a competing endogenous RNA
Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
... nucleolar RNA host gene 6 (SNHG6) has been reported in different cancers, such as hepatocellular carcinoma, colorectal cancer, and lung ...a competing endogenous ...
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<p>Long Noncoding RNA <em>FGD5-AS1</em> Acts as a Competing Endogenous RNA on microRNA-383 to Enhance the Malignant Characteristics of Esophageal Squamous Cell Carcinoma by Increasing SP1 Expression</p>
... Methods: ESCC tissue samples and paired normal adjacent tissues were collected to quantify FGD5-AS1 expression by reverse-transcription quantitative PCR. The effects of FGD5-AS1 on ESCC cell proliferation, apoptosis, ...
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The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer
... Notes: (A) hgc-27 cells were transfected with negative control, siTincr, or siTincr + miR-375 inhibitor and injected subcutaneously into 10 nude mice per flank. Surgical resections of hgc-27 xenograft tumors on week 4 ...
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Long noncoding RNA <em>CRNDE</em> functions as a competing endogenous RNA to promote metastasis and oxaliplatin resistance by sponging miR-136 in colorectal cancer
... noncoding RNA (lncRNA) that is highly elevated in colorectal cancer and many other solid tumors but its functions on metastasis and oxaliplatin (OXA) resistance are ...a competing endogenous ...
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The lncRNA myocardial infarction associated transcript-centric competing endogenous RNA network in non-small-cell lung cancer
... Background: The leading cause of death for cancer is lung cancer, of which the majority sub- type is non-small cell lung cancer (NSCLC). Recent studies have shown long non-coding RNAs are transcribed and contribute to ...
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<p>Long Noncoding RNA CCAT1 Functions as a Competing Endogenous RNA to Upregulate ITGA9 by Sponging MiR-296-3p in Melanoma</p>
... noncoding RNA (lncRNA) composed of more than 200 nucleotides in length and were commonly regarded as untranslational transcripts without protein- coding ...canonical competing endogenous RNA ...
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Long noncoding RNA SNHG6 functions as a competing endogenous RNA by sponging miR-181a-5p to regulate E2F5 expression in colorectal cancer
... Background: Long noncoding RNAs (lncRNAs) have been identified as a novel class of regulators implicated in diverse biological processes in human cancers. Currently, evidence have shown that SNHG6, a cancer-associated ...
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Competing endogenous RNA networks: tying the essential knots for cancer biology and therapeutics
... (HCV) RNA, and utilized HITS-CLIP and single-cell measurements to demonstrate that functional sequestration of miR-122 by the HCV RNA reduced miR-122 binding to its endogen- ous target mRNAs ...
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Progress in Competing Endogenous RNA and Cancer
... The 3’-UTR of Versican mRNA act as ceRNA, it not only play an important role in liver cancer [35], but also can influence breast cancer cell’s growth by competitive binding with miR-136,[r] ...
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Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression
... all four predicted miR-181 binding sites (pMIR-MEG3- MUT1-4). The miR-181 family contains four miRNAs (miR-181a/b/c/d), which are transcribed from three sepa- rated gene loci. Here, we mainly focused on miR-181a to ...
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Comprehensive analysis of a long noncoding RNA-associated competing endogenous RNA network in colorectal cancer
... For each of the DEmRNAs, DElncRNAs, and DEmiRNAs in the ceRNA network, the CRC patients were classified into either a high expression group or a low expression group using the median expression value of the specific ...
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Identification of a competing endogenous RNA network associated with prognosis of pancreatic adenocarcinoma
... pancreatic RNA expression and clinical information of 445 PAAD patients and 328 normal subjects were downloaded from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC) and ...
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Identification and Analysis of P53-Mediated Competing Endogenous RNA Network in Human Hepatocellular Carcinoma
... Here, the differential expressed mRNAs, lncRNAs and miRNAs in response to doxorubicin (Dox) treatment, an agent induced activity of p53, were obtained through RNA-seq. In order to construct a p53-mediated ceRNA ...
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The epithelial to mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network
... Competing endogenous RNAs (ceRNAs) have binding sites for a common set of miRs and regulate each other’s expression by functioning as miR ...noncoding RNA spe- cies that can function as ceRNAs ...
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LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d
... translation followed by Coomassie stained PAA Gel, and found that NONMMUT 022555 is really a non-coding RNA without protein-coding function (Fig. S2). Thus, we focused on examining NONMMUT 022555 in our subsequent ...
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Biomarker and competing endogenous RNA potential of tumor-specific long noncoding RNA in chromophobe renal cell carcinoma
... Results: One hundred and forty-two lncRNAs were found to be differentially expressed between the cancer and normal tissues (fold change $1.5, P,0.001). Among them, 12 lncRNAs were also differentially expressed with the ...
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<p>Long Non-Coding RNA TTN-AS1 Serves as a Competing Endogenous RNA of miR-195 to Facilitate Clear Cell Renal Cell Carcinoma Progression</p>
... extracted using the PARIS Kit (Invitrogen). First strand cDNA was then generated using the PrimerScript ™ reagent Kit (TaKaRa, Dalian, China). PCR ampli fi cation was carried out using a SYBR Green PCR kit (TaKaRa) on an ...
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<p>Construction and Analysis of a Long Non-Coding RNA-Associated Competing Endogenous RNA Network Identified Potential Prognostic Biomarkers in Luminal Breast Cancer</p>
... The RNA-seq data and miRNA-seq data of luminal A breast cancer in the The Cancer Genome Atlas (TCGA) database were downloaded and compared with those in the miRcode database to obtain lncRNA – miRNA relationship ...
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Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives
... target RNA transcripts ...of endogenous miRNA-targets (such as PAR-CLIP and HITS-CLIP) show large number of miRNA binding sites in their target mRNA sequences [6, ...
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C-Myc functions as a competing endogenous RNA in acute promyelocytic leukemia
... Based on the above knowledge, it could be speculated that let-7 family members probably would play a pivotal role through modulating the levels of c-Myc and other let-7-responsive genes to regulate the exquisite balance ...
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