786-O
Effect of Ku70 expression on radiosensitivity in renal carcinoma 786-O cells
... infected 786-O cells, the positive clones were obtained following puromycin ...as 786-O-Ku70, 786-O-siKu70, 786-O-vector and 786-O- ...
6
Original Article Parthenolide induces apoptosis and inhibits proliferation of human 786-O kidney cancer cells in vitro
... non-PTL-treated 786-O cells to ...of 786-O cells with 0, 5, 10, 15, and 20 μM of PTL for 48 hours induced apoptosis in these cells, in a dose-dependent ...on 786-O ...
9
Original Article Effects of autophage on the proliferation and apoptosis of clear cell renal carcinoma 786-O cells
... Abstract: Objective: Autophagy plays important roles in tumor occurrence and development. The present study aimed to investigate the association between autophagy and apoptosis in clear cell renal carcinoma cells ...
8
Radiation induces premature chromatid separation via the miR- 142-3p/Bod1 pathway in carcinoma cells
... in 786-O and A549 ...in 786-O cells by suppressing Bod1 ...sensitized 786-O and A549 cells to X-ray ...in 786-O and A549 ...
14
Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism
... Several reports have demonstrated a direct correlation between the loss of VHL expression and alterations in the cellular metabolism, leading to an altered tumor microenvironment, such as high lactate concentrations and ...
12
β-Catenin promotes cell proliferation, migration, and invasion but induces apoptosis in renal cell carcinoma
... Abstract: β-Catenin (CTNNB1 gene coding protein) is a component of the Wnt signaling path- way that has been shown to play an important role in the formation of certain cancers. Abnormal accumulation of CTNNB1 ...
14
... Molecular targeted therapy is a standard treatment for patients with advanced renal cell carcinoma (RCC). Sunitinib is one of the most common molecular-targeted drugs for metastatic RCC. Molecular mechanisms of sunitinib ...
17
Anti-proliferative potential of Glucosamine in renal cancer cells via inducing cell cycle arrest at G0/G1 phase
... Results: Our data showed that Glucosamine significantly inhibited the proliferation of renal cancer 786-O and Caki-1 cells in a dose-dependent manner. Besides, Glucosamine treatment resulted in cell cycle ...
8
A CCR4 antagonist reverses the tumor promoting microenvironment of renal cancer
... We considered body, Affi-5 19, abrogated the migration of 786-O cells to CCL17, based on the data presented previously, as well as the published further confirming that the CCR4 receptor[r] ...
14
Original Article Nucleobindin 2 (NUCB2) in renal cell carcinoma: a novel factor associated with tumor development
... NUCB2 was first reported in 2006 by Oh-I as a metabolic factor reducing food intake and improving energy homeostasis [1]. The gene is located on chromosome 11, consisting of 14 exons spanning 54,785 nucleotides, which ...
8
Downregulation of VEGFA inhibits proliferation, promotes apoptosis, and suppresses migration and invasion of renal clear cell carcinoma
... RCCC 786-O and human renal tubular epithelial HK-2 cells were purchased from American Type Culture Collection and were cultured with RPMI 1640 medium (Hyclone, Logan, UT, USA) containing 10% fetal bovine ...
11
Reversine, a substituted purine, exerts an inhibitive effect on human renal carcinoma cells via induction of cell apoptosis and polyploidy
... cells 786-O and ACHN were used to evaluate the proliferation inhibitive effect of ...that 786-O and ACHN cells decreased in time- and dose- dependent manners after reversine ...
11
Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma
... Cell invasive ability was determined using the Transwell test kit (Corning, NY, USA). Briefly, matrigel was mixed with 1640 medium at a ratio of 1:7 and 100 μl was added to each upper-transwell then placed into the ...
9
Species-Specific Regions of Occludin Required by Hepatitis C Virus for Cell Entry
... cinoma 786-O cells, which express high levels of CD81, SR-BI, and CLDN1 but are not permissive to HCV infection due to insufficient OCLN levels (44), were transduced with these pro- viruses packaged within ...
13
Original Article Combination of metformin and valproic acid synergistically induces cell cycle arrest and apoptosis in clear cell renal cell carcinoma
... The human renal cancer cell line 786-O and Caki-2 were purchased from the Cell Bank of the Chinese Academy of Sciences (Shanghai, China). It was routine maintained in RPMI1640 containing 100 ml/L fetal ...
6
Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells
... The molecular mechanisms underlying the Warburg effect are pleiotropic, involving defects and gain-of function modulations of glycolytic and mitochondrial enzymes. These mechanisms might differ between types of cancer ...
11
miR-96 suppresses renal cell carcinoma invasion via downregulation of Ezrin expression
... and 786-O cells transfected with a miR-96 mimic or inhibitor using wound healing assays, Transwell assays and western ...and 786-O cells increased following transfection of cells with miR-96 ...
9
Dicer suppresses MMP-2-mediated invasion and VEGFA-induced angiogenesis and serves as a promising prognostic biomarker in human clear cell renal cell carcinoma
... down 786-O and ACHN cells while significantly slowed in the conditioned medium form Dicer over-expression 786-O and ACHN cells compared with the corresponding controls (Figure ...down ...
15
The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway
... P2RX6 promotes RCC cell migration and invasion in vitro We first tested P2RX6 protein expression in multiple RCC cell lines (SN12-PM6, OS-RC-2, 786-O, SW839, A498) vs. normal renal proximal tubule ...
16
Original Article Upregulation of UHRF1 promotes renal cancer metastasis and poor prognosis
... lated with lower overall survival rates and could be an independent prognostic factor in patients with RCC. To further understand the biological function of UHRF1 in RCC cell process, in vitro experiments were conducted. ...
9