8-OHdG
The significance of the alteration of 8-OHdG in serous ovarian carcinoma
... The 8-hydroxy-2′-deoxyguanosine (8-OHdG) is one of the best-characterized oxidized ...bases. 8-OHdG in DNA could lead to mis-incorporation of adenines op- posite the ...
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High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors
... exogenous 8-OHdG could be a functional molecule in the regulation of oxidative stress-induced gastritis through binding or blocking the related signals responsible for the gastric inflammatory ...
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EXPRESSION OF GLYPICAN-3(GPC-3) AND 8-HYDROXYDEOXYGUANOSINE (8-OHDG) IN CHRONIC HEPATITIS C AND RELATIONSHIP WITH HEPATOCELLULAR CARCINOMA
... migration. 8-Hydroxydeoxyguanosine (8-OHdG) is an oxidatively modified promutagenic DNA that is produced by oxygen radicals and is recognized as a useful marker in estimating DNA damage induced by ...
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Comet Assay and Urinary 8-OHdG: A Marker of Oxidative Stress in Oral Cancer with Puducherry Population
... Several clinical studies have demonstrated clearly the association of harmful paranormal oral habits, such as betel quid chewing, tobacco chewing, paan chewing, smoking bidi or cigarette with occurrence of oral cancer ...
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Effect of Scaling and Root Planing on Levels of 8-Hydroxy Deoxyguanosine (8-OHdG) in Gingival Crevicular Fluid of Chronic Periodontitis Patients With and Without Type II Diabetes Mellitus
... of 8-OHdG evaluated using LC-MS/MS ...salivary 8-OHdG levels to monitor the treatment response of ...quantifying 8-OHdG in whole saliva. 8-OHdG level was ...
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Original Article Content change and clinical significance of oxidation damage products 8-OHdG, 4-HNE and NTY in hemangioma tissue
... of 8-OHdG, 4-HNE and NTY in different stages of hemangioma and normal skin tissues adjacent to the ...of 8-OHdG, 4-HNE and NTY was statistically significantly higher in proliferative ...
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Immunohistochemical detection of 8-hydroxy deoxyguanosine (8-OHdG): A Biomarker of oxidative DNA damage in oral submucous fibrosis
... Tobacco-smoking, radiation, air -pollution, ultra -violet radiation, mitochondrial damage, chronic inflammation and chronic systemic diseases lead to uncontrolled oxidative damage which may progress to produce ...
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Level of 8-OHdG in drained dialysate appears to be a marker of peritoneal damage in peritoneal dialysis
... that 8-OHdG level in drained dialysate may be more strongly correlated with peritoneal injury in PD patients who have a past history of peritonitis than in PD patients who do not, beyond patients’ PD dura- ...
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Relationships of sirt1 and 8 ohdg with resilience, depression and cognition in the elderly
... of 8-hydroxy-2'- deoxyguanosine ...of 8-OHdG have been found in different pathologies and chronic-degenerative diseases (Valavanidis et ...of 8-OHdG at increased plasma or urine ...
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Lower serum levels of total cholesterol are associated with higher urinary levels of 8-hydroxydeoxyguanosine
... [10]. 8-hydroxydeoxyguanosine (8-OHdG) is a reliable marker of oxidative DNA damage and its concentrations in urine have been shown to predict cancer risk ...urinary 8-OHdG and serum ...
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Original Article Pterostilbene protects against traumatic spinal cord injury via inhibiting inflammation and oxidative stress
... Then, we investigated whether PTE treatment reduced oxidative stress post SCI. At 7 days post-SCI, the levels of MDA and 8-OHdG in the spinal cord tissue were determined. The results indicated that SCI ...
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Protective Mechanisms of Omega-3 Fatty Acids Against Hepatotoxic Impact of Cadmium Exposure in Rats
... [30] 8-hydroxy-2'-deoxyguanosine (8-OHdG) is the major form of the DNA ...increased 8-OHdG concentration with respect to control rats ...of 8-OHdG , a fundamental signal ...
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Changes in peripheral mitochondrial DNA copy number in metformin-treated women with polycystic ovary syndrome: a longitudinal study
... Plasma 8-OHdG was assessed using the HT 8-oxo-dG ELISA Kit II (R&D Systems, Inc., Minneapolis, MN, USA; catalog no. 4380–096-K). Peripheral blood leukocyte DNA was extracted from the buffy coat ...
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Oscillating glucose induces microRNA-185 and impairs an efficient antioxidant response in human endothelial cells
... Results: After exposure to constant high glucose SOD-1 and GPx-1 increased, while in oscillating glucose SOD-1 increased and GPx-1 did not. SOD-2 and CAT remained unchanged under both conditions. A critical involvement ...
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Original Article Asiatic acid attenuates traumatic brain injury via upregulating Nrf2 and HO-1 expression
... Abstract: The neuroprotective role of asiatic acid (AA) against cerebral ischemia has been previously reported. However, whether AA attenuates traumatic brain injury (TBI) has not been investigated. The current study ...
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Oxidative stress induced sperm DNA damage, a possible reason for male infertility
... of 8-OHdG with MDA and PHP ...of 8-OHdG with SOD, TAS, motility, sperm count and morphology (in all cases ...and 8-OHdG level and sperm density and sperm number ...
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Beneficial effects of curcumin nano-emulsion on spermatogenesis and reproductive performance in male rats under protein deficient diet model: enhancement of sperm motility, conservancy of testicular tissue integrity, cell energy and seminal plasma amino acids content
... L-arginine and taurine were positively correlated to the sperm cell concentration and progressive sperm motility. Our results revealed that ingesting curcumin and nano-curcumin protected against the adverse effects of ...
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Oxidative stress in prostate hyperplasia and carcinogenesis
... inhibitors; 8-EPI, 8-isoprostanes; 8-OHdG, 8-hydroxy-2'-deoxyguanosine; ADT, Androgen deprivation therapy; Akt, Alpha serine/threonine-protein kinase; AP1, Activator protein 1; AR, ...
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Oxidative DNA damage and oxidized low density lipoprotein in Type II diabetes mellitus among patients with Helicobacter pylori infection
... All statistical analyses were done using a Statistical Pack- age for the Social Sciences (SPSS); v.20 (SPSS Inc., Chi- cago, IL, USA). Continuous variables were expressed as mean ± SD, whereas categorical variables were ...
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Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients
... deoxyguanosine, 8-OHdG is used to determine the extent of DNA damage and evaluate oxidative stress levels in patients ...serum 8-OHdG levels were significantly associated with the common Hp ...
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