activated hepatic stellate cells
Original Article Correlation between the stromal activated hepatic stellate cells and angiogenesis in human hepatocellular carcinoma
... models, activated hepatic stellate cells (HSCs) are reported to be capable of promoting tumor ...of activated HSCs on angiogenesis in human HCC is not ...between activated HSCs ...
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Herbal compound “Songyou Yin” attenuates hepatoma cell invasiveness and metastasis through downregulation of cytokines secreted by activated hepatic stellate cells
... [3]. Activated hepatic stellate cells (aHSCs) have a key role in fibrogenesis and in filtrates of the HCC stroma, where they could play a critical role in HCC ...
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Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism.
... of hepatic fibrosis is production of a large amount of extracellular matrix by activated hepatic stellate cells (HSCs), and the apoptosis of activated HSCs is a determining ...
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Activated hepatic stellate cells promote angiogenesis via interleukin 8 in hepatocellular carcinoma
... a-HSCs: activated hepatic stellate cells; CXCL-8: C-X-C motif ligand 8; CXCR 1: C-X-C motif receptor 1; HUVECs: human umbili- cal vein endothelial cells; α-SMA: α-smooth muscle actin; ...
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Original Article Molecular MRI of activated hepatic stellate cells in rats with early stage of liver fibrosis by targeting hepatic integrin α5β1
... targeting activated hepatic stellate cells (HSCs) in early stage of hepatic fibrosis rats in ...stage hepatic fibrosis model of rats was established by injecting car- bon ...
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Molecular magnetic resonance imaging of activated hepatic stellate cells with ultrasmall superparamagnetic iron oxide targeting integrin α<sub>v</sub>β<sub>3</sub> for staging liver fibrosis in rat model
... in hepatic sinus (yellow ...in activated HSCs. Abbreviations: hsc, hepatic stellate cell; rgD, arginine-glycine-aspartic acid; TeM, transmission electron microscopy; UsPIO, ultrasmall ...
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<p>Activated Hepatic Stellate Cells (HSCs) Exert Immunosuppressive Effects in Hepatocellular Carcinoma by Producing Complement C3</p>
... The complement system is the major component of both innate immunity and the acquired immune system. C3 is the central component of the complement system and promotes growth, proliferation, migration, and stemness of ...
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Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells
... of additional chromatin marks that would account for differential gene expression. We examined by chromatin immunoprecipitation (ChIP)-qPCR the profiles of H3K4me1, H3K4me3, H3K27ac and H3K27me3 [47] on upstream ...
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Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging
... transduction pathway. Integrins are the major receptors that mediate cellular adhesion and reaction to the ECM and thus play essential roles in regulating cell migration, growth, division, survival, differentiation, and ...
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Hepatic stellate cells and parasite induced liver fibrosis
... The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been well investigated over the last few years in a number of ...
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Hepatic stellate cells in liver development, regeneration, and cancer
... Hepatic stellate cells are located in the space of Disse between the sinusoidal endothelial cells and hepatic epithelial cells, and account for 5%–8% of the cells in the ...
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Hepatic stellate cells increase in Toxoplasma gondii infection in mice
... of stellate cells in liver repair as indicated by the close proximity of this cell type to collagen fibers in injured livers ...[8]. Hepatic stellate cells are known to play an ...
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HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways
... hepatoma cells, activated hepatic stellate cells, extracel- lular matrix, and their secreted or released various cytokines to regulate tumor ...These cells and matrix components ...
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PubMedCentral-PMC5175173.pdf
... promote hepatic stellate cell ...of hepatic stellate cell ...those cells could acquire myofibroblast-like characteristics and deposit collagen, which are properties of ...
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Babao Dan attenuates hepatic fibrosis by inhibiting hepatic stellate cells activation and proliferation via TLR4 signaling pathway
... aggravate hepatic fibrosis ...of hepatic stellate cells activated by LPS can be suppressed by BBD-serum in vitro by IF staining and analyzed the mRNA expression of α-SMA, collagen I and ...
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Hepatic stellate cells contribute to progenitor cells and liver regeneration
... this, stellate cells can originate from the bone marrow (BM) (10, 11), where MSCs were initially discovered (12), and reside in the liver close to endothelial cells, as is the case for MSCs in other ...
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Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis
... Kupffer cells, sinusoidal endothelial cells, bile duct epithe- lial cells, and hepatocytes [11], is a potent fibrogenic signal [20] as it increases the production of collagen I and other matrix ...
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Roles of hepatic stellate cells in liver inflammation: a new perspective
... resident cells such as Kupffer cells and HSCs are activated and, at the same time, inflammatory cells are recruited into the ...liver cells, TLR4 in particular ...Kupffer cells ...
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Hepatic stellate cells and parasite induced liver fibrosis
... positive cells in the fibrotic area of granulomas ...with hepatic fibro- sis and HSC activation as well as chemokines associated with HSC recruitment ...of activated HSC in human ...
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Hepatic stellate cells: central modulators of hepatic carcinogenesis
... from activated HSC, have consistently reported increased proliferation, migration and invasion of tumour cells ...HCC cells into nude mice promoted tumour formation and growth ...murine ...
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