5-FU
Measurements of 5 FU Plasma Concentrations in Patients with Gastrointestinal Cancer: 5 FU Levels Reflect the 5 FU Dose Applied
... Introduction: 5-Fluorouracil (5-FU) is the basis of most combination chemotherapies for gastrointestinal ...the 5-FU component of the chemotherapy-combination, ...of 5-FU ...
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Original Article Effects of DPYD and TS gene polymorphisms on chemosensitivity of 5-FU in advanced colorectal cancer
... With the development of the Human Genome Project (HGP) research, researchers have ob- tained more understanding of gene polymor- phisms. It was found that gene polymorphisms change protein expression levels. This, in ...
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Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU
... antimetabolite 5-FU in colorectal cancer ...to 5-FU. These results indicate that BCL6B sensitizes HCC cell to 5-FU by activating p53 ...
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GRP78 confers the resistance to 5-FU by activating the c-Src/ LSF/TS Axis in hepatocellular carcinoma
... treatment and confines its use in clinical practice [9-11]. Many signaling pathways have been demonstrated to contribute to the resistance to 5-FU [12, 13]. Among them, the LSF/TS axis plays a decisive role ...
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A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5 FU treatment
... of 5 × 10 6 cells/well in 6-well dishes, and cultured for 24 ...analogue 5-FU (40 μM) (Sigma-Aldrich, ...for 5 h at ...with 5 μ g/ml PI for 1 h at room ...
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Original Article SREBP1 promotes 5-FU resistance in colorectal cancer cells by inhibiting the expression of caspase7
... Using clinical samples, we found that the expression of SREBP1 in colon cancer tissues was significantly higher than that in normal tis- sues. Further experiments found that SREBP1 over-expression can inhibit ...
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Original Article Silencing of VMP1 makes breast cancer cells more aggressive and resistant to 5-Fu
... In summary, the present study first indicated the expression of VMP1 was negative related with the prognosis of breast cancer by analyz- ing the clinical samples and different cell lines. After gene silencing with ...
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Original Article MiR-106a-5p promotes 5-FU resistance and the metastasis of colorectal cancer by targeting TGFβR2
... deaths. 5-Fluorouracil (5-FU)-based chemotherapy has always been the first-line ...of 5-FU resistance seriously affects its curative ...of 5-FU resis- tance through ...
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Synthesis of liver-targeting dual-ligand modified GCGA/5-FU nanoparticles and their characteristics in vitro and in vivo
... between 5-FU and polymers, and the drugs retained in the outer layer are then rapidly dissociated and ...materials. 5) The final stage, the slow release phase (6–10 days, with a cumulative release ...
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miR-206 regulates 5-FU resistance by targeting Bcl-2 in colon cancer cells
... Notes: (A) hcT116/Fr and rKO/Fr cells were transfected with mir-206 mimic or mimic-nc for 24 hours. relative mir-206 level was detected by real-time Pcr. (B) hcT116/Fr cells were transfected with mir-206 mimic or ...
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Autophagy Inhibitor (LY294002) and 5 fluorouracil (5 FU) Combination Based Nanoliposome for Enhanced Efficacy Against Esophageal Squamous Cell Carcinoma
... study, 5-fluorouracil (5-FU) and LY294002 (LY)-loaded PEGylated nanoliposome was prepared to target esophageal squamous cell carcinoma ...from 5-FU and LY-loaded PEGylated nanoliposome ...
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c-Myc is regulated by HIF-2α in chronic hypoxia and influences sensitivity to 5-FU in colon cancer
... and 5-flurouracil (5-FU) ...to 5-FU. In contrast, knockdown of c-Myc impaired 5-FU chemosensitivity in colon cancer ...to 5-FU treatment in this ...
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Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles
... with 5-fluorouracil (5-FU) is mainly limited due to ...upon 5-FU treatment leads to the activation of ribosome- free rpL3 (L3) as proapoptotic ...of 5-FU plus plasmid ...
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Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer
... The expression level of proteins in GCAFs and cancer cells were examined as follows. Total cellular proteins were prepared from cell lysates with lysis buffer. As for apoptosis-related proteins detection, cells were ...
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5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53
... by 5-fluorouracil (5-FU) in colon cancer cells devoid of p53 leads to the activation of ribosomal protein L3 (rpL3) as proapoptotic ...of 5-FU-mediated inhibition of cell migration and ...
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Original Article CCND1 as an unfavorable factor mediated miR-340 suppression of chemotherapy resistance for 5-Fu in colon adenocarcinoma
... miR-340 had been demonstrated as a tumor suppressor in tumors [29, 30]. However, its role in regulating chemotherapy resistance of 5-Fu was still undetermined in colon cancer. In this study, miR-340 was ...
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PAK6 increase chemoresistance and is a prognostic marker for stage II and III colon cancer patients undergoing 5-FU based chemotherapy
... [4, 5, ...with 5-FU-based chemotherapy after radical ...predict 5-FU- susceptibility in patients with stage II and stage III colon ...
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Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU.
... Survivin is another anti-apoptosis gene that promotes cell proliferation and inhibits apoptosis. Although expressed at low levels in normal adult thymus and testis, survivin is highly upregulated in solid malignant ...
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Fucoxanthin enhances 5-FU chemotherapeutic efficacy in colorectal cancer cells by affecting MMP-9 invasive proteins
... of 5-FU eventually occurred in the advanced stage (III, IV) of colorectal cancer and it could be identified that some patients are intrinsically resistant to 5-FU, which is characterized by ...
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AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy
... with 5-FU treatment in Her-2 overexpression gastric cancer in vivo, indicating that AT101 is able to enhance 5-FU in the shrinkage of xenograft mice tumor and induction of cell ...
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