Activating transcription factor 6 (ATF6)
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease
... the ATF6 target genes calreticulin (Mm00482936_m1), Xbp1 (Mm00457359_m1), and Chop ...used. ATF6 target genes were quan- tified by the normalized expression method using Hprt as a refer- ence with primers ...
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Developmental hypomyelination in Wolfram syndrome: new insights from neuroimaging and gene expression analyses
... radiation; ATF6: Activating transcription factor 6; BiNGO: Biological network gene ontology tool; Ca 2+ : Calcium; CC: Corpus callosum; CHD: Congenital heart disease; CNS: Central ...
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<p>KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis</p>
... and activating transcription factor 6 (ATF6), the foremost of which is the PERK-mediated PERK-eIF2 α -ATF4 ...important factor that switches the survival signal to a pro-death ...
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Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells
... and activating transcription factor 6 (ATF6) implement the ER stress response ...initiation factor 2 (eIF2α), which inhib- its assembly of the 80S ribosome and protein ...pivotal ...
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Dysfunction of various organelles provokes multiple cell death after quantum dot exposure
... ATF4, activating transcription factor 4; ATF6, activating transcription factor 6; Bak, Bcl-2 antagonist/killer 1; Bax, Bcl-2-associated X protein; Bcl-2, B-cell ...
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Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer
... Established tumors build a stressful and hostile microenvironment that blocks the development of protective innate and adaptive immune responses. Different subsets of immunoregulatory myeloid populations, including ...
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Contribution of Activating Transcription Factor 3 to development of acinar-to-ductal cell metaplasia
... Under physiological conditions, plasma membrane proteins travel to the ER where proper folding is facilitated by ER-resident chaperones. If the ER senses an increased demand for folding capacity, the UPR is activated ...
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Herpesviruses and the Unfolded Protein Response
... (PERK), Activating Transcription Factor 6 (ATF6), and Inositol-Requiring Enzyme 1 (IRE1), that are normally maintained in an inactive state by the abundant ER chaperone ...
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Endoplasmic reticulum stress and apoptosis
... used: ATF6 – activating transcription factor 6; BAP31 – B-cell receptor- associated protein 31; BiP – luminal binding protein; C/EBP – CCAAT/enhancer- binding proteins; eIF-2α – ...
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Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
... Cancer cells that survive after irradiation acquire malignant phenotypes [2–5]. We previously reported that P cells that survive after irradiation (IR cells) are more invasive than non-irradiated P cells [6–8]. ...
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Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines
... Kruppel‑like factor 6 (KLF6), activating transcription factor 3 (ATF3) and p21, while down‑regulating the expression of selected oncogenes, including E2F transcription ...
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Cullin-RING ligases in regulation of autophagy
... Ambra1: activating molecule in Beclin-1-regulated autophagy; AMPK: AMP-activated protein kinase; ATF4: activating transcription factor 4; ATG: autophagy related gene; Bcl-2: B-cell lymphoma 2; ...
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Low pH results in co ordinate regulation of gene expression in oesophageal cells
... accelerating factor (DAF) was observed, which has previously been reported to be upregu- lated in BO ...The transcription factors FOSB and JUN of the AP-1 transcription complex, known to have ...
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The HLA B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients
... ATF4: activating transcription factor 4; BiP/ GRP78: glucose regulated protein; C1QC/C1QB: complement component 1, q subcomponent, C / B chain; CDKN1A: Cyclin-dependent kinase inhibitor 1; EC: ...
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Immune cell subset differentiation and tissue inflammation
... of transcription; STEAMI: ST-elevation acute myocardial infarction; STEMI: ST segment elevation myocardial infarction; T(EM): Effector memory T cell; T1DM: Type 1 diabetes mellitus; T2DM: Type 2 diabetes mellitus; ...
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Activating transcription factor 4 regulates osteoclast differentiation in mice
... Using biochemical, cellular, and genetic approaches, the present study demonstrates that ATF4 is an osteoclastic transcription fac- tor, which we believe to be novel, that is essential for OCL differentiation. We ...
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E1A mediated activation of the adenovirus E4 promoter
... Although the transient expression assay is an extremely useful tool for defining the activity of a particular promoter, it does not necessarily truly reflect the activity of the promoter in its natural context, whether a ...
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Li, He (2017): APC/C independent function of the spindle assembly checkpoint. Dissertation, LMU München: Fakultät für Biologie
... the transcription factors Mcm1 and Fkh2 (Althoefer et ...transcriptional factor Mcm1 is required for the cell cycle-regulated periodicity of these genes and forms a ternary complex with Fkh2 on the upstream ...
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Palmitate-induced Slc2a4/GLUT4 downregulation in L6 muscle cells: evidence of inflammatory and endoplasmic reticulum stress involvement
... beta-actin); ATF6: Cyclic AMP-dependent transcription factor (indiscriminate subunit); DDIT-3: DNA damage-inducible transcript 3 protein (former growth arrest and DNA damage-inducible protein 153, ...
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Identification potential biomarkers in pulmonary tuberculosis and latent infection based on bioinformatics analysis
... infection [3]. With aging or immune system deteriorat- ing, M. tuberculosis can reactivate and cause severe pul- monary TB [4]. Roughly 10 % of the latent infections can progress to active TB. The general signs and symp- ...
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