4-Dihydropyridine
QSAR STUDIES ON NOVEL 1, 4 DIHYDROPYRIDINE DERIVATIVES
... -diphenyl-1, 4- dihydropyridine-3, 5-dicarbohydrazides [2A-2D’] and 2, 6-dimethyl- 1,4-dihydro-pyridine-3, 5-yl-bis[carbonyl-2-(phenyl)]pyrazolidine-3, 5-diones] [3A -3D’] were carried ...
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Anticonvulsant, analgesic and anti inflammatory activities of some novel pyrrole and 1,4 dihydropyridine derivatives
... In this work we reported the synthesis some pyrrole and 1,4-dihydropyridine derivatives and evaluation of pharmacological activity. Synthesized compounds were confirmed by IR, ¹H NMR, 13 C NMR, Mass spectral and ...
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Synthesis and biological screening of 1,4 dihydropyridine derivatives containing benzothiazolyl moiety
... MTT assay method used for Antiproliferative activity against Human hepatoma cell line (hepatic cancer) and Human breast adinocarcinoma cell line (breast cancer) and their results were summarized in Table 6 and 7. ...
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Synthesis of Novel 1,4- Dihydropyridine Derivatives Bearing Biphenyl-2'-Tetrazole Substitution as Potential Dual Angiotensin II Receptors and Calcium Channel Blockers
... novel 4-[2 ΄ -(carboxylic acid)biphenyl-4-yl] imidazolyl-1,4-dihydropyridine-3,5-dicarboxylates as potential dual acting angiotensin II inhibitors and calcium channel ...
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Synthesis and anticonvulsant activity of a new series of 1,4-dihydropyridine derivatives
... percentage yields of all compounds are summarized in Table 2. The IR spectrum of the compounds (1a-g) showed an absorption band at 3332 to 3354 cm־¹ due to the NH stretching, and another absorption band at 1741-1764 cm־¹ ...
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SYNTHESIS AND CHARACTERIZATION OF 2,6-DICHLORO-1-(NSUBSTITUTED PHENYL)-1,4-DIHYDROPYRIDINE-3,5- DICARBALDEHYDES AND THEIR TRANSFORMATION INTO EFFECTIVE ANTIFUNGAL 4-THIAZOLIDINONE DERIVATIVES
... of 4-thiazolidinone derivatives, we wanted to develop an innovative synthesis of 4- thiazolidinone derivatives from 2,6-dichloro-1-(N- substituted phenyl)-1,4-dihydropyridine-3,5- ...
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Synthesis and Antitubercular Activity of N3,N5-Diaryl-4-(5-arylisoxazol-3-yl)-1,4-dihydropyridine-
... The development of a reproducible screening procedure for tuberculosis infection permitted to introduce 1,4-DHPs as a prototype of anti-tuberculosis agents [6]. It could be seen from pervious study [5] that an aryl-amid ...
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SYNTHESIS, CHARACTERIZATION AND DEVELOPMENT OF VALIDATED RP HPLC METHOD FOR THE ESTIMATION OF PROCESS RELATED IMPURITY DIETHYL 4 (4 CHLOROPHENYL) 2, 6 DIMETHYL 1, 4 DIHYDROPYRIDINE 3, 5 DICARBOXYLATE FROM AMLODIPINE BULK AND FORMULATION
... The research subscribed in this article is directed towards the identification of process related impurities from Amlodipine drugs and formulation. The identified impurities are then synthesized and the structure of the ...
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VIRTUAL TOXICITY STUDIES OF NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES
... All the derivatives except 3C showed the computed probability value less than 0.7 and negative discriminant scores are not likely to produce a positive response in an experimental assay and negative contribution to the ...
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An efficient One pot Synthesis of 1, 4 Dihydropyridine Derivatives under Solvent free Condition
... 1, 4 dihydro pyridine 3, 5 dicarboxylate derivatives are widely used for the treatment of cardiovascular disease (hypertension angina pectoris infraction) ...1, 4 dihydro pyridines have different ester ...
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Synthesis and establishment of Amlodipine impurity G reference standard
... The regulatory agencies and pharmaceutical industries are of increasing concern to the impurities affecting safety, efficacy, and quality of pharmaceutical products. The impurities were to be formed from starting with ...
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Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives
... Many X-ray structural analysis and calculation of 1,4-dihydropyrimidine ring conformation showed preference for the boat form of the 1,4-dihydropyridine ring conformation with the 4-aryl substituent in the ...
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One Pot Multi Component Synthesis of Novel Dihydropyridine Derivatives
... The development of efficient and versatile catalytic systems for Hantzsch reaction is an active on-going research area and thus, there is a scope for further improvement toward milder reaction conditions, variations of ...
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A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
... 1,4-Dihydropyridines (1,4-DHPs) are core structure of many bioactive compounds which include vasodilator, bronchodilator, anticonvulsant, antidepressive, antianxiety, analgesic, antitumoral, hypnotic and ...
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SYNTHESIS, CHARACTERIZATION AND DOCKING STUDIES OF SOME NOVEL DIHYDROPYRIDINE DERIVATIVES
... Dihydropyridine derivatives (DHPs) form a class of heterocyclic compounds with interesting pharmacological and biological properties. [1] It is well known that the DHP nucleus serves as the scaffold of important ...
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Synthesis and Biological Evaluation of Some Heterocyclic Derivatives of N Aryl 3 Cyclopropyl 3 Oxo Propanamide Analogue
... Dihydropyridine derivatives like some new Methyl-5-arylamido-4-(o-chlorophenyl)-6-cyclopropyl-2-methyl-1,4-dihydropyridine-3- carboxylate derivatives of type (2a-l) have been synthesized by the ...
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International Journal of Emerging Technology and Advanced Engineering Website: www.ijetae.com (ISSN 2250-2459, ISO 9001:2008 Certified Journal, Volume 9, Issue 5, May 2019)
... 1,4- dihydropyridine (1,4-DHP) by reacting the aldehyde, β- ketoester and ammonia and gave an important ring to medicinal chemistry ...the dihydropyridine ring has five regioisomers, the 1,2- and ...
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Efficient Procedure for Preparation of 1,4-Dihydropyridines under Green Chemistry Conditions
... Observing the biological and medicinal properties of these 1,4-dihydropyridine derivatives, herein an efficient, economic, straightforward multicomponent reaction involving ethylacetoacetate, arylaldehyde and ...
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Synthesis, crystal structure and Hirshfeld surface analysis of diethyl 2,6 dimethyl 4 (thiophen 3 yl) 1,4 dihydropyridine 3,5 dicarboxylate
... A search of the Cambridge Structural Database (CSD, Version 5.40, update of May 2019; Groom et al., 2016) for diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate derivatives with a ring substituent at C4 ...
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Novel procedure for preparation of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
... An efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three- component reaction of various aldehydes, ethyl acetoacetate, ...
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