αA-Crystallin
A specific phosphorylation regulates the protective role of αA-crystallin in diabetes
... of αA-crystallin in ret- inal glial cells had no effect on ER stress, suggesting a different role of αA-crystallin in this cell ...of αA-crystallin expressed by glial ...secrete ...
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Redox Activity of the Mini-αA-crystallin–Cu(II) Complex and Its Biological Relevance
... Fmoc-protected amino acids, Wang resin, benzazimidol, diisopropylcarbodiimide and piperidine were obtained from GL Biochem Ltd. (Shanghai China). Other reagents were all of AR grade. They were obtained from Aldrich ...
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αA-crystallin R49Cneomutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice
... encoding αA-crystallin (CRYAA), autosomal dominant nuclear cataract was shown to segregate in a four generation Caucasian family ...in αA-crystallin protein ...mutant ...
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Original Article A functional polymorphism in the promoter of αA-crystallin increases the risk of nAMD
... CRYAA, αA-crystallin; OCT, optic coherence tomography; ARM, age related maculopathy; MALD I-TOF-MS, matrix- assisted laser desorption/ionization time-of- flight mass spectrometry; OR, odds ratio; CI, ...
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The role of a lens survival pathway including sox2 and αA-crystallin in the evolution of cavefish eye degeneration
... A primary function of Sox2 is stem cell maintenance [57,58]. Therefore, sox2 downregulation could explain previous findings concerning the relative contributions of cell proliferation and apoptosis in the cavefish lens ...
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THE LOCUS ENCODING αA-CRYSTALLIN IS CLOSELY LINKED TO H-2K ON MOUSE CHROMOSOME 17
... To facili- tate studies of the genetics of lens crystallins and their involvement in heritable lens defects in mice, we have identified DNA restriction fragment length pol-[r] ...
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Polymorphism and Linkage of the αA-Crystallin Gene in t-Haplotypes of the Mouse
... Restriction fragment polymorphisms were used to order the aA-crystallin locus (Crya-1 ) relative to other genes in mouse t-chromatin and to investigate the relatedness of a-A-[r] ...
5
Wrapping the alpha crystallin domain fold in a chaperone assembly
... human αA crystallin, human αB crystallin, human Hsp27, Ciona intestinalis (Q95P25), Caenorhabditis elegans (HSP11_CAEEL), Drosophila melanogaster (HSP23_DROME), Arabidopsis thaliana (HSP12_ARATH), ...
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Different alpha crystallin expression in human age-related and congenital cataract lens epithelium
... of αA- crystallin and αB-crystallin mRNA and soluble protein levels were identified in the lens epithelium of age- related and congenital cataracts compared with the normal control ...of ...
6
The small heat shock protein aA-crystallin negatively regulates pancreatic tumorigenesis
... protein, αA-crystallin is also expressed in non- lenticular tissues including retina, spleen and thymus ...that αA-crystallin is significantly expressed in mouse pancreas ...of ...
16
Structure and interactions in α crystallin probed through thiol group reactivity
... human αA-crystallin in pAED4 vector was a gift from ...Pooled αA- and αB- crystallin fractions were then applied to Sephacryl S-300 HR size exclusion column ...both αA- and ...
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Study of Seismic Behavior of Retaining Walls A Review
... where, Wa = Weight of the failure wedge in active case αa = Angle of inclination of the failure surface with the horizontal in active case Qha = horizontal inertia force due to seismic a[r] ...
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Original Article Renal tumor with alpha b crystallin expression
... αB crystallin. Renal cell carcinoma also showed expression of αB crystallin in previous ...αB crystallin expression and renal cell carcinoma and urothelial ...αB crystallin expression ...
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Clay Mineral Transformation in the Weathering Crust: Evidence from the Kundara Clay Mine, Kerala
... nite assemblage is characteristic of the clay minerals of the weathering crust in south Kerala and tl1at halloysite is undergoing transformation into well-crystallin[r] ...
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Actin Binding Domains Direct Actin-Binding Proteins to Different Cytoskeletal Locations
... to investigate the dynamic localization of these proteins in living cells, the localization of the GFP-fusion proteins was examined by confocal microscopy. In growing, unpo- larized cells, GFP-FLN was highly enriched in ...
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Pegylated leptin antagonist with strong orexigenic activity in mice is not effective in chickens
... To determine whether our well-established leptin antagonist (Benoit et al., 2013; Chapnik et al., 2013; Niv-Spector et al., 2012; Shpilman et al., 2011), which blocks mammalian LEPRs, also blocks the cLEPR, we used our ...
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Urochordate beta gamma crystallin and the evolutionary origin of the vertebrate eye lens
... followed by addition of DNAse I and sonication (4 x 15 seconds) with cooling. The lysate was centrifuged at 18000 rpm at 4°C for 20 minutes, then the supernatant was dialysed overnight at 4°C using 6 kDa MWCO dialysis ...
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The Possibility of Particles Forming from a Bose-Einstein Condensate, in an Intense Magnetic or Gravitational Field
... with antiparallel chiralities axially coupled, it results in consequence –according to the cold genesis quasi-crystallin quark model of CGT, the possibility of particles forming starting with the forming of a ...
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Nonenzymatic glycation of human lens crystallin Effect of aging and diabetes mellitus
... lens crystallin, an extremely long- lived protein, from 16 normal human ocular lenses ...insoluble crystallin was determined after reduction with H-borohydride followed by acid hydrolysis, boronic acid ...
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Recurrent mutation in the crystallin alpha A gene associated with inherited paediatric cataract
... important for subunit exchange and oligomerization. It has been suggested that the deletion of this highly con- served amino acid which is located in a conserved motif (SRLFDQFFG), leads to disruption of the correct ...
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