α-galactosylceramide
Administration of α-Galactosylceramide Improves Adenine-Induced Renal Injury
... to α -galactosylceramide ( α GalCer). α GalCer promotes a complex mixture of Th1 and Th2 cytokines, as interferon (IFN)- γ and interleukin ...J α 18KO and IFN- γ KO ...J α 18KO ...
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Novel thioglycoside analogs of α galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells
... TCR α -chain (V α 24J α 18 in humans and V α 14J α 18 in mice) paired with one of a limited number of β -chains, which recognizes glycolipid antigens bound to ...glycolipid, α ...
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Activation of Invariant Natural Killer T Cell Subsets in C57BL/6J Mice by Different Injection Modes of α-galactosylceramide
... activator, α-GalCer is a galactosylceramide found in marine sponge extracts, which stimulates CD1d-restricted iNKT cell activation, 4,15 effectively activating iNKT1, iNKT2, and ...iNKT17. α-GalCer ...
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Retinoic Acid and α-Galactosylceramide Differentially Regulate B Cell Activation In Vitro and Augment Antibody Production In Vivo
... All-trans-retinoic acid (RA) promotes the maturation and differentiation of B cells, which are known as a type of professional antigen-presenting cells. We show here that CD1d, a major histocompatibility complex class ...
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Dendritic cells combined with tumor cells and α galactosylceramide induce a potent, therapeutic and NK cell dependent antitumor immunity in B cell lymphoma
... and α-GalCer (Mix + GalCer vaccine) is very effective in eradicating B cell lymphoma in vivo as a therapeutic ...and α-GalCer prior to injection into tumor-bearing mice can induce the strongest antitumor ...
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Combination of the toll like receptor agonist and α-Galactosylceramide as an efficient adjuvant for cancer vaccine
... MPL, α-GalCer, pcDNA3, vehicle or PBS, whereas tumor growth was significantly retarded in mice that received DNA vaccine expressing E7 protein with or without ...MPL, α-GalCer, pcDNA3, vehicle or PBS groups ...
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Exogenous Activation of Invariant Natural Killer T Cells by α Galactosylceramide Reduces Pneumococcal Outgrowth and Dissemination Postinfluenza
... IMPORTANCE Despite the application of vaccination programs and antiviral drugs, influenza A virus (IAV) infection is responsi- ble for widespread morbidity and mortality (500,000 deaths/year). Influenza infections can ...
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Temporal regulation of natural killer T cell interferon gamma responses by β-catenin-dependent and -independent Wnt signaling
... antigen, α -galactosylceramide ( α -GalCer) using a mouse ...of α -GalCer challenge, myeloid-specific Wls deficiency, as well as pharmacologic targeting of Wnt release using the small molecule ...
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Modulation of NKT cells and Th1/Th2 imbalance after α-GalCer treatment in progressive load-trained rats
... of α-galactosylceramide (α-GalCer), a synthetic glycol- ipid activator of NKT cells [8], the Th1/Th2 lympho- cyte balance during overtraining or excessive ...
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Activation of human invariant natural killer T cells with a thioglycoside analogue of ? galactosylceramide
... glycolipid, α- galactosylceramide (α-GalCer), a potent agonist for murine and human iNKT cells [5] has been used as the prototype antigen for most studies on iNKT ...with α-GalCer, iNKT cells ...
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Invariant natural killer T cells are functionally impaired in patients with systemic sclerosis
... Abbreviations α-GalCer: α-Galactosylceramide; Ab: Antibodies; ACA: Anti-centromere antibodies; ANA : Anti-nuclear antibodies; Nucleoli: Anti-nucleoli antibodies; SCL70: Anti-topoisomeras[r] ...
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Alpha galactosylceramide enhances mucosal immunity to oral whole cell cholera vaccines
... adjuvant α -Galactosylceramide ( α -GalCer) to strongly enhance intestinal bacterium- and toxin-speci fi c IgA responses to the OCV, Dukoral ® in C57BL/6 and BALB/c ...
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A randomized phase II study to assess the effect of adjuvant immunotherapy using α GalCer pulsed dendritic cells in the patients with completely resected stage II–IIIA non small cell lung cancer: study protocol for a randomized controlled trial
... limited α -chain (V α 24J α 18 in humans) and a β -chain (V β 11 in ...recognize α -galactosylceramide ( α -GalCer), a type of gly- colipid displayed by CD1d, and are ...
7
Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in established murine cancer model
... Alpha-galactosylceramide (GalCer) is identified as the ligand of Vα14+ natural killer (NK) T cells. Vα14+ NKT cells distinct from mainstream T cells, B cells and NK cells have been identified. These cells are ...
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Alpha galactosylceramide enhances protective immunity induced by DNA vaccine of the SAG5D gene of Toxoplasma gondii
... by α-GalCer and plasmids in mice were detected by ELISA at weeks 0, 2, 4 and ...or α-GalCer/pEGFP- C1-SAG5D, especially after the third ...PBS, α-GalCer or pEGFP-C1 alone also generated IgG ...or ...
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α,α,4 Trichloro α phenyl o tolyl dichlorophosphinate
... Data collection: APEX2 Bruker, 2003; cell re®nement: APEX2; data reduction: SAINT±Plus Bruker, 2003; programs used to solve structure: SHELXS97 Sheldrick, 1997; programs used to re®ne st[r] ...
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Redetermination of α ammonio α methylpropionoate
... The redetermined structure of the title compound, C4H9NO2, comprises a simple amino acid derivative arranged in an extensive hydrogen-bonded network, with the three hydrogen-bond donor e[r] ...
5
Ditrityl α,α trehalose hexaacetate
... The title compound was prepared by reacting anhydrous α , α -trehalose with trityl chloride in pyridine, followed by excess acetic anhydride after 30 min. The mixture was left stirring for 4 h, then ...
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Specialized role of migratory dendritic cells in peripheral tolerance induction
... In this study, we used an antigen-targeting approach to address in vivo the ability of skin migratory versus lymphoid-resident DCs to promote the development of antigen-specific Tregs. Taking advantage of the ...
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Motieven voor het kijken naar reality tv : bestaat er een verschil tussen Nederlandse en Duitse studenten?
... De stellingen van de motieven personal identification α=.89, entertainment α=.81, mood change α=.80, pass time α=.73, companionship α=.85, social interaction α=.72 en voyeurism α=.90 heb[r] ...
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