α actinin
Mice deficient in α actinin 4 have severe glomerular disease
... encodes α -actinin-4, cause a form of human focal and segmental glomerulosclerosis ...detectable α -actinin-4 protein ...of α -actinin-4, histologic examination of mice showed ...
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Recombinant α actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis
... Alpha- actinin (TVAG_190450; ...that α-actinin is one of the most common immunogens that can be detected in the sera from women infected with ...that α- actinin was conserved across ...
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Reversible SAHH inhibitor protects against glomerulonephritis in lupus prone mice by downregulating renal α actinin 4 expression and stabilizing integrin cytoskeleton linkage
... of α -actinin-4 and restored the loss of podocytes in the glomeruli of NZB/WF1 ...mutant α -actinin-4 exhibited altered structural characteristics and localized abnormally; thus, interventions ...
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A “human knockout” model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations
... in α-actinin-2 protein content at baseline, with no evidence for a greater adaptive response to a single session of high-intensity interval exercise in participants with the ACTN3 XX ...
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Recombinant α actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis
... of α-actinin (ACT-F, 14–469 aa and ACT-T, 462–844 aa) were amplified from cDNA and cloned into pET-32a (+) expression vector by insertion at Kpn I/Sal I restriction ...of α-actinin an equal ...
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Synaptopodin regulates the actin bundling activity of α actinin in an isoform specific manner
... with α-actinin-4 in podocytes (Figure ...with α-actinin in a dotted pattern along stress fibers (Figure ...of α-actinin-4 in podocytes preceded the expression of synaptopodin ...
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Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4
... residue remains to be clarified. In conclusion these results suggest that in the diabetic kidney the morphological changes in the glomerulus and tubules may be ascribed to the abnormal O-GlcNAcylation of cytoskeletal ...
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Epitopes of the Highly Immunogenic Trichomonas vaginalis α Actinin Are Serodiagnostic Targets for Both Women and Men
... serum-based point-of-care diagnostic test that utilizes a highly specific target. Our data show that the 558-amino-acid ACT-P2 is a good target for detection of antibodies in both women and men seropositive for T. ...
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Alpha-actinin binding kinetics modulate cellular dynamics and force generation
... Contributed by Martin R. Pollak, March 25, 2015 (sent for review January 14, 2015) The actin cytoskeleton is a key element of cell structure and movement whose properties are determined by a host of accessory proteins. ...
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AFM Investigation of the Organization of Actin Bundles Formed by Actin Binding Proteins
... bundles formed with either the Caprice or the α-actinin protein were centrifuged onto a piece of freshly cleaved mica placed at the bottom of a microcentrifuge tube. The piece of mica was then removed from ...
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Molecular interactions of the mammalian intermediate filament protein synemin with cytoskeletal proteins present in adhesion sites
... to α-dystrobrevin, a component of the dystrophin-associated protein complex that interacts directly with dystrophin (Mizuno et ...Interestingly, α-actinin, vinculin, dystrophin, and ...
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alpha-Actinin interacts with rapsyn in agrin-stimulated AChR clustering
... neurons, α-actinin has been found to interact directly with NMDA receptors, anchoring them to the underlying F-actin ...Also, α- actinin is thought to play a role in the formation and ...
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The role of alpha-actinin-4 in human kidney disease
... The α -actinins are 100 kD rod shaped proteins that form head-to-tail homodimers ...[18]. α -Actinin mono- mers contain three distinct domains: an N-terminal actin binding domain (ABD), four ...
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The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish
... manually using forceps. Deyolking was followed by permeabilization with proteinase K (3 μ m/ml) in 1 ml PBS/0.1%Tween20 (50-54 hpf for 20 min; 72 hpf for 50 min; 79-80 hpf for 1 h). After permeabilization embryos/ larvae ...
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Structural and biochemical characterisation of utrophin and dystrophin spectrin repeat domains : submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry, Massey University, Palmerston North, NZ
... In this thesis, high-resolution structures of the N-terminal first spectrin repeat domains from utrophin and dystrophin have been determined by x-ray crystallography to 1.95 and 2.3 Å. Despite multiple structures of ...
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Alpha actinin binding antibodies in relation to systemic lupus erythematosus and lupus nephritis
... for α -actinin-binding Abs because nei- ther DNA nor α-actinin is normally an available target antigen in the ...of α -actinin in extra-cellular ...intraglomerular ...
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Motieven voor het kijken naar reality tv : bestaat er een verschil tussen Nederlandse en Duitse studenten?
... De stellingen van de motieven personal identification α=.89, entertainment α=.81, mood change α=.80, pass time α=.73, companionship α=.85, social interaction α=.72 en voyeurism α=.90 heb[r] ...
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Ditrityl α,α trehalose hexaacetate
... bonded water molecule (Spek, 2001). No hydrogen bonds are present. The substitution at C1,C1′ is α , α , with C1—O1 = 1.417 (3) Å and the angle subtended at O1 = 113.4 (2)°. The absolute configuration ...
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Redetermination of α ammonio α methylpropionoate
... The redetermined structure of the title compound, C4H9NO2, comprises a simple amino acid derivative arranged in an extensive hydrogen-bonded network, with the three hydrogen-bond donor e[r] ...
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Impact of mesenchymal stem cells’ secretome on glioblastoma pathophysiology
... The human glioblastoma cell line SNB-19 was kindly pro- vided by Rui M. Reis, (Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal) and the human glioblastoma cell line ...
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