a Tissue - type plasminogen activator
The thrombolytic tissue-type plasminogen activator (tpa)
... thrombolytic tissue-type plasminogen activator (tPA) was approved in 1996 by the Food and Drug Adminis- tration for treatment of acute ischemic ...
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Tissue type plasminogen activator increases the binding of glu plasminogen to clots
... Porcine tissue-type plasminogen activator (t-PA) increases the binding of 125I-glu- plasminogen to clots made from human plasma or purified fibrinogen in a time and t-PA concentration ...
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Tissue-Type Plasminogen Activator, Plasminogen Activator Inhibitor, and Histidine-Rich Glycoproteins in Stressed Human Newborns
... Tissue-type plasminogen activator antigen was determined by an enzyme-linked immuno- sorbent assay (ELISA) method using a commercial kit (Imubind-5- tPA, American Diagnostica).4’9 Plasmi[r] ...
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Regulation of seizure spreading by neuroserpin and tissue type plasminogen activator is plasminogen independent
... Tissue-type plasminogen activator (tPA) is a highly specific serine proteinase expressed in the CNS during events that require neuronal ...contrast, plasminogen-deficient mice show a ...
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A biochemical study of tissue type plasminogen activator in bovine milk
... hypothesis, tissue type plasminogen activator (t-PA) was isolated and purified from mid to late lactation bovine ...zymogen, plasminogen, to the active form plasmin, subsequently ...
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Localization of the binding site of tissue type plasminogen activator to fibrin
... recombinant tissue-type plasminogen activator after mild reduction and ...of tissue-type plasminogen ...two-chain tissue-type plasminogen ...
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Influence of the fast acting inhibitor of plasminogen activator on in vivo thrombolysis induced by tissue type plasminogen activator in rabbits Interference of tissue derived components
... Infusion of human tissue-type plasminogen activator (t-PA) produced similar degrees of thrombolysis in control and endotoxin-treated rabbits, although no free t- PA could be demonstrated[r] ...
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Recombinant plasminogen activator inhibitor 1 reverses the bleeding tendency associated with the combined administration of tissue type plasminogen activator and aspirin in rabbits
... D E Vaughan, … , M De Mol, D Collen J Clin Invest. 1989;84(2):586-591. https://doi.org/10.1172/JCI114202. The major side effect of thrombolytic therapy is bleeding; however, the pathogenesis of this potential ...
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39 kD protein inhibits tissue type plasminogen activator clearance in vivo
... Tissue-type plasminogen activator (t-PA) is a plasma serine protease that catalyzes the initial and rate-limiting step in the fibrinolytic ...
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alpha Fucose mediated binding and degradation of tissue type plasminogen activator by HepG2 cells
... Binding and degradation of tissue-type plasminogen activator by the human hepatoma cell line HepG2. On the reversible inter- action ofplasminogen activator inhibitor- 1 with tissue plasm[r] ...
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Evaluation of recombinant tissue-type plasminogen activator in adhesion prevention and neoangiogenesis in a rat experimental adhesion model
... # Springer-Verlag Berlin / Heidelberg 2006 Abstract This study was designed to test the effect of recombinant tissue-type plasminogen activator (rt-PA) in reducing adhesion formation and to ...
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Regulation of Locomotor activity in fed, fasted, and food-restricted mice lacking tissue-type plasminogen activator
... Jessica A. Krizo 1 , Linley E. Moreland 1 , Ashutosh Rastogi 1 , Xiang Mou 2 , Rebecca A. Prosser 3 and Eric M. Mintz 1* Abstract Background: Circadian rhythms of physiology and behavior are driven by a circadian clock ...
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Two receptor systems are involved in the plasma clearance of tissue type plasminogen activator (t PA) in vivo
... https://doi.org/10.1172/JCI118105. Tissue-type plasminogen activator (t-PA) is a serine protease, catalyzing the initial step in the fibrinolytic ...
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Uhl, Bernd (2015): Die Bedeutung der Plasminogenaktivatoren tissue-type-plasminogen activator und urokinase-type plasminogen activator für den Ischämie-Reperfusionsschaden. Dissertation, LMU München: Medizinische Fakultät
... Zymogen Plasminogen in der Leber gebildet und von dort in den Blutkreislauf ...Plasminogenaktivatoren tissue-type plasminogen activator (tPA) und urokinase-type ...
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Tissue type plasminogen activator is a neuroprotectant in the mouse hippocampus
... Each observation was repeated in cultures from 3 different animals (n = 10). Early and delayed preconditioning with tPA. For early and delayed precondi- tioning, we used hippocampal neurons at 10 days in vitro. For early ...
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Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface
... of plasminogen and tissue plasminogen activa- tor with native and activated platelets, to determine the amount of plasmin generated by various activators in the presence of platelets, and the ability ...
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Management of Plastic Bronchitis With Topical Tissue-type Plasminogen Activator
... ” type I casts, which are cellular with abundant fi brin, eosinophils, and Charcot-Leyden crystals, or “ nonin fl am- matory ” type II casts, which are acellular with mucin and little fi ...
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Human tissue-type plasminogen activator releases fibrinopeptides A and B from fibrinogen.
... These studies thus demonstrate that (a) rt-PA releases fibrin- opeptides A and B from fibrinogen thereby indicating that this enzyme is not specific for plasminogen, and (b) plasma fibri[r] ...
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The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans
... of tissue plasminogen activator: plasminogen activator inhibitor-1 complex and matrix metalloproteinase-3 are significantly ele- vated in cerebrospinal fluid of trauma patients and ...
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Thrombolysis with human extrinsic (tissue type) plasminogen activator in dogs with femoral vein thrombosis
... FIGURE 2 Venograms of a dog with femoral vein thrombosis before (left side) and after (right side) infusion of 100,000 IU of two-chain extrinsic plasminogen activator (extent of thrombol[r] ...
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