actin polymerization
IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation
... of actin cyto- skeleton plays a crucial role ...globular actin (G-actin) and polymer- ized filamentous actin ...both actin polymerization and GluA1 insertion following ...
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Ac102 Participates in Nuclear Actin Polymerization by Modulating BV/ODV-C42 Ubiquitination during Autographa californica Multiple Nucleopolyhedrovirus Infection
... Actin polymerization factors, including NPF, Arp2/3, and actin, are predominantly located in the cytoplasm by ...nuclear actin polymerization requires these factors to accumulate in the ...
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The WASp based actin polymerization machinery is required in somatic support cells for spermatid maturation and release
... During embryonic myogenesis, D-WIP strongly localizes to sites of myoblast fusion (Berger et al., 2008; Kim et al., 2007; Massarwa et al., 2007), highlighting the cellular location where Wsp-mediated actin ...
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Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization
... Actin polymerization plays diverse roles in cell biology. Actin fibers are involved in cell division, cell signaling, cell motility and the establishment and maintenance of the cell shape [29, ...
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The Putative Pocket Protein Binding Site of Autographa californica Nucleopolyhedrovirus BV/ODV-C42 Is Required for Virus-Induced Nuclear Actin Polymerization
... nuclear actin polymerization in baculovirus-infected cells include G-actin, actin-related protein complex 2/3 (Arp2/3) (32), and a viral N-WASP-homologous protein, such as Autographa califor- ...
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Inhibition of actin polymerization decreases osteogeneic differentiation of mesenchymal stem cells through p38 MAPK pathway
... the actin cytoskeleton arrangement remained unaltered during vari- ous passages, however, within 24 hours of induction into adipocytes or osteocytes, the cells underwent significant actin cytoskeleton ...
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Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization
... active actin polymerization or elongation that occurs during junc- tion ...that actin filaments can associate with the slit diaphragm junctional complex via multiple intermediaries ...that ...
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Fasudil inhibits actin polymerization and collagen synthesis and induces apoptosis in human urethral scar fibroblasts via the Rho/ROCK pathway
... filamentous actin cytoskeleton was examined by immunofluorescence and epifluores- cence ...of actin polymerization and collagen synthesis and promotion of apoptosis were dose ...
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Koss, Hans (2012): Mechanism of actin polymerization with yeast formin Bni1p: effect of the KCI concentration on the FH2 mediated actin nucleation. Dissertation, LMU München: Medizinische Fakultät
... The term “formins” was introduced in 1990 for a group of proteins that typically contain > 1000 amino acids encoded by different transcripts of the murine limb deformity (LD) gene [40]. The FH2 (formin homology 2) ...
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mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse
... Fig. 3. TCR stimulation–dependent F-actin polymerization and subsequent peripheral F-actin ring formation at the IS are dependent on formin activity. (A) Representative dual-color TIRF images of ...
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Baculovirus AC102 Is a Nucleocapsid Protein That Is Crucial for Nuclear Actin Polymerization and Nucleocapsid Morphogenesis
... cell actin cytoskeleton during ...requires actin translocation into the nucleus early in infection and actin polymerization within the nucleus late in infection coincident with viral ...of ...
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Kaposi's Sarcoma-Associated Herpesvirus Utilizes an Actin Polymerization-Dependent Macropinocytic Pathway To Enter Human Dermal Microvascular Endothelial and Human Umbilical Vein Endothelial Cells
... the actin polymerization and formation of lamellipodial extensions that are essential for ...the actin polymerization-dependent, dynamin-independent macropinocytic pathway that involves a ...
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Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion
... et al., 1992; Hall, 1994). Rap1 effectors include guanine ex- change factors (GEFs) that activate Rac (Arthur et al., 2004). Therefore, to determine whether fluid flow activated Rac and/or Cdc42, we transfected ...
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Loss of CD73 mediated actin polymerization promotes endometrial tumor progression
... Actin polymerization in cells is balanced by actions (induc- tion of kinases, phosphatases, and actin depolymerization fac- tors) that are induced shortly afterward to keep the actin poly- ...
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Stimulated cytokineplasts from human polymorphonuclear leukocytes mobilize calcium and polymerize actin Cytoplasts made in cytochalasin B retain a defect in actin polymerization
... intracellular free calcium concentration when stimulated by chemotactic formyl peptide or by leukotriene B4, as measured by Quin-2 acetoxymethyl ester fluorescence. As in the parent cell, extracellular EGTA blunts this ...
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Modeling the neuropsychiatric manifestations of Lowe syndrome using induced pluripotent stem cells: defective F-actin polymerization and WAVE-1 expression in neuronal cells
... Background: Lowe syndrome (LS) is a rare genetic disorder caused by loss of function mutations in the X-linked gene, OCRL , which codes for inositol polyphosphate 5-phosphatase. LS is characterized by the triad of ...
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A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits
... FCHSD2 proteins used for crystallography, CryoEM, lipid binding and actin polymerization experiments were all expressed from con- structs with an N-terminal His-SUMO tag. Proteins were expressed in Rosetta ...
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Thymoquinone decreases F-actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl-XL expression
... Results: We found that TQ induces growth arrest in both MDN and XG2 cells in a dose- and time-dependent manner. TQ also inhibited CXC ligand-12 (CXCL-12)-mediated actin polymerization and cellular ...
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Local actin polymerization during endocytic carrier formation
... Conversely, Clathrin-independent endocytosis CIE forming both nanometer CLIC/GEEC, caveolae, FEME, IL2β uptake and micrometer carriers macropinocytosis are dependent on actin polymerizat[r] ...
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Apical accumulation of the Drosophila PDGF/VEGF receptor ligands provides a mechanism for triggering localized actin polymerization
... between elevated PVR levels and excess apical PVF1. As PVR overexpression leads to pupal lethality, we were able to induce lower levels of PVR by using an unusual insertion of the UAS-Pvr- RNAi construct. Although most ...
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