ABC transporters
Biochemical interaction of anti HCV telaprevir with the ABC transporters P glycoprotein and breast cancer resistance protein
... on ABC transporters revealed that verapamil and TKIs (including imatinib, gefitinib, erlotinib and sunitinib) are inhibitors of P-gp as com- petitive inhibitors ...between ABC transporters and ...
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Enhanced acid-stress tolerance in Lactococcus lactis NZ9000 by overexpression of ABC transporters
... In this study, we performed transcriptome analysis in four recombinant strains to study the mechanisms underlying improved acid tolerance mediated by the ABC transporters. In addition, we also further ...
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Genetic Identification of Three ABC Transporters as Essential Elements for Nitrate Respiration in Haloferax volcanii
... After ABC transporters are typically composed of two mem- preparative cleavage, the fragment mixture was separated elec- brane subunits and two ATP-binding subunits, both of trophoretically and fragments of ...
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Investigation of the Role of ABC Transporters in Pyrethroids Resistance in the Major Malaria Vector Anopheles coluzzii from Northern Nigeria
... cassette transporters (ABC trans- porters) has been implicated in insecticides resistance in the major malaria vector Anopheles funestus and An ...of ABC transporters in pyrethroids resistance ...
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ABC transporters and NR4A1 identify a quiescent subset of tissue resident memory T cells
... subset of tissue-resident long-lived stem cells is characterized by the ability to efflux Hoechst dyes and is referred to as side population (SP) cells. Here, we have characterized a subset of SP T cells (Tsp cells) that ...
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ATP-binding cassette (ABC) transporters in normal and pathological lung
... ingly, Schultz et al. [71] observed that the survival of Mrp1 (-/-) mice inoculated with Streptococcus pneumoniae was better than of wild-type mice. This was accompanied by a lower LTC 4 concentration but a higher LTB 4 ...
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ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal
... When one of two NBDs of Pgp is inactivated, not only drug transport but also ATP hydrolysis of normal NBD is inhibited. This result indicates that two NBDs would func- tion cooperatively and they could not hydrolyze ATP ...
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Contribution of Genetic Variants of ABC Transporters (ABCC1 and ABCG2) Genes With the Pathogenesis of Colorectal Cancer
... Colorectal cancer (CRC) is one of the major cancers that is characterized with high percentage of morbidity worldwide due to the advanced metastatic cancer that developed via acquired drug resistance mechanisms. ...
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SNPs on ABC Transporters and in vivo Malaria Parasite Non Clearance after Chloroquine Treatment in Malian Children
... (ABC) transporters are efflux pumps frequently associated with multidrug resistance in many biological systems, including ...in ABC genes modulate in vivo and/or in vitro drug susceptibility, but the ...
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How to move an amphipathic molecule across a lipid bilayer: different mechanisms for different ABC transporters?
... ABCD transporters exhibit greater specificity for the acyl moiety of the transported substrate: how can this be reconciled with a model in which the liberated fatty acid flip-flops in the membrane? Interestingly, ...
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Peroxisomal ABC transporters
... The isolation and characterisation of mutant alleles have provided considerable insight into the functions of peroxi- somal ABC transporters in plants. The ped3 allelic series and the pxa1-1 mutant were ...
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Expression of Multidrug Resistance ATP Binding Cassette (ABC) Transporters in Canine Mammary Tumors
... of ABC transporters P-glycoprotein, MRP1, and MRP2 in a series of 43 canine mammary ...drug transporters and their capability to extrude toxins, drugs, and physiological substrates from cells [16], a ...
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ABC transporters are involved in defense against permethrin insecticide in the malaria vector Anopheles stephensi
... for ABC transporters, and investigated their expression profile after exposure to per- ...of ABC transporters in permethrin transport in ...the ABC transporter inhibitor verapamil in ...
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Plant ABC transporters
... fungal ABC transporters in drug resistance phenomena is well established [55], their involvement in pathogenic interactions with plants is only beginning to ...An ABC transporter (ABC1) was recently ...
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A Review on ATP Binding Cassette (ABC) Transporters
... by ABC transporters like P-gp, multidrug resistance proteins 1 and 2 (MRP1/2; ABCC1/2), MRP4 (ABCC4) and BCRP in the ...these transporters protect the central nervous system, effective drug treatment ...
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Using LC–MS/MS-based targeted proteomics to monitor the pattern of ABC transporters expression in the development of drug resistance
... the ABC transporters in these resistance cell lines, and the corresponding gene expression was determined using real-time polymerase chain reaction (RT-PCR) to evaluate the consistency between mRNA and ...
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Evolutionary Analyses of ABC Transporters of Dictyostelium discoideum
... transmembrane transporters with related ATP- binding domains from the bacterial ...use ABC (ATP-binding cassette) transporters for both import and export, eukaryotes are thought to use them only for ...
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Control of Plasma Membrane Permeability by ABC Transporters
... of ABC transporters in directly exporting drugs from cells but also in con- trolling the composition of membranes in which they are ...and ABC transporters in general as direct drug exporters ...
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Glaucarubinone sensitizes KB cells to paclitaxel by inhibiting ABC transporters via ROS-dependent and p53-mediated activation of apoptotic signaling pathways
... treatment elicited significant apoptosis causing effect as proved by markedly clear DNA ladder formation. Loss of mitochondrial potential is a beginning stage of apoptosis. Mitochondrion is one of the chief organelles in ...
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Peroxisomal ABC transporters: functions and mechanism
... (ABC) transporters of subfamily D; (ABCD) and are activated by specific acyl CoA synthetases for further ...half transporters that homodimerize and have distinct but partially overlapping substrate ...
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