5-AZA-CdR
Epigenetic Inheritance of 5-AZA-2'-Deoxycytidine (5-AZA-CdR) Induced Alterations
... 67 rats demasculinizes and feminizes male offspring due to its antiandrogenic activity [36]. The effects of Di-n-butyl phthalate (DBP) on male reproductive tract development include missing epididymis and vasa ...
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RUNX3 gene promoter demethylation by 5-Aza-CdR induces apoptosis in breast cancer MCF-7 cell line
... of 5-aza-2′-deoxycytidine (5-Aza-CdR) on cell proliferation and apoptosis by demethylation of the promoter region and restoring the expression of RUNX3 in the breast cancer MCF-7 cell ...
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Original Article 5-Aza-CdR can reverse gefitinib resistance caused by DAPK gene promoter methylation in lung adenocarcinoma cells
... The 5-Aza-CdR make human gastric cancer cell lines, bladder cancer, cervi- cal cancer and other methylated genes DAPK removing methylation, re-expression or upregu- lation, meanwhile, it can ...
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<p>5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And Apoptosis</p>
... HCT116+5- Aza-CdR group, SW480 group, SW480+5-Aza-CdR group, SW620 group and SW620+5- Aza according to experimental ...group, 5-Aza-CdR+HCT116 ...
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Downregulation of long noncoding RNA MEG3 is associated with poor prognosis and promoter hypermethylation in cervical cancer
... Methods: ROC curve and Cox regression analyses were used to assess the diagnostic and prognostic value of MEG3 in patients with cervical cancer. The methylation status of the MEG3 promoter in cervical cancer tissue ...
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Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy
... dose-schedule 5-AZA- ...dose 5-AZA-CdR; b) the target cancer cells may have a low level of deoxycytidine kinase, the enzyme that activates the prodrug, 5-AZA-CdR ...
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The Effect of 5-Aza-2′-Deoxycytidine in Combination to and in Comparison with Vorinostat on DNA Methyltransferases, Histone Deacetylase 1, Glutathione S-Transferase 1 and Suppressor of Cytokine Signaling 1 Genes Expression, Cell Growth Inhibition and Apop
... of 5- AZA-CdR and SAHA (individually and combined) on GSTP1 and SOCS1 gene expression as a mechanism of apoptosis ...of 5-AZA-CdR on GSTP1 and SOCS1 re- activation is one of the ...
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AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine
... analogue 5-aza- CR (5-azacytidine) was initially identified as a potential anticancer drug and was subsequently shown to be a DNA methyltransferase (DNMT) inhibitor ...DNA, 5-aza-CR is ...
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Molecular control of HIV 1 postintegration latency: implications for the development of new therapeutic strategies
... 5-Aza: 5-azacytidine; 5-Aza-CdR: 5-aza-2'-deoxycytidine; AP-1: Activating Protein-1; APOBEC3G: APOlipoprotein BmRNA Editing Catalytic subunit-like protein 3G; ...
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DNMT and HDAC inhibitors modulate MMP-9-dependent H3 N-terminal tail proteolysis and osteoclastogenesis
... of 5-Aza-CdR treat- ment on MMP-9 expression and H3NT proteolysis, we also wanted to study how 5-Aza-CdR treatment affects DNA methylation levels of MMP-9 ...or ...
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Original Article Role of Syk gene promoter demethylation in the biological behavior of medulloblastoma
... Abstract: Purpose: To investigate the demethylation status of the Syk gene promoter in human medulloblastoma cell lines and the interrelationship with biological behavior of medulloblastoma. Methods: D341 and Daoy cells ...
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Hypermethylation of MEG3 promoter correlates with inactivation of MEG3 and poor prognosis in patients with retinoblastoma
... tor 5-Aza-CdR could restrain the methylation of MEG3 ...the 5-Aza-CdR on MEG3 expres- ...with 5-Aza-CdR and the incre- ment was positive relation to the ...
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The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry
... either 5-AZA-CdR [22] or the second-generation DNMT inhibitor guadecitabine [23] significantly reduced the growth of poorly immunogenic syngeneic grafts of murine mammary carcinoma TS/A and of ...
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Original Article Investigating RASSF1A hypermethylation and endometrial carcinoma occurrence and development using in vivo and in vitro demethylation of 5-AZA-2’-deoxy cytidine
... of 5-AZA-2’-deoxy cytidine ...tissues. 5-Aza-CdR application reversed the abnormal RASSF1A hypermethylation, inhibited transplanted tumor growth, and induced apoptosis in a ...
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Effect of 5-aza-2′-deoxycytidine on p16INK4a, p14ARF, p15INK4b Genes Expression, Cell Viability, and Apoptosis in PLC/PRF5 and MIA Paca-2 Cell Lines
... decitabine, 5- aza-2′-deoxycytidine (5-aza-CdR), and ...and 5-aza-CdR has been achieved in both solid and hematological ...agent 5-aza-CdR can ...
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Methylation status of insulin-like growth factor-binding protein 7 concurs with the malignance of oral tongue cancer
... as 5-aza-2′-deoxycytidine (5′AZA), which is also chose to test its effect in the present ...with 5′AZA can inhibit IGFBP-7 promoter methylation and renovate the expression of ...
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Generation of tumor initiating cells by exogenous delivery of OCT4transcription factor
... three-dimensional; 5-aza-2 ’ dC: 5-aza-2 ’ -deoxycytidine; CDH1: E-cadherin; CK: cytokeratin; CTG: Cell Titer Glo; DMEM: Dulbecco ’ s modified Eagle ’ s medium; EMT: epithelial-to-mesenchymal ...
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Hypomethylation and aberrant expression of the glioma pathogenesis related 1 gene in Wilms tumors
... Our methylation analysis of GLIPR1/RTVP-1 reveals re- markably frequent tumor-specific hypomethylation of the gene, apparent in 87.5% of WTs (n = 24). By way of comparison, R- RAS analysis showed partial hypomethylation ...
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Circulating cell free DNA based epigenetic assay can detect early breast cancer
... As the number of samples of FFPE tissue specimens was relatively small, we validated the methylation status of the candidate markers using relatively large public data- sets. There were 143 samples of PBMC in GSE 58888 ...
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Ovarian cancer plasticity and epigenomics in the acquisition of a stem-like phenotype
... inhibitors 5-aza-dC, decitabine and zebularine show promise in reversal of repressive histone mark pat- terns and resensitization of ovarian cancer cells to chemo- therapy [127,128], and several are ...
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