activating transcription factor-3
Anti cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells
... increased activating transcription factor 3 (ATF3) expressions in both protein and mRNA level and activated ATF3 promoter activity, indicating transcriptional activation of ATF3 gene by ...
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Original Article Effect of overexpression of activating transcription factor 3 on biological behaviors of human colorectal cancer HCT116 cells
... worldwide. Activating transcription factor 3 (ATF3) has been identified as both an oncogene and a tumor sup- pressor in colorectal cancer, which encourages further studies to validate the ...
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Activating transcription factor 3 modulates protein kinase C epsilon activation in diabetic peripheral neuropathy
... whether activating transcription factor 3 (ATF3) is responsible for neuronal injury and a critical molecule that modulates the activation of intracellular protein kinase C epsilon (p-PKCε) and ...
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Contribution of Activating Transcription Factor 3 to development of acinar-to-ductal cell metaplasia
... Under physiological conditions, plasma membrane proteins travel to the ER where proper folding is facilitated by ER-resident chaperones. If the ER senses an increased demand for folding capacity, the UPR is activated ...
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Low pH results in co ordinate regulation of gene expression in oesophageal cells
... accelerating factor (DAF) was observed, which has previously been reported to be upregu- lated in BO ...The transcription factors FOSB and JUN of the AP-1 transcription complex, known to have ...
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Transcription factor ATF3 links host adaptive response to breast cancer metastasis
... identified activating transcription factor 3 (ATF3) as a molecule that regulated the host response and con- tributed to the co-option of the host by cancer cells to promote ...
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Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines
... Kruppel-like factor 6 (KLF6) [21, 22], activating transcription factor 3 (ATF3) [23], and the cyclin-dependent kinase inhibitor protein p21 [24] have been found to be reduced in ...E2F ...
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Herpesviruses and the Unfolded Protein Response
... initiation factor, eIF2α ...bZIP transcription factor Activating Transcription Factor 4 ...of transcription factors and can bind to ATF/CRE-like sequences with a consensus ...
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Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury
... [17–19]. Activating transcription factor 3 (ATF3) is one of the transcriptional factor protected inside urine exosome which expressed in urine of AKI in patients and animal models [20, ...
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Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
... (radius of 17.5 mm) filled with 500 μL of collagen gel. 1 day after seeding, 250 μL of collagen sol solution was poured on the cells and incubated for approximately 30 min at 37°C to induce gelation. The dish was then ...
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Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease
... which 3 gradient-echo scout images in axial, sagittal, and coronal directions were acquired (time to repetition/echo time = ...cm 3 , matrix size = 256 × 128 × ...
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Activating transcription factor 4 regulates osteoclast differentiation in mice
... ATF4 is upregulated by M-CSF and PI3K/AKT and is required for M-CSF induction of RANK expression in BMMs. (A and B) Effects of M-CSF on ATF4 in BMMs. Cells were cultured with or without 30 ng/ml M-CSF for the indicated ...
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Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets
... (i.e. transcription factors) or through their ...what transcription factor binding sites are present at the various regulated clusters of genes we analyzed the window from − 300 to + 50 of all ...
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Cullin-RING ligases in regulation of autophagy
... Ambra1: activating molecule in Beclin-1-regulated autophagy; AMPK: AMP-activated protein kinase; ATF4: activating transcription factor 4; ATG: autophagy related gene; Bcl-2: B-cell lymphoma 2; ...
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Dysfunction of various organelles provokes multiple cell death after quantum dot exposure
... regulate transcription of downstream genes such as Bip/ GRP78 and other cytoprotective genes, accelerating the ubiquitination of misfolded proteins through ER-assisted ...initiation factor 2 α , followed by ...
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Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells
... The ATF4-C/EBPβ complex regulates transcription of PiT1 and PiT2 genes. Since ATF4 is a pleiotropic tran- scription factor, we next proceeded to locate the ATF4 response element (ATF4RE) in the PiT1 gene ...
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Uncovering Dual Roles for PERK Signaling During Experimentally Induced Pancreatitis
... Pancreatitis is characterized by inappropriate activation of digestive enzyme precursors, or zymogens, local and systemic inflammation, dysregulation of cellular calcium (Ca 2+ ), and induction of the unfolded protein ...
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The role of death receptors in ER stress and Inflamation
... Trimerised receptor complexes have been shown to induce programmed cell death most aggressively (Hymowitz et al., 1999), inducing apoptotic signalling by facilitating a conformational change and the oligomerisation of ...
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Myxoma virus attenuates expression of activating transcription factor 4 (ATF4) which has implications for the treatment of proteasome inhibitor–resistant multiple myeloma
... dimerization and phosphorylation of IRE1, which in turn, excises 26nt from the mRNA of the transcription factor XBP1. This excision causes a frame shift in the XBP1 mRNA, allow- ing for the translation of ...
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Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans
... in 3–5-day-old larvae did not show co-expression of the glass transcript with rhabdo- meric opsin 1 (r-opsin1), which is a marker for rhabdo- meric PRs in both the dorsal and the ventral eyes [14, 16], indicating ...
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