4-thiadiazoles
![ONE-POT SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF 2-AMINO-5-ARYL-5H-THIAZOLO [4,3-b]-1,3,4-THIADIAZOLES](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
ONE-POT SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF 2-AMINO-5-ARYL-5H-THIAZOLO [4,3-b]-1,3,4-THIADIAZOLES
... aryl5 H-thiazolo[4,3-b]-1,3,4-thiadiazoles (5a-j) (Scheme 1) from equimolar quantities of an aromatic aldehyde, thioglycolic acid, and thiosemicarbazide. The interaction between equimolar quantities of aromatic ...
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Synthesis and Antimicrobial Activity of Some 2-[(4-Substituted-Phenyl-3-Chloro-Azetidin-2-One)-5-(2'-Methylamino-4-Phenyl-1', 3'-Thiazolyl-]-1, 3,4-Thiadiazoles
... 2-[(4-substituted-phenyl-3-chloroazetidin-2-one)-5-(2'-methylamino 4- phenyl-1', 3'-thiazolyl-]-1, 3, 4-thiadiazoles, 5(a-n) were synthesized from 2- ...
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Synthesis and antioxidant activity of disubstituted 1,3,4 oxadiazoles, 1,3,4 thiadiazoles and 1,2,4 triazoles
... Amongst different five membered heterocyclic systems oxadiazole, thiadiazole, triazole and their derivatives have gained importance as they constitute the structural features of many bioactive compounds. Substituted ...
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Synthesis, Characterization and Anticonvulsant Activity of Novel Fused 1,2,4-Triazolo-1,3,4-Thiadiazoles
... Literature review reveals that substituted triazolo-thiadiazoles were not given careful thought for antiepileptic drug actions. Therefore, it was thought to plan and synthesize a combination of ...
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A Novel Series of Thiazoles and 1,3,4-Thiadiazoles Bearing Thiazole Moiety as Anticancer Agents: Synthesis, Spectral Studies, Biological Evaluation and Structure Activity relationship
... The presence of the thioamidehydrazine moiety as a side chain in compound 3 prompted us to utilize it for constructing 1,3,4-thiadiazole ring via its reaction with hydrazonoyl chlorides. Thus, reaction of compound 3 with ...
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Synthesis, Antimicrobial, Antioxidant and Molecular Docking Study of Some Novel Bis-1, 2, 4-Triazolo [3, 4-b]-1, 3, 4-Thiadiazoles
... Previous studies suggested that the presence of pyrazole and triazolothiadiazole pharmacophore plays an important role in the enhancement of pharmacological activity. Encouraged by these findings and aiming at ...
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Synthesis, characterization and anticancer activity of 1,2,4 Triazolo [3,4 b] 1,3,4 thiadiazoles on Hep G2 cell lines
... A series of 3,6-disubstituted 1,2,4–triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized from 3- substituted-4-amino-5-mercapto-1,2,4-triazoles and 3-substituted 4-carboxypyrazoles. Elemental ...
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Synthesis of Fluoro Substituted Benzothiazoles Incorporated with 1,3,4-Thiadiazoles for Biological and Pharmacological Screening
... 7. Jag Mohan, Diksha Khatter, Shivayogi Hetrocyclic system containing bridehead nitrogen atom: synthesis and evaluation of bioactivity of s-triazolo [3,4-b][1,3,4] thiadiazoles,s-triazolo [3,4-b] thiadiazines. Ind ...
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Synthesis, antimicrobial activities and structure activity relationship of some dithiocarbazinate, 1,2,4 triazoles and 1,2,4 triazolo[3,4b][1,3,4]thiadiazoles
... afforded 4-amino-5-aryl-4H-1, 2, 4-triazole-3-thiol ...2, 4-triazole-3-thiol) with MIC (Minimum Inhibitory Concentration) ...2, 4]-triazolo [3, 4-b] [1, 3, 4] thiadiazole) with ...
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2 Substituted 5 (5 nitro furan 2 yl) 1,3,4 thiadiazoles: Anti Helicobacter pylori activity evaluation and docking study
... Helicobacter pylori causes gastric and gastroduodenal ulcer disease and chronic infection of H. pylori is attributed to adenocarcinoma. 2-Substituted-5-(nitro-aryl)-1,3,4-thiadiazoles are being extensive evaluated ...
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Synthesis and antimicrobial activity of phthalazine substituted 1,2,4 triazolo [3,4 b] 1,3,4 thiadiazoles and 7H [1,2,4]triazolo[3,4 b][1,3,4]thiadiazines
... In this article we report the synthesis of a new 6-chloropyridin-3-yl)methyl substituted phthalazine 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles (6a-f) and 7H-[1,2,4]triazolo[3,4- b][1,3,4]thiadiazines (7a-f) ...
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Synthesis and biological evaluation of some 1, 3, 4 thiadiazoles
... 3, 4-thiadiazoles and their derivatives exhibit a wide variety of biological activities like antidiabetic, anti inflammatory, anti-convulsants1, 2, 3 ...
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Synthesis of new -1,3,4-Thiadiazoles Substituted with Oxazepine and Benzoxazepine Moieties
... and 4-hydroxybenzaldehyde as coupling reagents to give azo derivatives 4a and 4b containing aldehyde group, ...synthesized thiadiazoles have some biological, pharmaceutical and medicinal ...
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Synthesis, characterization and antimicrobial activities of imidazo [2,1,b][1,3,4] thiadiazoles
... The increasing clinical importance of drug-resistant bacterial pathogens has lent additional urgency to microbiological and antibacterial research. Derivatives of [1,3,4]-thiadiazoles are known to exhibit ...
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Effect of Silk Strength by Dietary Supplementation of Silk Worm with 1,3,4 Thiadiazoles, In Silico and In Vitro Bombyx mori DNA Binding Studies
... All the reagents used are of AR grade. The Melting points were determined in open capillary tube. 1 H-NMR spectra were run on Brucker spectrometer (300 MHz) using Tetramethylsilane (DMSO) as solvent and Tetramethylsilane ...
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Synthesis of Some Novel 1,3,4-Thiadiazoles: Acid Catalyzed Cyclodehydration of Thiosemicabazides bearing Benzofuran and Pyrazole Moiety and their Antibacterial Screening
... Researchers always prefer to synthesize and characterize heterocyclic compounds because of their interesting pharmacological properties. Compounds containing benzofuran substituted at 2 and 3 positions have attracted ...
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Synthesis, charecterization and biological evaluation of some 1, 3 and 4 Thiadiazoles schiff bases
... present Thiadiazoles Schiffs bases were synthesized from Benzoic 1,3,4-thiadiazole derivative, the free position of the formed product was modified into various Schiffs bases by treating with different aromatic ...
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Antimicrobial Activity of Newly Synthesized Thiadiazoles, 5-benzyl-2 H tetrazole and Their Nucleosides
... The problem of multi-drug resistant microorganisms has reached on alarming level around the world and for the treatment of microbial infections; the synthesis of new anti-infectious compounds has become an urgent need. ...
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Thiadiazoles: Progress Report on Biological Activities
... A number of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were synthesized and evaluated for their antiproliferative activity by Matysiak et al [17]. The panel substitution included alkyl, aryl ...
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SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL SUSTITUTED [1,2,4]TRIAZOLO[5,1 b][1,3,4]THIADIAZOLE DERIVATIVES
... The search for potent bioactive agents in pharmaceutical industry has been directed towards the nitrogen containing heterocycles. In recent days the researchers think about synthesis of bridged derivatives of nitrogen ...
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