4T1 cells
Silencing of Atp6v1c1 Prevents Breast Cancer Growth and Bone Metastasis
... of 4T1 or 4T1-LacZ tumor bearing mice has thinner cortical bone and globular intumescences (red arrows), while there was no significant change visible in the bone of the PBS control, 4T1-c1s3-1 and ...
10
Targeting specificity of dendritic cells on breast cancer stem cells: in vitro and in vivo evaluations
... verapamil-resistant 4T1 cells was evaluated by assays including mammosphere culture, ALDH expres- sion, and in vivo ...-untreated 4T1 cells were placed in culture flasks in serum-free ...
12
Palm Tocotrienol-Adjuvanted Dendritic Cells Decrease Expression of the SATB1 Gene in Murine Breast Cancer Cells and Tissues
... Tocotrienol-rich fraction (TRF) is the vitamin E fraction extracted from palm oil, which contains 70% mixed tocotrienols and 30% alpha-tocopherol [22,23]. Tocotrienols and tocopherols are fat-soluble vitamins related to ...
17
Focused ultrasound-augmented targeting delivery of nanosonosensitizers from homogenous exosomes for enhanced sonodynamic cancer therapy
... target cells via endocytosis and membrane fusion has been extensively studied, the potential mechanism of EXO-DVDMS uptake under US stimulation is more complex ...of 4T1 cells with high FD500 ...
21
Chemotherapeutic activity of Silymarin combined with doxorubicin liposomes in 4T1 breast cancer cells
... Figure 3 Combination indexes (CIs) of DXL and SLM mixture at the different DXL concentrations in 4T1 cells. Plates were seeded with 2500 4T1 cells/well. After an overnight incubation, the ...
6
Diversity of matriptase expression level and function in breast cancer
... MDA-MB-231 cells had no visible effects on cellular morphology ...in 4T1 cells at a level comparable to that observed in human breast cancer cell lines ...from cells transfected with the ...
11
Gallotannin rich Caesalpinia spinosa fraction decreases the primary tumor and factors associated with poor prognosis in a murine breast cancer model
... detection 4T1 cells (1 × 10 4 ) suspended in 100 μL of saline phosphate-buffer were injected into the right mammary fat pad (subcutaneously [SC]) on day ...
13
Intracellular “activated” two-photon photodynamic therapy by fluorescent conveyor and photosensitizer co-encapsulating pH-responsive micelles against breast cancer
... M, 4T1 cells were incubated with PL TPA M ...the cells were incubated at 37 ° C (5% CO 2 ) for 3 ...live cells was monitored for 30 min after PL TPA M was added to the culture ...the ...
13
Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation
... levels. 4T1 cells transduced with WT or Src-resistant Y289F PDHA1 were treated with DCA (10 mM), followed by ROS ...cancer cells, a significant portion of glucose carbon is diverted to biosynthetic ...
12
Attenuated mutant strain of Salmonella Typhimurium lacking the ZnuABC transporter contrasts tumor growth promoting anti- cancer immune response
... adenocarcinoma 4T1 cells, as seen by a 40% reduction of viable cells in culture as compared to untreated cells (Figure 1A and ...immune cells in both spleens and tumor ...B ...
13
A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer
... metastatic 4T1 breast cancer cells, which effectively confirms the superior inhibitory effects on cell migration and invasion activities, VCAM-1 expression and cell-cell binding of RAW ...
11
Neuroprotective Effect of 4T1 and Sertoli Cells CoTransplantation in Animal Model of Brain Ischemia
... Cancer cells such as 4T1 (an invasive breast carcinoma cell line) are the most potent cells with high viability in transplanted ...The 4T1 cells are derived from spontaneous tumors in ...
7
Ultra-small Pyropheophorbide-a Nanodots for Near-infrared Fluorescence/Photoacoustic Imaging-guided Photodynamic Therapy
... The cells maintained full viability when they were treated with Pa-PEG nanodots up to 20 μM for 24 h without irradiation (Figure ...the cells incubated with ...non-radiated cells remained alive ...
12
Tamoxifen Inhibits ER-negative Breast Cancer Cell Invasion and Metastasis by Accelerating Twist1 Degradation
... HeLa cells transfected with pQCXIH-Luc or pQCXIH-Twist1-Luc plasmids and with a β-galactosidase expression plasmid were treated with vehicle (ethanol) or tamoxifen (10 μM) for 24 ...tamoxifen-treated ...
11
Interleukin like epithelial to mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen–urokinase plasminogen activator receptor system–regulated secretion during breast cancer progression
... AC developed the hypotheses and was a major contributor in designing and performing most of the experiments, analyzing the data and in writing the manuscript. BK participated in the design and carrying out of the ...
18
Lipocalin 2 promotes lung metastasis of murine breast cancer cells
... of 4T1 cells in BALB/c ...cancer cells growing in the complex cellular envi- ronment of the host ...epithelial cells in both inflammatory and neoplastic colorectal diseases ...
9
Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer
... using 4T1 cells, which closely mimic tumor growth and metastatic spread of stage IV human breast cancer in ...BALB/c. 4T1 cells were treated ex vivo for 14 days with Tat-SID, which resulted in ...
19
Tumor-specific activated photodynamic therapy with an oxidation-regulated strategy for enhancing anti-tumor efficacy
... in 4T1 cells by MTT assay. 4T1 cells supplemented with HA-GA@Ce6 and irradiated at 638 nm for 2 min exhibited significantly enhanced cytotoxicity when compared to HA-GA@Ce6 without irradiation ...
13
Arthritis augments breast cancer metastasis: role of mast cells and SCF/c Kit signaling
... tumor cells to migrate toward the MCs in an in vitro migration ...GFP-positive 4T1 cells in the lungs of SKG mice injected with 4T1 cells with no treat- ment versus the treated ...
20
Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1
... MDA-MB-231 cells were grown adherently and maintained in DMEM (Gibco) containing 10% fetal calf serum (FCS), 100 U/ml penicillin and 100 μg/ml ...carcinoma 4T1 and 4T1-luc2 (i.e., 4T1 ...
25