Activated hepatic stellate cell
HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways
... in activated hepatic stellate cell line LX2 and 5 HCC cell lines as well as one immortalized liver cell line LO2 were tested by Western blot ...in cell culture supernatant ...
15
GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation
... Our results showed that GW501516-activated PPARβ/δ enhanced phosphorylation of p38 and SAPK/JNK MAPKs without changing their expression levels. This suggested that PPARβ/δ was involved in the transcriptional ...
16
Herbal compound “Songyou Yin” attenuates hepatoma cell invasiveness and metastasis through downregulation of cytokines secreted by activated hepatic stellate cells
... Oriental herbal medicines have been used to treat ma- lignancies since ancient times [6]. Experimental studies showed that extracts from herbal medicines had antican- cer potential [7-13]. Bu-Zhong-Yi-Qi Tang, a mixture ...
9
Original Article Hepatitis B virus X protein maintains hepatic stellate cell activation by regulating peroxisome proliferator-activated receptor γ
... ic, hepatic stellate cells still have dominated the study of fibrosis [1, ...stimuli, hepatic stellate cells (HSCs) are activated, changing from a quiescent vita- min A-storing ...
8
Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling
... clonorchiasis. Cell proliferation was detected by methyl thiazolyltetrazolium (MTT) assay when LX-2 cells were incubated with 50 μg/ml of CsESPs ...of hepatic fibrosis ...cause cell death for both ...
12
Mitochondrial uncouplers inhibit hepatic stellate cell activation
... is activated and orchestrate a signalling cascade to com- pensate the reduction in ATP levels ...against cell ne- crosis and apoptosis in both human and mouse derived ...
12
Activated hepatic stellate cells promote angiogenesis via interleukin 8 in hepatocellular carcinoma
... For western blotting, proteins were separated by 10 or 15 % SDS-acrylamide gels and then transferred to 0.20 μM nitrocellulose membranes. After immunoblot- ting with an antibody against glyceraldehyde-phosphate ...
10
Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging
... Both vimentin and desmin belong to the type III inter- mediate filament protein family and play important roles in maintaining the stability of cellular structure. Besides being distributed in the cytoplasm, these ...
10
Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis
... During fibrogenesis, several ECM proteins, especially collagens type I, III, and IV; proteoglycans; laminin; and fibronectin are over-expressed by activated HSCs and other cells, which results in pathological scar ...
11
Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation
... in activated HSCs, and this action in normal physiology serves to repair injured ...inducing cell migration ...cytokines. Cell contractility is a major characteristic of HSC activation as ...well. ...
11
Role of canonical Hedgehog signaling pathway in liver
... and hepatic stellate cells express Hh ligands, and have endogenous Hh pathway ...is activated in hepatocytes and bile ductular cells ...is activated in hepatic stellate cells ...
9
<p>Activated Hepatic Stellate Cells (HSCs) Exert Immunosuppressive Effects in Hepatocellular Carcinoma by Producing Complement C3</p>
... populations or coexisting factors in the local in fl ammatory environment, which could directly or indirectly modulate C3 signaling on immune cells. In this study, the role of C3 was in accordance with that reported in ...
9
Growth inhibitory properties of endothelin 1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate mediated pathway Inhibition of both extracellular signal regulated kinase and c Jun kinase and upregulation of endothelin B receptors
... in cell prolifera- tion (26, ...predominantly activated by mitogens acting on receptor-protein tyrosine kinases or on G protein–linked receptors (26, ...are activated by stimuli that generally do not ...
9
Hepatic stellate cells: central modulators of hepatic carcinogenesis
... from activated HSC, have consistently reported increased proliferation, migration and invasion of tumour cells ...hepatoma cell lines enhanced their viability and migratory capacity ...murine ...
13
PubMedCentral-PMC5175173.pdf
... promote hepatic stellate cell ...of hepatic stellate cell ...(i.e. activated hepatic stellate ...of hepatic stellate cell activation and ...
11
Clinical significance and gene expression study of human hepatic stellate cells in HBV related-hepatocellular carcinoma
... myofibroblast-like cell activation markers, were increased significantly in activated HSCs and CAMFs compared to quiescent ...vivo activated HSCs/ CAMF suggested culture-activated HSCs can ...
10
Babao Dan attenuates hepatic fibrosis by inhibiting hepatic stellate cells activation and proliferation via TLR4 signaling pathway
... the figures indicated, BBD can obviously down-regulate the expression of TLR4 in rat livers insulted by DEN (Figure 3E). At the same time, the expression of TLR4 was also analyzed by RT-PCR and Western blot, accordingly ...
13
Molecular magnetic resonance imaging of activated hepatic stellate cells with ultrasmall superparamagnetic iron oxide targeting integrin α<sub>v</sub>β<sub>3</sub> for staging liver fibrosis in rat model
... in hepatic sinus (yellow ...in activated HSCs. Abbreviations: hsc, hepatic stellate cell; rgD, arginine-glycine-aspartic acid; TeM, transmission electron microscopy; UsPIO, ultrasmall ...
12
Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production
... that activated HSCs and Kupffer cells are the major source of TIMP-1 pro- duction as strong TIMP-1 immunostaining was detected in activated HSCs and Kupffer cells ...and hepatic levels of TIMP-1 were ...
10
The hepatic stem cell niche and paracrine signaling by mesenchymal cells in support of human hepatic stem cells
... We next analyzed the gene expression pattern of the vA + RT1A - VCAM-1 + β3- integrin + cells to examine whether they express various markers for HpSTCs. Five population were isolated by FACS, and RNAs were isolated from ...
276