6-mercaptopurine
Simultaneous Analytical Method Development of 6-Mercaptopurine and 6-Methylmercaptopurine in Plasma by High Performance Liquid Chromatography-Photodiode Array
... First, 6-mercaptopurine will be transformed by hypoxanthine phosphoribosyl transferase (HPRT) into thioinosine mo- nophosphate (TIMP) and subsequently into 6-thioxanthosine-5-mono- phosphate (TXMP) ...
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Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system
... Using this viability (MTT) study, the newly synthesized FCMP and FCMP-D nanoparticles showed efficacy in the leukemia cell line in a dose-dependent manner, the pattern of which resembles that for MP (Figure 8A). On the ...
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Study of Electron Transfer Path on Reaction of Xanthine Oxidase with 6 Mercaptopurine and Hypoxanthine
... agent 6-MP have two alternate orientations in the active ...and 6-mercaptopurine, except that Thr 1010 appears to hydrogen bond to N1 or N7 (for the ...
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Meta-analysis of the impact of thioprine S-methyltransferase polymorphisms on the tolerable 6-mercaptopurine dose considering initial dose and ethnic difference
... 6-MP dose. The latest search was updated on January 20, 2016. The following keywords were employed: (leukemia) AND (TPMT OR thiopurine methyltransferase OR thiopu- rine s methyltransferase OR thiopurine ...
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Review Article Azathioprine/6-mercaptopurine versus 5-aminosalicylic for treatment of inflammatory bowel disease
... and 6-mercaptopurine (6-MP) in inflammatory bowel disease (IBD), and to conduct a meta-analysis of randomized controlled trials to compare the efficacy and safety of AZA/6-MP and 5-ASA in ...
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6-Mercaptopurine reduces cytokine and Muc5ac expression involving inhibition of NFκB activation in airway epithelial cells
... to 6-mercaptopurine (6-MP). As an immunosuppressive drug, 6-MP is widely used as a key agent in organ transplant recipients to prevent allograft rejection, as a maintenance drug for patients ...
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Inclusion Interaction Assembly Strategy for Constructing pH/Redox Responsive Micelles for Controlled Release of 6 Mercaptopurine
... drug 6-mercaptopurine and a hydrophilic β-CD grafted carboxymethyl chitosan were ...of 6-mercaptopurine showed a low release rate (about 27 wt% after 48 h) in pH ...of ...
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DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR ESTIMATION OF 6-MERCAPTOPURINE IN RABBIT PLASMA
... of 6-Mercaptopurine in plasma of ...analyse 6-Mercaptopurine in a single run and can be successfully applied for investigating the different pharmacokinetics parameters in rabbit as animal ...
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ANALYSIS OF 6 MERCAPTOPURINE AND 6 METHYLMERCAPTOPURINE IN DRIED BLOOD SPOTS USING LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY AND ITS APPLICATION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS
... of 6-MP and its metabolites in erythrocytes and plasma using high performance liquid chromatography (HPLC) and LC-MS/MS has been developed ...determine 6-MP in ...determining 6-MP and ...
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A new insight of structures, bonding and electronic properties for 6-mercaptopurine and Ag8 clusters configurations: a theoretical perspective
... [12]. 6-Mercaptopurine (6MP) has been utilized as the chemotherapy drug for many ...of 6-mercaptopurine (6MP) on a silver electrode in acid and alkaline medias via the SERS technique combined ...
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Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy
... conjugated 6-mercaptopurine (6MP) onto the surface of mercapto-modified mesoporous silica nanoparticles (MSNS) to form MSNS-6MP and loaded CDDP into the holes on the surface of MSNS-6MP to form ...
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6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation
... thine. 6-MP and its long-lived prodrug, azathioprine, are among the oldest pharmacological immunosuppressive agents in use ...today. 6-MP has been used for the treat- ment of acute childhood leukemia and ...
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Derivatives of 6-Mercaptopurine: Synthesis and Biological evaluation
... i.e. 6-mercaptopurine, 6-thioguanine, and azathioprine, have been considered as prominent molecular motif that are frequently encountered in drugs used for cancer chemotherapy ...
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SYNTHESIS OF NEW TWO DERIVATIVES OF 6 MERCAPTOPURINE (6MP) 6 [5 PYRIDINE 4 YL 1, 2, 3, 4 OXADIAZOLE 2 YL)DITHIOL] 9H PURINE (38) AND 9H PURINE 6 YL BENYLDITHIOCARBAMATE (45) WITH CYTOTOXICITY RESULTS FROM THE NATIONAL CANCER INSTITUTE’S ANTICANCER DRUG SCREEN
... Chemistry: The synthetic procedures for the designed target compounds 38 and 45 are illustrated in schemes (2) and (3) respectively. The starting material for the generation of target compound 38 was Isoniazid which was ...
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Promotion of SH SY5Y Cell Growth by Gold Nanoparticles Modified with 6 Mercaptopurine and a Neuron Penetrating Peptide
... with 6-mercaptopurine (6MP) and a neuron-penetrating peptide (RDP) as a neurophic agent to promote proliferation and neurite growth of human neuroblastoma (SH-SY5Y) ...
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Derivatives of 6-Mercaptopurine: Synthesis and Biological evaluation
... i.e. 6-mercaptopurine, 6-thioguanine, and azathioprine, have been considered as prominent molecular motif that are frequently encountered in drugs used for cancer chemotherapy ...
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Dietary polyphenols influence antimetabolite agents: methotrexate, 6 mercaptopurine and 5 fluorouracil in leukemia cell lines
... and 6-mercaptopurine in three out of four leukemia cell lines ...antagonized 6-mercaptopurine induced caspase 3 activity in both lymphoid cell lines and methotrexate induced caspase 3 activity ...
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Crystal structures of five 6 mercaptopurine derivatives
... with 6- mercaptopurine is the low bioavailability of the oral absorp- tion and the short half-life in ...of 6-mercaptopurine analogues that act as prodrugs or by the chemical protection of the ...
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THE EFFECTS OF 6 MERCAPTOPURINE ON HOMOGRAFT REACTIONS
... There were 4 groups of animals treated with 6-MP: A 9 animals were treated with 6 mg per kg per day for 2 weeks; B 7 animals were treated with 10 mg per kg per day for 2 weeks, then ever[r] ...
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Effect of 6 Mercaptopurine on Endotoxin Tolerance
... When the effluents from the first fractions were subjected to immunoelectrophoresis, the macroglobulin precipitin line was obvious only in the first fraction from the control animals but[r] ...
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