67-kDa laminin receptor
67 kDa laminin receptor increases cGMP to induce cancer selective apoptosis
... The 67-kDa laminin receptor (67LR) is a laminin-binding protein overexpressed in various types of cancer, including bile duct carcinoma, colorectal carcinoma, cervical cancer, and ...
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Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion
... 67 kDa laminin receptor (67LR) overexpression correlates with an enhanced invasive and metastatic potential in many human tumors [22–24] recommending the receptor as a new promising ...
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Leucht, Christoph (2003): The role of the 37-kDa/67-kDa laminin receptor in the cellular metabolism of the prion protein. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... 37 kDa LRP with different peptide fragments identified a transmembrane domain containing amino acids 86-101 (Castronovo et ...a laminin-binding domain comprising amino acids 161-180 (Castronovo et ...the ...
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Zuber, Chantal (2008): Antibodies directed against the 37 kDa/67 kDa laminin receptor as therapeutic tools for the treatment of prion diseases and cancer. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... active receptor-mediated event ...the laminin receptor were purified and overlay assays with recombinant PrP were performed ...the receptor were identified, including a 44 kDa, 60 ...
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Gauczynski, Sabine (2002): Characterization of the 37-kDa/67-kDa laminin receptor as the cell surface receptor for the cellular prion protein. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... The Semliki Forest virus (SFV) sytem was used to overexpress human wild-type and mutant prion proteins as well as FLAG-tagged human and bovine PrP in mammalian cells. The application of recombinant SFV vectors allowed a ...
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Rey, Clémence (2006): Single chain antibodies against the 37 kDa/67 kDa laminin receptor as tools for prion diseases therapy. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... To investigate the ability of the scFvs S18 and N3 expressed in E. coli to recognize denaturated LRP, we used them to probe Western Blots of cell lysate from BHK cells overexpressing human LRP::FLAG and murine LRP::FLAG, ...
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The 37/67-Kilodalton Laminin Receptor Is a Receptor for Adeno-Associated Virus Serotypes 8, 2, 3, and 9
... to 67% homologous to AAV8 and use sialic acids as receptors ...cellular laminin 1 with proteases and with the cell (1, ...a receptor for numerous viruses such as dengue virus and Sindbis virus, as ...
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Pflanz, Heike (2009): The 37kDa/67kDa Laminin Receptor LRP/LR as a molecular target in neurodegenerative diseases. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... 37 kDa/67 kDa LRP/LR on their cell ...the 67 kDa LR is expressed in the apical brush border of the small intestine and in the perinuclear region of Paneth cell secretory granules ...37 ...
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siRNA-mediated silencing of the 37/67-kDa high affinity laminin receptor in Hep3B cells induces apoptosis
... the 67-kDa laminin receptor (67LR), LAMR1, and the laminin-binding protein precursor p40 ...a 67-kDa protein through its high affinity interaction with laminin ...
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(−)-Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory cytokines in human cerebral microvascular endothelial cells
... 67-LR: 67-kDa laminin receptor; ANOVA: analysis of variance; BBB: blood – brain barrier; CNS: central nervous system; DMEM: Dulbecco ’ s modeified Eagle ’ s medium; EGCG: ( − ...
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Genomics, microRNA, epigenetics, and proteomics for future diagnosis, treatment and monitoring response in upper GI cancers
... 67LR: 67 kDa laminin receptor; A3B: apolipoprotein B mRA-editing enzyme, catalytic polypeptide-like 3B (=APOBEC3B); ACTN4: activator protein-1, alpha-actinin 4; AEG: adenocarci- noma of the ...
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Serotype-Specific Entry of Dengue Virus into Liver Cells: Identification of the 37-Kilodalton/67-Kilodalton High-Affinity Laminin Receptor as a Dengue Virus Serotype 1 Receptor
... anti-37/67-kDa laminin receptor antibody, 5 g of an anti-N-terminal GRP78 antibody, or 0 (control) 5, 10, or 20 g of soluble laminin prior to infection with dengue virus serotype 1 ...
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Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models
... 37-kDa laminin receptor (LR) precursor protein is highly conserved in ...heterodimeric 67-kDa dimeric forms that are present on eukaryotic cell membranes and interact with extracellular ...
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Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer
... immature laminin receptor protein (iLRP) [24, ...a 67-kDa dimeric acylated protein that associates with galectin-3 ...with laminin in basement membranes in their specialized function ...
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The Laminin Receptor Is a Cellular Attachment Receptor for Classical Swine Fever Virus
... at an MOI of 0.01. All three CSFV strains, the reporter virus CSFV- N pro Fluc, the CSFV Shimen strain, and the CSFV Tianjin/10 strain, shared a similar growth profile in cells with LamR knock- down (Fig. 2C to E). All ...
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Hundt, Christoph (2002): Interaction studies of the cellular prion protein. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... The laminin receptor family is highly conserved in a wide spectrum of eucaryotic cells (Keppel and Schaller, 1991; Wewer et ...37 kDa LRP acts as a receptor for the Venezuelan equine ...
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Synergetic downregulation of 67 kDa laminin receptor by the green tea (Camellia sinensis) secondary plant compound epigallocatechin gallate: a new gateway in metastasis prevention?
... As laminin is a major com- ponent of the basement membrane, it was shown that enhanced expression of 67LR promotes metastasis ...of laminin to 67LR. As a local consequence, laminin undergoes ...
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Role of the 39 kDa receptor associated protein (RAP) in Alzheimer's disease
... first lines of evidence for a function of sAPPβ came from a study in which sAPPβ production was increased in tropic-deprived condition, and sAPPβ was observed to undergo cleavage to produce a 35 kDa N-terminal ...
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Overexpression of β1 chain containing laminins in capillary basement membranes of human breast cancer and its metastases
... of laminin-9 and laminin-11 in normal vascular BMs to laminin-8 and laminin-10 (plus appearance of laminin-2) in the microvascular BMs of invasive ductal breast carcinomas and of their ...
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Murine laminin binds to Histoplasma capsulatum A possible mechanism of dissemination
... of laminin. A 50-kD H. capsulatum laminin-binding protein was demonstrated using an 125I-Ln blot of ...the 67-kD laminin receptor, suggesting they are ...to laminin, an important ...
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