4-dihydropyridines
Synthesis, Charecterisation and biological Evaluation of Novel Hantzsch 1,4 dihydropyridines
... Dihydropyridines (Eisner and Kuthan, 1972; Stout and Meyers, 1982; Kappe, 1993, 2003) represent important and extensively studied compounds belonging to the class of calcium channel blockers. Many researchers have ...
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Synthesis of some Novel N-Aryl-1,4-Dihydropyridines Derivatives and Their Biological Evaluation as Potential Antimycobaceterial Agents Amish P. Khamar
... Tuberculosis, due to its unyielding nature, is now a chief civic health threat. The associated renaissance of TB with the MDR or XDR-TB and HIV/AIDS epidemic has exposed the infirmities of the current drug armatorium. ...
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Efficient Procedure for Preparation of 1,4-Dihydropyridines under Green Chemistry Conditions
... A simple, straightforward and economical method has been described for synthesis of 1,4-dihydropyridines. This method offers advantages in terms of mild experimentation conditions, economic catalyst, good to ...
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Silica Boron Sulfonic Acid as Heterogeneous and Highly Efficient Solid Acid Catalyst For the Preparation of Hantzsch 1,4-dihydropyridines Under Solvent-Free
... 14. Kolvari E., Zolfigol M.A., Koukabi N., and Shirmardi- Shaghasemi B. A simple and efficient one-pot synthesis of hantzsch 1,4-dihydropyridines using silica sulphuric acid as a heterogeneous and reusable ...
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A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
... 1,4-Dihydropyridines (1,4-DHPs) are core structure of many bioactive compounds which include vasodilator, bronchodilator, anticonvulsant, antidepressive, antianxiety, analgesic, antitumoral, hypnotic and ...
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One pot synthesis, antibacterial, dna photocleavage and sar studies of some fused 1,4 dihydropyridines via symmetrical hantzsch condensation
... The chemistry of 1,4-dihydropyridines (1,4-DHPs) found birth in 1882 with Hantzsch condensation (Hantzsch, 1882). After Hantzsch, multifarious new methods have been nurtured for the synthesis of original compounds ...
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Novel procedure for preparation of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
... PEG, (polyethylene glycol), is known to be inexpensive, thermally stable, recoverable, biological compatible, and non-toxic [19]. Their potential as reaction media and promotor for organic reaction has attracted the ...
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Highly Efficient, One Pot Synthesis and Oxidation of Hantsch 1,4 Dihydropyridines Mediated by Iodobenzene Diacetate (III) Using Conventional Heating, Ultrasonic and Microwave Irradiation
... 1,4-Dihydropyridines (1,4-DHPs) belong to a class of nitrogen containing heterocycles having a six-mem- bered ring. Much attention has been devoted to explore their pharmacological activities. A considerable ...
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TiCl2/Nano-γ-Al2O3 as a Novel Lewis Acid Catalyst for Promotion of One-pot Synthesis of 1,4-dihydropyridines
... In recent years, one-pot multicomponent reactions (MCRs) have been extensively studied for their simple procedures, high selectivity, and superior atom economy. Contrary to the classical methods to synthesize complex ...
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2D QSAR Studies on 1, 4 dihydropyridines as Ca++ Channel Blockers
... In the present study a 2-D QSAR model has been developed for correlating activity of 1, 4- dihydropyridines as calcium channel blockers with physicochemical properties. The developed model is found to be ...
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Al(DS)3 Catalyzed, One pot Synthesis and Antibacterial Studies of tetra substituted 1,4 Dihydropyridines in Aqueous Media
... 1,4-dihydropyridines (1,4-DHP’s) found birth with MCRs in 1882 with Hantzsch condensation [3]. 1,4-DHP’s attracted more attention because of its presence in the coenzyme, diphosphopyridine nucleotide (DPNH) ...
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Synthesis, characterization and pharmacological evaluation of some 1,4 dihydropyridines derivatives
... . On the molecular level 1,4-dihydropyridine compounds causes vaso relaxation by blocking voltage operated calcium channel in smooth muscle cell and also by increasing no release from intact endothelium 5 . The ...
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Synthesis, Characterization and In-Vitro Anti-Oxidant Activity of Some 1,4-Dihydropyridines and their Mannich Bases.
... derivative of pyridine. They are particularly well known in pharmacology as L-type calcium channel blockers. They are readily convertible to pyridines and are important role as intermediates in reactions of pyridine e.g ...
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Green Synthesis and Characterization of Bi2O3 Nanorods as Catalyst for Aromatization of 1,4-Dihydropyridines
... to successfully catalyse the Hantzsch aromatization of 1,4-DHPs. The effect of the amount of catalyst and time on aromatization of 1,4 dihydro-4-phenyl-2,6 dimethyl- 3,5 pyridinedicarboxylate designated as 1,4-DHP ...
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Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines
... from surface wounds, blood, and throat, were used to deter- mine the killing activity against Gram-positive bacteria. The lowest MIC values (predominantly 64 μ g/mL) among 1,4-DHP derivatives in nonimmobilized form were ...
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SYNTHESIS OF 4-(1-BENZYL-5-IMIDAZOLYL)-1,4-DIHYDROPYRIDINES
... To a stirring suspension of 1 (5 g, 22.72 mmol) in methanol (372 mL) was added sodium hydroxide (1 N, 23.5 mL) at room temperature. The resulting mixture was stirred for 10 min until a clear pale yellow solution was ...
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Zn[(L)-proline]‚ as a Recyclable and Green Catalyst for Efficient and One-pot Three-Component Synthesis of 1,4-Dihydro- pyridines Under Solvent-Free and Microwave Irradiation Conditions
... Zn[(L)-proline]‚ was faund to be efficient, green, and recyclable catalyst for the synthesis of 1,4-dihydropyridines by condensation reaction of aldehydes, ethyl acetoacetate, and ammonium acetate in high to ...
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“Design and Molecular Docking Studies of Some 1,3,4-Oxadiazole Derivatives” by Dinesh Rishipathak, Prabhakar Shirodkar, India.
... 1,3, 4-oxadiazoles containing hydantoins and 1,4-dihydropyridines were done using V life MDS Biopredicta module using cavity # 1 of open channel voltage gated Sodium channel protein (4F4L) and Crystal ...
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A REVIEW ON THE SYNTHESIS AND BIOLOGICAL ACTIVITIES OF PIPERIDIN 4 ONES K P Greeshma * and S Muthulingam
... Ethyl acetoacetate and ethyllevulinate have also been employed as the ketone component for the synthesis of piperidine-4-ones (Scheme 7a) 13, 31-34 . With ethyl acetoacetate, aromatic aldehyde gave ...
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Developing lithium chemistry of 1,2-dihydropyridines : from kinetic intermediates to isolable characterized compounds
... lithio dihydropyridines have been touched upon here, the fact that these complexes are easily synthesized and (some) exhibit excellent solubility, suggest their application as transporters of molecular LiH will ...
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