a nuclear localization signal
Multifunctionality of a Picornavirus Polymerase Domain: Nuclear Localization Signal and Nucleotide Recognition
... a nuclear localization ...a nuclear localization signal (NLS) and in template binding is also involved in nucleo- tide recognition and can affect the incorporation of nucleotide ...
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Identification of a non-canonical nuclear localization signal (NLS) in BRCA1 that could mediate nuclear localization of splice variants lacking the classical NLS
... non-classical signal sequences of experimentally proven nuclear ...a nuclear localization signal, we constructed two different fusion proteins using the vector enhanced green ...
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Characterization of the Nuclear Localization Signal of the Borna Disease Virus Polymerase
... specific nuclear localization signal(s) (NLS[s]) within the primary amino acid sequence of the karyophilic protein ...the nuclear pore complex and is im- ported into the nucleus through a ...
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Biologic and Immunologic Effects of Knockout of Human Cytomegalovirus pp65 Nuclear Localization Signal
... prototypic nuclear localization signal (NLS) in which arginine and lysine predominate within a bipartite motif in which short regions of basic amino acids are separated by 10 or more nonconserved ...
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Nuclear Import of Bovine Papillomavirus Type 1 E1 Protein Is Mediated by Multiple Alpha Importins and Is Negatively Regulated by Phosphorylation near a Nuclear Localization Signal
... its nuclear localization signal but not to importins ␣ 1 and ␣ ...the nuclear import of BPV1 E1 has been ...E1 nuclear import (28, ...
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Nuclear Import of Epstein-Barr Virus Nuclear Antigen 1 Mediated by NPI-1 (Importin α5) Is Up- and Down-Regulated by Phosphorylation of the Nuclear Localization Signal for Which Lys379 and Arg380 Are Essential
... (EBV) nuclear antigen 1 (EBNA-1) is essential for replication of episomal EBV DNAs and maintenance of ...on nuclear translocation of Ser phosphorylation of the EBNA-1 nuclear localization ...
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Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin
... here, nuclear localization signal (NLS)- modified polymeric micelles were studied with the aim of improving nuclear drug ...proton nuclear magnetic resonance spectroscopy, dynamic light ...
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A Nuclear Localization Signal in Herpesvirus Protein VP1-2 Is Essential for Infection via Capsid Routing to the Nuclear Pore
... Growth characteristics of K.VP1-2 ⌬ NLS. We previously identi- fied a short, highly conserved basic motif in VP1-2, embedded within an otherwise poorly conserved region at the N terminus of the protein (Fig. 1a). We ...
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Oxadiazols: a New Class of Rationally Designed Anti-Human Immunodeficiency Virus Compounds Targeting the Nuclear Localization Signal of the Viral Matrix Protein
... of nuclear translo- cation of the HIV preintegration ...HIV-1 nuclear import by targeting the nuclear localization signal (NLS) in the matrix protein ...inhibited nuclear import ...
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The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site.
... Functionally important domains in the SV40 large TAg sequence are identified, including the nuclear localization signal and several phosphorylation sites, among them the site for p34cdc2[r] ...
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The role of nuclear localization signal in parvovirus life cycle
... for nuclear targeting of VP2 ...the nuclear localization signal of B19 VP2 capsid protein, the localization of full-length VP2 (aa VP 228-781) protein and a C-terminal, truncated form ...
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Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells
... subcellular localization of viral proteins, especially in the nucleus, may contribute to cell apoptosis, viral replication or host cell proliferation [9, ...the nuclear localization signal ...
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Nuclear Localization Signal of HIV-1 as a Novel Target for Therapeutic Intervention
... (1992) Active nuclear import of human immunodeficiency virus type 1 preintegra- tion complex. Stevenson M, Bukrinsky M, Haggerty S[r] ...
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Functional Characterization of the Nuclear Localization Signal for a Suppressor of Posttranscriptional Gene Silencing
... these mutant viruses retained the ability to replicate in proto- plasts (18). TYLCV-C infection, and indeed transient expres- sion of the C2 protein via agroinfiltration, effectively overcame the local and systemic ...
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Interaction of the Vp3 Nuclear Localization Signal with the Importin α2/β Heterodimer Directs Nuclear Entry of Infecting Simian Virus 40
... Mutant NO-SV40 DNA was then transfected into the cells, and DNA that had entered the nucleus was allowed to initiate a single infection cycle. Provided that the mutation did not affect virion assembly in the nucleus, ...
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Inhibition of HIV 1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal
... its nuclear transport appears to be dependent on the importin α/β heterodimer have also demonstrated by Hearps and Jans ...necessarily nuclear import ...its nuclear import. Nuclear ...
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Differential Intracellular Compartmentalization of Herpetic Thymidine Kinases (TKs) in TK Gene-Transfected Tumor Cells: Molecular Characterization of the Nuclear Localization Signal of Herpes Simplex Virus Type 1 TK
... the nuclear localization of HSV-1 TK is crucial for reactivation and also that changing the intracellular localization of HSV-1 TK from the nucleus to the cytosol (by deleting the NLS) would affect ...
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Nuclear targeting of the tegument protein pp65 (UL83) of human cytomegalovirus: an unusual bipartite nuclear localization signal functions with other portions of the protein to mediate its efficient nuclear transport.
... direct nuclear import, confirming that this sequence con- tained a bona fide ...Xenopus nuclear protein N1 has a bipartite NLS with an ami- no-terminal basic sequence (RKKKRK) which resembles both the SV40 ...
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A nuclear targeting system in Plasmodium falciparum
... bipartite signal sequence to facilitate apicoplast targeting and membrane translocation ...a nuclear targeting technique in ...a nuclear carrier ...A nuclear localiza- tion signal (NLS) ...
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The arginine-rich domain of hepatitis B virus precore and core proteins contains a signal for nuclear transport.
... In order to investigate whether this sequence contains an unusual nuclear localization signal, a protein named lOG was created by fusing the proximal precore sequence to the amino termin[r] ...
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