5-Triphosphate
Anti-angiogenic efficacy of 5′-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs
... forward 5′-AUGUGAAUGCAGACCAAAGAA-3′ and reverse ...forward 5′-UUCUCCGAACGUGUCACGU-3′ and reverse ...matching 5′-triphosphate-modified siRNA was transcribed using the correlating DNA template ...
11
Role of Inositol 1, 4, 5-Triphosphate on Heart Rate in Isolated Heart Models of Wistar Rats
... (Hyperpolarization-activated cyclic nucleotide-gated) channels which produces an inward current called the funny currents. This produces little depolarization of the membrane. At around -50 mV the T-type calcium channels ...
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Photoexcitation of Adenosine 5'-Triphosphate Anions in Vacuo : Probing the Influence of Charge State on the UV Photophysics of Adenine
... We report the first UV laser photodissociation spectra (4.0*5.8 eV) of gas*phase deprotonated adenosine 5'*triphosphate, diphosphate and monophosphate anions. The photodepletion spectra of these anions ...
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Small elevations of glucose concentration redirect and amplify the synthesis of guanosine 5' triphosphate in rat islets
... guanosine 5'-triphosphate (GTP) in insulin release, based on the use of GTP synthesis inhibitors (such as myocophenolic acid) acting at inosine monophosphate (IMP) dehydrogenase; herein, we examine the ...
12
Oral adenosine-5’-triphosphate (ATP) administration increases blood flow following exercise in animals and humans
... peripheral blood flow, and blood oxygenation [10,14] and human studies have resulted in significant improve- ments in body composition and performance [4,6]. Studies on the oral availability of ATP showed that it is ...
7
Effect of adenosine 5'-triphosphate and magnesium ions on citrate synthase.
... by 5*-AMP and 3'»5'- cyclic AMP, appears to rule out the direct participation of the purine residue in the observed inhibition of CS, Accordingly, experiments were carried out to see whether inorganic ...
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Evaluation of an adenosine 5' triphosphate assay as a screening method to detect significant bacteriuria
... There was 89.4% agreement between the culture method and the ATP assay, with 7.0% false positive and 27.0% false negative results from the ATP assay using 105 organisms/ml of urine or gr[r] ...
5
Neuroprotection mediated by changes in the endothelial actin cytoskeleton
... cerebral artery (MCA) occlusion. We report that disruption of Rho-mediated endothelial actin cytoskeleton leads to the upregulation of eNOS expression and reduces the severity of cerebral ischemia following MCA ...
11
Targeting cancer cell metabolism in pancreatic adenocarcinoma
... adenosine 5’-diphosphate; ATP, adenosine 5’-triphosphate; AA, amino acid; ASNS, asparagine synthetase; BCAA, branched-chain amino acid; CA, carbonic anhydrase; EGFR, epidermal growth factor receptor; ...
16
Uracil within DNA: an actor of antiviral immunity
... Uracil is a natural base of RNA but may appear in DNA through two different pathways including cytosine deamination or misincorporation of deoxyuridine 5'-triphosphate nucleotide (dUTP) during DNA ...
12
Crosstalk between purinergic receptors and lipid mediators in leishmaniasis
... Macrophages and neutrophils possess several pattern recognition receptors (PRR) that respond to pathogen- associated molecular patterns (PAMPs) present in the Leishmania surface, such as lipophosphoglycan (LPG) and ...
9
The quest for modernisation of traditional Chinese medicine
... Abbreviations APL: Acute promyelocytic leukaemia; ATP: Adenosine-5’-triphosphate; EMA: The European Medicines Agency; EU: European Union; FDA: The Food and Drug Administration of the Uni[r] ...
11
Magnetic nanoformulation of azidothymidine 5’-triphosphate for targeted delivery across the blood–brain barrier
... azidothymidine 5’-triphosphate (AZTTP) liposomal nanoformula- tion and its ability to transmigrate across an in vitro BBB model by application of an external magnetic ...
10
METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF EMTRICITABINE, TENOFOVIR AF, DOLUTEGRAVIR IN ITS BULK AND PHARMACEUTICAL DOSAGE FORM BY RP-HPLC METHOD
... Emtricitabine 5'-triphosphate, which is responsible for the inhibition of HIV-1 reverse ...deoxycytidine 5'-triphosphate and incorporates into nascent viral DNA, resulting in early chain ...
8
Treatment with Oral ATP decreases alternating hemiplegia of childhood with de novo ATP1A3 Mutation
... Results: With the dosage of adenosine-5'-triphosphate administration increased, the patient showed significantly less frequency and shorter duration of hemiplegic episodes. Treatment with ...
5
Skinned fibres produce the same power and force as intact fibre bundles from muscle of wild rabbits
... Thin fibre bundles (4 – 5 mm in diameter) were permeabilised on ice in solution A (Table 2) containing 2% Triton X-100. For fibres from 10 of the 16 rabbits, this solution also contained 20 mmol l −1 BDM ...
8
Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase
... We were unable to solve the LmMK structure by molecular replacement and therefore adopted a single wavelength anomalous dispersion approach. Data to 2.0 Å identified six Se positions out of eight (SOLVE[34]) and the ...
16
Characterisation of P glycoprotein 9 1 in Haemonchus contortus
... When the Hco-PGP-9.1 transport function was assessed, using the fluorophore probe Rho123, a pro- nounced reduction of this tracer dye in Hco-Pgp-9.1/ LLC-PK1 transfectants was determined, indicative of an active ...
11
Investigation of the MUC1-independent action of circulating galectins in metastasis promotion
... abnormally expressed. The mutation of oncogenes enables the cells to undergo uncontrollable proliferation and survive, avoiding programmed cell death (apoptosis) (5). The mutation of oncogenes can result from ...
261
Sex-specific expression during embryonic development of Anopheles gambiae
... cDNA fragmentation carried out during this experiment, as opposed to RNA fragmentation prior to cDNA synthesis, is known to induce a 3’ bias upon transcript mapping of oligo-dT primed cDNA (Wang et al. 2009). To ...
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