43 kDa
Interdomain interactions of the transactive response DNA binding protein 43 kDa (TDP-43)
... in many other proteins (reviewed in 109). Upon release of the C-terminal domain interaction by RNA-binding or post-translational modification, for example, the NES would be exposed and export of TDP-43 could ...
136
Regulation of the biosynthesis of subgroup C adenovirus protein IVa2.
... Protein IVa2 A to E and the 43-kDa protein F were visualized with IgGs affinity purified against the 54-kDa viral and 43-kDa cellular proteins, respectively, as described in Materials an[r] ...
10
Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins
... protein 43-kDa (TDP-43), pathologically associated to ALS and fronto- temporal lobar degeneration with ubiquitinated inclusions (FTLD-U) [22] that was also shown to be sequestered in polyQ aggregates ...
20
Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy
... Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disease. To date, there is no any effective pharmacological treatment for improving patients’ symptoms and quality of life. Rapidly emerging ...
10
Review Article TDP-43 in aging and Alzheimer’s disease – a review
... of 43 kDa (TDP-43), an RNA and DNA binding protein involved in transcriptional repression, RNA splicing and RNA metabolism during the stress response, is the major component of neuronal inclusions in ...
9
Long-circulating delivery of bioactive polysaccharide from radix ophiopogonis by PEGylation
... ($20 kDa) together with a greater than 1 molar ratio of ROP to mPEG in reaction, long-circulating PEGylated ROPs, with PEG-grafting degree of ∼ ...exceeding 43 kDa, the conjugates prepared in this ...
8
Disease-modifying effects of metabolic perturbations in ALS/FTLD
... Like many neurodegenerative diseases, ALS and FTLD are associated with the abnormal aggregation of specific proteins in neurons and glia. Superoxide dismutase 1 (SOD1) was the first aggregated protein to be associated ...
16
Characterization of Chlamydia pneumoniae species specific proteins immunodominant in humans
... pneumoniae, a 40-kDa major outer membrane protein was genus specific and 53-, 46-, and 43-kDa proteins were species specific in their reactions with the majority of the human sera used..[r] ...
6
Cellular locations of proteinases and association with vesicles in porphyromonas gingivalis
... we noticed that RGP and KGP are found in the culture supernatant, in the surfaces and within the cy- toplasm. as for those in the culture supernatant, two types of enzymes exist: one is a free form and the oth- er is ...
6
Different biological activities of the hetero- and homodimers formed by the 47- and 43-kilodalton proteins of transcription factor ATF/E4TF3.
... Binding reaction mixtures containing 0.5 ,ul of the renatured 43-kDa protein alone lanes 1 to 4, 0.5 ,ul of a mixture of the renatured 43- and 47-kDa proteins lanes S to 8, 0.5 ,ul of th[r] ...
8
AQP4 isoforms, and among them AQP4 isoforms containing exon 2 constituted approximately 38%. The
... in the ovine CP (Figure 3a). However, blocking of antibodies did not completely abolish the signal of 23 kDa, what may result from an insufficient amount of blocking peptide used. The relative abundance of these ...
11
Expression of the 60 kDa and 71 kDa heat shock proteins and presence of antibodies against the 71 kDa heat shock protein in pediatric patients with immune thrombocytopenic purpura
... Methods: Using western blot, we measured the levels of the 60 kDa heat shock protein (Hsp60) and of the inducible 71 kDa member of the Hsp70 family (Hsp71) in lymphocytes and the presen[r] ...
10
Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration
... 40-60 kDa range, with higher and lower molecular weight regions accounting for the remainder of the ~4-fold change in these ...49 kDa corresponding to the full length protein, we detected 3 specific SEPT11- ...
13
Epstein-Barr Virus-Encoded RK-BARF0 Protein Expression
... While these data demonstrate that the 30- to 35-kDa mem- brane-associated proteins do not represent RK-BARF0, they do not exclude the existence of the RK-BARF0 gene product in EBV-positive cells. Thus far the best ...
5
The origin of plasma neutrophil gelatinase-associated lipocalin in cardiac surgery
... However, several potential limitaitions call for atten- tion. First, these results cannot be directly generalised to other clinical conditions with elevated NGAL, i.e. sepsis and renal transplantation. Because CPB ...
10
Molecular Weight Determination of a Protease Extracted from Mucor pusillus: Comparison Methods
... The results obtained with the different techniques for evaluating the molecular weight of the protease confirm the use of chromatographic methods. The electrophoretic profile shows that the active fraction appears one ...
7
Regulation of platelet-activating factor-mediated interleukin-6 promoter activation by the 48 kDa but not the 45 kDa isoform of protein tyrosine phosphatase non-receptor type 2
... 48 kDa PTPN2 modulates Akt activation via a PKD‑dependent ...48 kDa or 45 kDa PTPN2 constructs tagged with FLAG, PKD tagged with GST or control vectors (pcDNA3 or ...48 kDa PTPN2 or PKD ...
22
Acclimation of the threshold induction temperatures for 70 kDa and 90 kDa heat shock proteins in the fish Gillichthys mirabilis
... Some tissues showed enhanced HSP synthesis when the exposure temperature equalled the acclimation temperature: HSP70 was synthesized in gill and liver tissue of control fish acclimated a[r] ...
6
Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii
... 54 kDa serine protease that cleaves these toxins ...50–60 kDa were subjected to BLASTp against the MEROPS database and of these, 221 hits were ...50–60 kDa and were the same proteins identified by ...
8
Activation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the Mutation
... Endoplasmic reticulum (ER) stress and autoph- agy are two critical players in the pathogenesis of ALS [17-21] and both have been recently correlated with TDP-43 proteinopathy [22-27]. ER is a vital cellular ...
10