α7 Nicotinic acetylcholine receptor
α7 Nicotinic Acetylcholine Receptor (α7nAChR) Expression in Bone Marrow-Derived Non-T Cells Is Required for the Inflammatory Reflex
... producing acetylcholine, the terminal neu- rotransmitter in the ...circuit. Acetylcholine interacts with cyto kine producing macrophages in the red pulp and mar- ginal zone to suppress TNF release ...the ...
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Expression of the α7 nicotinic acetylcholine receptor in human lung cells
... of α7 mRNA between a representative SCLC cell line (NCI- H82), and human SAE cells from a non-smoker (informa- tion provided by Clonetics), a riboprobe was transcribed from the PCR fragment amplified by the gene ...
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Stimulation of the α7 Nicotinic Acetylcholine Receptor Protects against Neuroinflammation after Tibia Fracture and Endotoxemia in Mice
... bined with buprenorphine (Buprenex, 0.1 mg/kg subcutaneously [s.c.]). An open tibial fracture was performed under aseptic conditions as described previ- ously (13). A middle incision was per- formed on the left hind paw ...
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A Human-Specific α7-Nicotinic Acetylcholine Receptor Gene in Human Leukocytes: Identification, Regulation and the Consequences of CHRFAM7A Expression
... The human genome contains a variant form of the α 7-nicotinic acetylcholine receptor ( α 7nAChR) gene that is uniquely human. This CHRFAM7A gene arose during human speciation and recent data suggests ...
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Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor
... Several previous studies have demonstrated that the activity of neurotransmitters acting on ligand-gated ion channels such as the nicotinic acetylcholine receptor (nAChR) can be altered by compounds ...
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The α7 Nicotinic Acetylcholine Receptor Agonist GTS-21 Improves Bacterial Clearance in Mice by Restoring Hyperoxia-Compromised Macrophage Function
... of α7 nicotinic acetylcholine receptors (α7nAChRs) plays a critical role in the re- lease of nuclear HMGB1 into the extracel- lular milieu ...
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Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures
... of α7 subunit stimulation on the functional state of activated ...the α7 subunit and we demonstrated that, in addi- tion to inhibit TNF-α, the α7 agonist nicotine significantly up-regulated COX-2 ...
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α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation
... Epidemiological studies [19] have reported that the prevalence of PD is lower in smokers than in non- smokers, leading to the hypothesis that the reduced prevalence of PD in smokers may be due to the presence of nicotine ...
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Deficiency of α7 Nicotinic Acetylcholine Receptor Attenuates Bleomycin-Induced Lung Fibrosis in Mice
... line receptor α 7 (ab24644), anti-PTP1B (phospho S378) [EP1840Y] (ab76239), anti-collagen I (ab34710) and anti- choline acetyltransferase [EPR13024(B)] (ab181023) antibodies were from ABCAM (Cambridge, MA, ...
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α7 Nicotinic Acetylcholine Receptor Signaling Inhibits Inflammasome Activation by Preventing Mitochondrial DNA Release
... that α7 nAchR signaling prevents mitochondrial DNA release into ...Indeed, acetylcholine dose-dependently inhibited ATP-induced mitochondrial DNA release into cyto- plasm in WT macrophages (Figure ...
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Small changes in bone structure of female α7 nicotinic acetylcholine receptor knockout mice
... differentiation and bone degradation [28] the reduction of nicotinic receptors in α7KO might provoke the down-regulation of cathepsin K expression. In male α7KO we did not investigate cathepsin K gene expres- sion ...
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Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [18F]NS14490
... homomeric α7 nicotinic acetylcholine receptor (α7 nAChR), together with the heteromeric α4β2 nAChR, belongs to the cysteine-loop family of ligand-gated ion channels and they represent ...
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Nicotine stimulates collagen type I expression in lung via α7 nicotinic acetylcholine receptors
... of nicotinic receptors in lung tissue capable of signal transduction ...termed nicotinic acetylcholine receptors (nAChRs), are multimeric acetylcholine-triggered channel proteins that form ...
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Alpha7 nicotinic acetylcholine receptor is required for blood brain barrier injury related CNS disorders caused by Cryptococcus neoformans and HIV 1 associated comorbidity factors
... Abbreviations AIDS: Acquired immune deficiency syndrome; α7 nAChR: Alpha7 nicotinic acetylcholine receptor; BBB: Blood-brain barrier; BMEC: Brain microvascular endothelial Cells; CAPE: C[r] ...
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Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis
... 7-Nicotinic acetylcholine receptor; A β : Amyloid beta; AD: Alzheimer ’ s disease; ApoE: Apolipoprotein E; CDR: Clinical Dementia Rating; DMSO: Dimethyl sulfoxide; DSM IV: Diagnostic and Statistical ...
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The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation
... the nicotinic acetylcholine receptor α7 subunit to endotoxin chal- lenge (105) implies a critical role of the cholinergic anti-inflamma- tory pathway in regulation of peripheral ...
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Modulation of TNF Release by Choline Requires α7 Subunit Nicotinic Acetylcholine Receptor-Mediated Signaling
... of acetylcholine degradation, is a stable, natural, and se- lective agonist on ...that acetylcholine sup- presses TNF release from peritoneal mouse macrophages and human macro- phages (3,4), but it was ...
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Host cell-specific folding of the neuronal nicotinic acetylcholine receptor α7 and α8 subunits
... mutant receptor, without significantly altering other characteristics of the ACh response (Galzi et al, ...glycine receptor a l subunit, results in the reversal from cationic to anionic selectivity (Galzi ...
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Smoking cessation in Asians: focus on varenicline
... the nicotinic acetylcholine receptor α 4 β 2 subtype, which is believed to be responsible for mediating the reinforcing properties of ...with nicotinic acetylcholine receptors, ...
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Reduction in mRNA and protein expression of a nicotinic acetylcholine receptor alpha 8 subunit is associated with resistance to imidacloprid in the brown planthopper, Nilaparvata lugens
... et al. 2003). In the nematode Ascaris suum, changing the stoichiometry of the receptor reproduced two pharmacolog- ical subtypes of nAChRs (Williamson et al. 2009). When the ratio of Asu-unc-38 : Asu-unc-29 was 5 ...
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