acetyl coenzyme A
Role of Acetyl Coenzyme A Synthesis and Breakdown in Alternative Carbon Source Utilization in Candida albicans
... Acetyl coenzyme A (acetyl-CoA) is the central intermediate of the pathways required to metabolize nonfer- mentable carbon ...membranes. Acetyl-CoA is trafficked in the form of acetate by the ...
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Engineering Acetyl Coenzyme A Supply: Functional Expression of a Bacterial Pyruvate Dehydrogenase Complex in the Cytosol of Saccharomyces cerevisiae
... Cytosolic acetyl coenzyme A (acetyl-CoA) is a key precursor for biosynthesis in eukaryotes and for many industrially relevant product pathways that have been introduced into Saccharomyces cerevisiae, ...
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Dynamic Metabolic Rewiring Enables Efficient Acetyl Coenzyme A Assimilation in Paracoccus denitrificans
... is acetyl coenzyme A (acetyl-CoA), which can be either oxidized in the citric acid cycle or assimilated into biomass through dedicated ...Two acetyl-CoA assimilation strategies in bacteria ...
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Protein Acetylation and Acetyl Coenzyme A Metabolism in Budding Yeast
... utilize acetyl coenzyme A (CoA) as a substrate. Acetyl-CoA is a central metabolite at the junctions of key catabolic and anabolic pathways, and its cellular level re- flects the metabolic state of ...
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Pyrophosphate Dependent ATP Formation from Acetyl Coenzyme A in Syntrophus aciditrophicus, a New Twist on ATP Formation
... from acetyl coenzyme A (CoA) and ...AMP-forming, acetyl-CoA synthetase (Acs1) for ATP synthesis from acetyl- ...high acetyl-CoA synthetase activity under all growth conditions ...from ...
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Functional Analyses of Two Acetyl Coenzyme A Synthetases in the Ascomycete Gibberella zeae
... Acetyl coenzyme A (acetyl-CoA) is a crucial metabolite for energy metabolism and biosynthetic pathways and is produced in various cellular compartments with spatial and temporal ...ACL-dependent ...
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Mitochondrial Carnitine-Dependent Acetyl Coenzyme A Transport Is Required for Normal Sexual and Asexual Development of the Ascomycete Gibberella zeae
... of acetyl coenzyme A ...several acetyl-CoA synthetic en- zymes, namely, ATP citrate lyase and acetyl-CoA synthetases (ACSs), in the plant-pathogenic fungus Gibberella ...of acetyl-CoA ...
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Regulation of Trypanosoma brucei Acetyl Coenzyme A Carboxylase by Environmental Lipids
... ABSTRACT To satisfy its fatty acid needs, the extracellular eukaryotic parasite Trypanosoma brucei relies on two mechanisms: uptake of fatty acids from the host and de novo synthesis. We hypothesized that T. brucei ...
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Role of Carnitine Acetyltransferases in Acetyl Coenzyme A Metabolism in Aspergillus nidulans
... A fundamental feature of carbon metabolism is the exis- tence of three cellular compartments—the cytoplasm, the mi- tochondria, where the tricarboxylic (TCA) cycle and respira- tion occur, and the peroxisomes, where a ...
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PanM, an Acetyl Coenzyme A Sensor Required for Maturation of l Aspartate Decarboxylase (PanD)
... and its three-dimensional structure. However, PanM failed to transfer radiolabeled acetyl moieties to its partner pro-PanD (Fig. 2). Two other lines of evidence support the conclusion that PanM is not an ...
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ATP-Citrate Lyase Is Required for Production of Cytosolic Acetyl Coenzyme A and Development in Aspergillus nidulans
... Fluoroacetate inhibition of development. High levels of flu- oroacetate in the absence of a repressing carbon source are toxic to A. nidulans. Loss-of-function mutations in the facA (ACS), facC (cytoplasmic carnitine ...
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On the methyl and carbon monoxide coupling reaction: A simulation study of acetyl coenzyme A synthase
... bipyramidal intermediate. Ultimately, migration results in the formation of an acetyl intermediate. This path is supported by structural parameters comparable to literature values. The details are new addition to ...
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Biochemical and Kinetic Characterization of the Recombinant ADP-Forming Acetyl Coenzyme A Synthetase from the Amitochondriate Protozoan Entamoeba histolytica
... colytic pathways, the E. histolytica ACD is able to function in both the acetate-forming and acetyl-CoA-forming directions of the re- action, whereas the Giardia enzyme is limited to just the acetate- forming ...
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Carnitine-Dependent Transport of Acetyl Coenzyme A in Candida albicans Is Essential for Growth on Nonfermentable Carbon Sources and Contributes to Biofilm Formation
... the acetyl-CoA is produced in the ...to acetyl-CoA, it is conceiv- able that the acetyl units must be linked to carnitine to allow their transport over the peroxisomal and mitochondrial mem- branes ...
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Variants in the 3'UTR of the ovine Acetyl-Coenzyme A Acyltransferase 2 gene are associated with dairy traits and exhibit differential allelic expression
... The acetyl-CoA acyltransferase 2 (ACAA2) gene en- codes an enzyme of the thiolase family that is involved in mitochondrial fatty acid elongation and degradation by catalyzing the last step of the respective ...
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Pioglitazone prevents cholesterol gallstone formation through the regulation of cholesterol homeostasis in guinea pigs with a lithogenic diet
... Methods: The guinea pigs were fed with the LD for 8 weeks. All guinea pigs were grouped as follows: low fat diet; LD; LD plus PIO (4 mg/kg); LD plus PIO (8 mg/kg); LD plus ezetimibe (EZE) (2 mg/kg). Gallbladder stones ...
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Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling
... ACC1: Acetyl-coenzyme A carboxylase 1; ALT: Alanine aminotransferase; AMPK: AMP-activated protein kinase; EGFP: Green fluorescent protein; FASN: Fatty acid synthase; FFA: Free fatty acid[r] ...
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Growth-dependent recombinant product formation kinetics can be reproduced through engineering of glucose transport and is prone to phenotypic heterogeneity
... that under these conditions, an unbalanced metabolic state is generated, where the rate of acetyl-coenzyme A (AcCoA) synthesis surpasses its rate of consumption by the tricarboxylic acid cycle (TCA). The ...
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Expression of cardiac insulin signalling genes and proteins in rats fed a high-sucrose diet: effect of bilberry anthocyanin extract
... ACC1: acetyl-coenzyme A carboxylase alpha; Akt: V-Akt murine thymoma viral oncogene homolog 1; AMPK: 5 ′ -AMP-activated protein kinase; BAcn: bilberry anthocyanin; Bcl2: Bcl2-like 1; CCAAT/EBP: ...
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Essential amino acid ratios and mTOR affect lipogenic gene networks and miRNA expression in bovine mammary epithelial cells
... ACACA, Acetyl-coenzyme A carboxylase alpha; ACSL1, Acyl-CoA synthetase long-chain family member 1; ACSS2, Acyl-CoA synthetase short-chain family member 2; AGPAT6, 1-acylglycerol-3-phosphate ...
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