5-deiodinase
Dual mechanisms of regulation of type I iodothyronine 5' deiodinase in the rat kidney, liver, and thyroid gland Implications for the treatment of hyperthyroidism with radiographic contrast agents
... Alterations in thyroid hormone status and the administration of radiographic contrast agents can markedly influence iodothyronine metabolism and, in particular, the activity of type I 5'- deiodinase ...
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Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency
... iodothyronine 5'deiodinase (5'DI), one of two enzymes that metabolize thyroxine (T4) to 3,5,3'-triiodothyronine ...renal 5'DI mRNA in a high (C57BL/6J) and low (C3H/HeJ) strain paralleled ...
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Ontogenesis of iodothyronine 5' deiodinase Induction of 5' deiodinating activity by insulin, glucocorticoid, and thyroxine in cultured fetal mouse liver
... iodothyronine-5'- deiodinase in the fetal and neonatal period, fetal mouse liver of the 19th day of gestation, in which no iodothyronine-5'-deiodinating activity was detectable, was cultured in ...
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Iodothyronine 5' deiodinase in rat kidney microsomes Kinetic behavior at low substrate concentrations
... activities, with apparent Michaelis constants (Km) of 0.5 microM and 2.5 nM. Lineweaver- Burk plots of reaction velocities at nanomolar substrate concentrations in presence of 100 microM propylthiouracil also revealed an ...
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Somatostatin inhibits rat hepatic T4 5' deiodinase The effect is independent of the associated hypoinsulinemia
... +/- 5 pmol/min per 100 mg protein) and 72 h (90 +/- 7 pmol/min per 100 mg protein) was significantly reduced in the high-dose group (P less than ...T4-5'- deiodinase activity in the glucose-fed ...
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Potential of brown adipose tissue type II thyroxine 5' deiodinase as a local and systemic source of triiodothyronine in rats
... II 5'-deiodinase to generate T3 for the plasma pool. BAT 5'-deiodination (BAT 5'D) was stimulated by either short- (4 h) or long-term (7 wk) cold exposure (4 degrees ...
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Comparison of Iodothyronine 5′ Deiodinase and Other Thyroid Hormone dependent Enzyme Activities in the Cerebral Cortex of Hypothyroid Neonatal Rat: EVIDENCE FOR ADAPTATION TO HYPOTHYROIDISM
... 2, 5, and 20 mg methimazole (MMI) in 100 ml of the mothers' drinking water from day 16 of gestation throughout the nursing period and to the litters after ...I 5¢D, and, in some experiments, in vivo T 4 to ...
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Type II 5’Deiodinase Thr92Ala Polymorphism Is Associated with CVD Risk among Type 2 Diabetes Mellitus Patients
... riant in the DIO2 gene, which may have an implication in decreased phenotypic expression, but previous studies had conflicting outcomes. Consequently, we have undertaken this study to un- derstand the effect of this SNP ...
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Rapid alteration in circulating free thyroxine modulates pituitary type II 5' deiodinase and basal thyrotropin secretion in the rat
... thyrotroph would have a mechanism for modulating the production of T3, if T3 is, in fact, the sole bioactive signal providing negative feedback inhibition. To examine this apparent paradox, we administered EMD 21388, a ...
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Metabolic effect of 3,3',5' triiodothyronine in cultured growth hormone producing rat pituitary tumor cells Evidence for a unique mechanism of thyroid hormone action
... Physiologic levels of 3,3',5'-triiodothyronine (rT3) are generally believed to have minimal metabolic effects in the pituitary gland and other tissues. In the present studies, the regulatory role of rT3 and other ...
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Regulation of the Conversion of Thyroxine to Triiodothyronine in the Perfused Rat Liver
... physiologic functions of the liver. The perfused liver readily extracted T 4 from perfusion medium and converted it to T 3 . Production of T 3 by the perfused liver was a function of the size of the liver, the uptake of ...
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Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5' iodothyronine deiodinase in rat brown adipose tissue
... BAT 5'D but by a mechanism mediated through a long-lived messenger that correlates with growth ...BAT 5'D to increase abruptly after thyroidectomy as does the type II 5'-deiodinase in ...
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Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats
... iodothyronine 5'- deiodinase activity (5'D-I), reduces extrathyroidal T4 to T3 conversion by only 60-70% in euthyroid ...tissue. 5'D-II is insensitive to PTU ...
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Thyroid hormone deiiodinases
... Using these assays, 5'-deiodinase enzyme activities have been localized to the plasma membranes, to the endoplasmic reticulum and to the lysosomes prepared from liver and kidney homogena[r] ...
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Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain
... = 5–6) or suppressed serum TSH (Thr92-Dio2: ...(Figure 5, I and J, and Figure 6, I and ...(Figure 5, I and J, and Figure 6, I and ...(Figures 5, K and L, and Figure 6, K and ...
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Antibody mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters
... Second, we found that the effect of FGFR1c inhibition on caloric intake was greater in hamsters in the LD fat state when compared to those in the SD lean state, suggesting that activity of the FGFR1c system might vary as ...
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Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine
... response 5 (Ler5), MAM domain–containing proteoglycan (Mamdc2), myelin basic protein (Mbp), neurogranin (protein kinase C substrate) (Rc3), neurotrophin-3 (Nt3), potassium inwardly rectifying channel (Kcnj10), Ras ...
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Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism—protocol for a systematic review
... and deiodinase genes in Web of Science database showed a large variation in the study design used in articles, and the articles consist mainly of non- randomised studies ...
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Two patients with atypical low triiodothyronine syndrome: primary deiodinase abnormalities?
... suggests that the alterations in circulating thyroid hormone levels were not secondary, but might represent primary abnormalities in deiodinase activity. In support of this speculation, Peeters et al. (15) have ...
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Thyroid hormones and their placental deiodination in normal and pre eclamptic pregnancy
... expression or activity of either deiodinase enzyme and maternal or fetal serum selenium... We have shown the presence of mRNA and protein D3 in term placenta, which is in.[r] ...
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