4E-BP1
Expression of 4E-BP1 and phospho-4E-BP1 correlates with the prognosis of patients with clear cell renal carcinoma
... Paraffin blocks that contained sufficient formalin-fixed tumor specimens were serial sectioned at 3 μm and mounted on silane-coated slides for immunohistochemical staining analysis. Dimethylbenzene rehydrated through ...
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eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer
... overexpressed 4E-BP1 in Panc-1, which express low endogenous levels of 4E-BP1 protein (18, ...of 4E-BP1 reduced the amount of RRM2 and CDC6 under similar treatment (Supplemental ...
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RPPA-based protein profiling reveals eIF4G overexpression and 4E-BP1 serine 65 phosphorylation as molecular events that correspond with a pro-survival phenotype in chronic lymphocytic leukemia
... Though several proteins have individually been investigated when determining the oncogenic features of CLL, no current study has simultaneously examined numerous protein alterations on a comprehensive level. Based on ...
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Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E BP1 translation regulator
... factor 4E–binding protein 1 (4E-BP1) hyperphosphorylation, resulting in dysregulated cap-dependent ...sT–associated 4E-BP1 serine 65 hyperphosphorylation was resistant to mTOR complex ...
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Muscle specific 4E BP1 signaling activation improves metabolic parameters during aging and obesity
... enhanced 4E-BP1 func- tion and (b) both mutants have elevated FOXO1 ...of 4E-BP1 in mouse skeletal mus- cle results in atrophic muscle and attenuates physical performance, while maintaining ...
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MTORC1 regulates cardiac function and myocyte survival through 4E BP1 inhibition in mice
... lated 4E-BP1 in cardiomyocytes promotes ...hypophosphorylated 4E-BP1 accumulates in Mtor-cKO myocar- dium and apoptosis is reduced when Mtor- cKO mice are crossed with mice lacking Eif4ebp1, ...
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AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis
... of 4E-BP1 on Thr37/ Thr46 also rebounded between 8 and 24 h after treatment with mTORKIs such as AZD8055 and ...of 4E-BP1 phosphorylation than mTORKIs alone and dramatically induces apoptosis ...
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MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling
... of 4E-BP1 following viral in- fections, there was no clear pattern in the activation of p70S6K at T389 after 24h infection ...between 4E-BP1 and p70S6K axis and type I IFN ...
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Deregulation of eIF4E: 4E-BP1 in Differentiated Human Papillomavirus-Containing Cells Leads to High Levels of Expression of the E7 Oncoprotein
... Viruses often use host DNA replication machinery to repli- cate viral DNAs, cellular transcription machinery to transcribe viral mRNAs, and cellular translation machinery to ensure translation of the viral mRNA. ...
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Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism
... eIF-4E BP1, an inhibitor of eIF-4E ...eIF-4E BP1 phosphorylation appear to be part of a “general” control re- sponse, inasmuch as they are elicited by depletion of virtually any single ...
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Vesicular Stomatitis Virus Infection Alters the eIF4F Translation Initiation Complex and Causes Dephosphorylation of the eIF4E Binding Protein 4E-BP1
... In summary, the data presented here show that VSV infec- tion results in changes in the eIF4F cap-binding complex that play a role in the inhibition of host protein synthesis but do not prevent viral protein synthesis, ...
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Twist1-mediated 4E-BP1 regulation through mTOR in non-small cell lung cancer
... Studies have shown the clinical significance of Twist1 in NSCLC [14–17, 32, 33], suggesting a reduced survival in patients with Twist1 overexpression; however, the specific molecular mechanisms driven by Twist1 in NSCLC ...
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Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence
... Many of the mRNAs identified play crucial roles in cell growth, metastasis, angiogenesis, and cell survival. Undoubtedly, there are vastly more that remain to be identified. The mRNAs regulated by eIF4E are considered ...
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Elevated sensitivity to diet induced obesity and insulin resistance in mice lacking 4E BP1 and 4E BP2
... Increased obesity and insulin resistance in 4E-BP1 and 4E-BP2 DKO mice. (A) Weight of the heart, gonadal (GWAT), retroperitoneal (RWAT), and inguinal (IWAT) white adipose tissue (n = 7–10) of WT and ...
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PC-1/PrLZ confers resistance to rapamycin in prostate cancer cells through increased 4E-BP1 stability
... overexpress 4E-BP1 as well [7–9] total and phosphorylated 4E-BP1 (p-4E-BP1) which is highly expressed in high-grade prostatic intraepithelial neoplasia (HGPIN) may help identify ...
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<p>4E-BP1<sup>Thr46</sup> Phosphorylation Association with Poor Prognosis in Quantitative Phosphoproteomics of Portal Vein Tumor Thrombus Revealed that 4E-BP1Thr46 Phosphorylation is Associated with Poor Prognosis in HCC</p>
... factor 4E-binding pro- tein 1 (4E-BP1) is a member of the translation inhibitor family, and also a substrate of the target of rapamycin signaling ...of 4E-BP1 was located in the ...
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Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease
... phosphorylate 4E-BP1 at the site Threonine (T) 37/T46 both in vivo and in vitro, leading to subsequent hyperphosphorylation of 4E-BP1 at T70 and S65 by LRRK2 or other protein kinases ...of ...
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HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution
... factor 4E binding protein 1; GBA1 glucocerebrosidase 1: glucosidase, beta, acid; GPNMB: glycoprotein (transmembrane) nmb; GSEA: gene-set enrichment analysis; HEPES: 4-(2-hydroxyethyl)-1- piperazineethanesulfonic ...
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Upregulated TRIM29 promotes proliferation and metastasis of nasopharyngeal carcinoma via PTEN/AKT/mTOR signal pathway
... To reveal the potential mechanisms underlying the aggressiveness promoting role of TRIM29 in NPC cells, the effect of TRIM29 expression on Akt/mTOR signal pathway were explored. It was reported that activated Akt/mTOR ...
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The physiological and molecular response to repeated sprints in male and female team sport athletes : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Sport and Exercise Science at Massey University, Palmerston North, New Zealand
... factor 4E binding protein 1 (4E-BP1) are important regulators of mRNA initiation and elongation and hence affect protein synthesis and cell ...
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