears to be regulated through a multivalent feedback ...
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Cholesterol lowering effect of mevinolin, an inhibitor of 3 hydroxy 3 methylglutaryl coenzyme a reductase, in healthy volunteers
... Mevinolin reduces cholesterol synthesis by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The safety and effectiveness of this agent was evaluated in a double-blind, ...
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Differential expression of 3 hydroxy 3 methylglutaryl coenzyme A reductase of Andrographis paniculata in andrographolide accumulation
... initially 3-hydroxy-3-methylglutaryl- coenzyme A reductase (hmgr1), a pathway regulatory enzymes was selected for estimating the gene expression and association analysis with ...
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INHIBITION OF 3 HYDROXY 3 METHYLGLUTARYL COENZYME A (HMG Co A) REDUCTASE IN LIVER MICROSOMES BY MORINGA OLEIFERA L POLYPHENOLS
... of 3-hydroxy-3-methylglutaryl Coenzyme A (HMG CoA) reductase was studied using a spectrophotometric assay based on the stoichiometric formation of coenzyme A (SH) during the ...
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Regulation of 3 hydroxy 3 methylglutaryl coenzyme A reductase activity in murine epidermis Modulation of enzyme content and activation state by barrier requirements
... Epidermal cholesterol biosynthesis is regulated by barrier function. We quantitated the amount and activation state (phosphorylation-dephosphorylation) of the rate-limiting enzyme, ...
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Identification of 3 methylglutarylcarnitine A new diagnostic metabolite of 3 hydroxy 3 methylglutaryl coenzyme A lyase deficiency
... of 3-hydroxy-3-methylglutaryl-coenzyme A (CoA) lyase affects the metabolism of leucine as well as ...proven 3-hydroxy-3-methylglutaryl-CoA lyase deficiency ...
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MR imaging and proton spectroscopy in 3 hydroxy 3 methylglutaryl coenzyme A lyase deficiency
... Summary: Three patients with 3-hydroxy-3-methylglutaryl coenzyme A lyase deficiency were examined with MR im- aging and proton MR spectroscopy. In two patients, both clinically normal, ...
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Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3 hydroxy 3 methylglutaryl coenzyme A reductase
... 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase catalyzes the formation of mevalonate, an essential precursor for isoprenoid compounds in mammalian cells. Recent studies have ...
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Molecular Characterization of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (HMGR) in Grass Carp Ctenopharyngodon idellus and Its Regulation by Oxidized Fish Oil
... 2015). 3- Hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGR) is a rate-limiting enzyme for cholesterol biosynthesis, catalyzing conversion of HMG-CoA to mevalonic acid (Norambuena et ...
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3 Hydroxy 3 methylglutaryl coenzyme A reductase in anencephalic and normal human fetal liver
... of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the primary rate- limiting enzyme of cholesterol biosynthesis, in anencephalic liver and normal fetal ...
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Feedback Regulation of 3 Hydroxy 3 Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase
... 2 h after mevalonate administration to mevinolin-treated mice on a control diet, the total HMG CoA reductase activity i.e., that present after alkaline phosphatase treatment had declined[r] ...
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Role of lipoprotein X in the pathogenesis of cholestatic hypercholesterolemia Uptake of lipoprotein X and its effect on 3 hydroxy 3 methylglutaryl coenzyme A reductase and chylomicron remnant removal in human fibroblasts, lymphocytes, and in the rat
... Calculated on the basis of gram wet weight, spleen took up more LP-X than liver. Prior ligation of the bile duct reduced the uptake in spleen. Experiments with isolated perfused rat liver showed that nonparenchymal cells ...
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Original Article Effect of atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor (HMG-CoA) on the prevention of osteoporosis in ovariectomized rabbits
... Statins, 3-hydroxy 3-methyl glutaril coenzyme A (HMG-CoA) reductase inhibitors, were first developed to control and treat patients with hyperlipidemia and hypercholesterolemia ...
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In vivo regulation of human mononuclear leukocyte 3 hydroxy 3 methylglutaryl coenzyme A reductase Studies in normal subjects
... In this report we demonstrate that mononuclear leukocyte HMG CoA reductase exhibits a diurnal rhythm in activity, is inhibited by fasting and cholesterol feeding, is stimulated by rapid [r] ...
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In vivo regulation of human mononuclear leukocyte 3 hydroxy 3 methylglutaryl coenzyme A reductase Decreased enzyme catalytic efficiency in familial hypercholesterolemia
... We measured HMG CoA reductase protein concentration and microsomal enzyme activity in freshly isolated mononuclear leukocytes from normal individuals and patients with heterozygous or ho[r] ...
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The regulation of 3 hydroxy 3 methylglutaryl coenzyme A reductase in the isolated perfused rat liver
... coenzyme A reductase was studied. In liver removed during the basal period of the diurnal cycle of enzyme activity, a 227 +/- 41% increase in enzyme activity occurred after 3 h of a plasma-free perfusion. ...
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Low density lipoprotein receptor and 3 hydroxy 3 methylglutaryl coenzyme A reductase gene expression in human mononuclear leukocytes is regulated coordinately and parallels gene expression in human liver
... +/- 3 x 10(4)/micrograms of RNA) and mononuclear leukocytes (24 +/- 3 x 10(4)/micrograms of RNA) are indistinguishable, whereas the number of HMG CoA reductase molecules in liver (107 +/- 15 x ...
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Management and long-term evolution of a patient with 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency
... At 14 years of age, he returned to our Pediatric Emer- gency Department due to a loss of consciousness follow- ing vomiting brought on by alcohol consumption a few hours before (3 vodkas with coke). The family ...
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A neonatal case of 3-hydroxy-3-methylglutaric-coenzyme A lyase deficiency
... of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) lyase, an enzyme catalyzing the cleavage of HMG-CoA to acetyl-CoA and acetoacetic acid, leading to the common final step of ketogenic ...
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