5-trisphosphate receptor
Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia
... We report on a serum autoantibody associated with cerebellar ataxia. Immunohistochemical studies of sera from four patients referred for autoantibody testing revealed binding of high-titer (up to 1:5,000) IgG antibodies, ...
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Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy
... 1,4,5-trisphosphate receptor, the main intracellular Ca 2+ -release channel, in apoptosis is well recognized, but its role in autophagy only recently emerged and is therefore much less well ...
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The synthesis and biological evaluation of d myo inositol 1,4,5 trisphosphate receptor ligands
... 3.50 mmol, 1 eq) in acetonitrile (50 mL) was added di-n-butyl tin oxide (0.96 g, 3.85 mmol, 1.1 eq), TBABr (1.13 g, 3.50 mmol, 1 eq) and benzyl bromide (1.79 g, 1.25 mL, 10.5 mmol, 3 eq). The mixture was heated under ...
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norpA and itpr mutants reveal roles for phospholipase C and inositol (1,4,5) trisphosphate receptor in Drosophila melanogaster renal function
... activate light-activated conductance (Raghu et al., 2000a). This response is, however, dependent on calcium entry via TRP/TRPL channels. DAG has been shown to activate native TRP and TRPL channels in photoreceptors and ...
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Three-dimensional structure of recombinant type 1 inositol 1,4,5-trisphosphate receptor.
... for 5 min and applied to a HiTrap Q FF anion-exchange column, which was then washed (100 ml, 1 ml/min) with ion-exchange medium (50 mM Tris/HCl, 150 mM NaCl, 1 mM EDTA, 1 mM dithiothreitol, 5 % glycerol and ...
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The redistribution of Ca2+ stores with inositol 1,4,5 trisphosphate receptor to the cleavage furrow in a microtubule dependent manner
... pAb against ER was a kind gift from Dr. Daniel Louvard in Institute Curie (Louvard et al., 1982). Rabbit polyclonal antibody to the ryanodine receptor (C2) was raised, as described (Kuwajima et al., 1992). Mouse ...
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Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy
... Case 1. A 60-year-old male heavy smoker (35 pack- years) with no significant neurological history developed severe weakness of the lower legs, which rapidly ascended within 1 week, involving first the thighs and hip ...
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Neuropathologic Role of Inositol (1,4,5)-Trisphosphate Receptor Proteolysis
... cardiac arrest targets early reperfusion and restoration of blood flow, as the severity of neurological injury depends on the duration of ischemia. Periods of ischemia that are sufficient to trigger depolarization of ...
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Enriched endoplasmic reticulum-mitochondria interactions result in mitochondrial dysfunction and apoptosis in oocytes from obese mice
... 1,4,5-trisphosphate receptor, type 1 (IP3R1), inositol 1,4,5-trisphosphate receptor, type 2 (IP3R2) and phosphofurin acidic cluster sorting protein 2 ...
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Genetic Dissection of itpr Gene Function Reveals a Vital Requirement in Aminergic Cells of Drosophila Larvae
... Signaling by the second messenger inositol 1,4,5-trisphosphate is thought to affect several developmental and physiological processes. Mutants in the inositol 1,4,5-trisphosphate receptor (itpr) gene ...
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Presynaptic Ca2+ stores contribute to odor induced responses in Drosophila olfactory receptor neurons
... dendrites of a few uniglomerular projection neurons (PNs), which propagate olfactory information to higher brain centers, such as the mushroom bodies. They also make contact with local interneurons (Stocker, 1994; Wilson ...
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A Hermeneutical Examination of Creation in Islam at Georgia State University
... A second pharmacophore model has recently been proposed using HipHop which is also part of the Catalyst software. 24 The difference between the two programs is that HipHop uses a much narrower scope and only looks as ...
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Regulation of inositol 1,4,5 trisphosphate receptors
... Xenopus receptor appears to be a species variant of the type 1 receptor, displaying 90% sequence homology with the mouse cerebellar type 1 receptor, whereas the Drosophila receptor differs ...
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Original Article Vagus nerve stimulation causes wake-promotion by affecting neurotransmitters via orexins pathway in traumatic brain injury induced comatose rats
... NMDAR1, 5-HT 2A R, H1R and α1-AR, and reduction of GABAbR in wake-pr- omotion of VNS, this conclusion is consistent with previous ...NMDAR1, 5-HT2AR, H1R and α1-AR and decreased expression of GABAbR in the ...
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Paroxysmal hypnogenic dyskinesia is associated with mutations in the PRRT2 gene
... expression of the PRRT2 mutation indicates that the PRRT2 genotype likely does not predict clinical phenotype. The underlying mechanism of phenotype variations should be examined in ways other than genotype of PRRT2 . ...
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Sequence and translation initiation properties of the xenopus TGFbeta5, PDGF A, and PDGF alpha receptor 5' untranslated regions
... PDGF-α receptor 5’UTRs were investigated. 5' extended cDNAs were obtained by 5’RACE, resulting in long 5’UTRs (478-710 nt) with multiple upstream AUGs (3-13), and the potential to fold ...
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Hypothesizing “Reward” Gene Polymorphisms May Predict High Rates of Injury and Addiction in the Workforce: A Nutrient and Electrotherapeutic Based Solution
... With regard to the reward circuitry it is very interesting that Young et al. [105] studied the relationship be- tween the GABA and dopamine gene systems. In this regard, there have been some significant identifications ...
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A Mini Review of Serotonin and Its Receptors
... S. 5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and ...by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic ...
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The folate receptor works in tandem with a probenecid sensitive carrier in MA104 cells in vitro
... membrane receptor for ...of 5- methyltetrahydrofolate through the membrane into the ...the receptor or the internalization of the vitamin-receptor complex, which suggests that passage is ...
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Regulation of ion channels by inositol trisphosphate and diacylglycerol
... In these permeabilized cells, the release of calcium from the endoplasmic reticulum by Ins 1,4,5P3 occurs fast enough for it to be able to stimulate various physiological processes such [r] ...
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