Activating transcription factor (ATF3)
The induction of activating transcription factor 3 (ATF3) contributes to anti cancer activity of Abeliophyllum distichum Nakai in human colorectal cancer cells
... of activating transcription factor 3 (ATF3) has been known to exert a proapoptotic effect in human colorectal cancer [8-10] and ATF3 is a major target of some anticancer drugs including ...
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Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells
... and activating transcription factor 6 (ATF6) implement the ER stress response ...initiation factor 2 (eIF2α), which inhib- its assembly of the 80S ribosome and protein ...pivotal ...
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Activating transcription factor 4 regulates osteoclast differentiation in mice
... Activating transcription factor 4 (ATF4) is a critical transcription factor for osteoblast (OBL) function and bone formation; however, a direct role in osteoclasts (OCLs) has not been ...
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Myxoma virus attenuates expression of activating transcription factor 4 (ATF4) which has implications for the treatment of proteasome inhibitor–resistant multiple myeloma
... aTF, activating transcription factor; Brea, brefeldin-a; cDna, complementary Dna; MOi, multiplicity of infection; mrna, messenger rna; MYXV, myxoma virus; qPcr, quantitative real-time polymerase ...
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Contribution of Activating Transcription Factor 3 to development of acinar-to-ductal cell metaplasia
... Under physiological conditions, plasma membrane proteins travel to the ER where proper folding is facilitated by ER-resident chaperones. If the ER senses an increased demand for folding capacity, the UPR is activated ...
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Anti cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells
... USA). ATF3 antibody and ATF3 siRNA were provided from Santa Cruz Biotechnology, Inc (Santa Cruz, CA, ...USA). ATF3 promoter con- structs (-1420/+34, -718/+34, -514/+34, -318/+34, -147/+34 and ...
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The Biology and Regulation of Activating Transcription Factor 3 (ATF3) by Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and Dietary Compounds with Chemopreventive Activity.
... regarding ATF3 in colorectal cancer ...cells, ATF3 is induced by ionizing radiation by a p53-dependent mechanism, and that this effect did not occur in RKO-E6 (etoposide resistant) cells ...Furthermore, ...
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Transcription factor ATF3 links host adaptive response to breast cancer metastasis
... identified activating transcription factor 3 (ATF3) as a molecule that regulated the host response and con- tributed to the co-option of the host by cancer cells to promote ...metastasis. ...
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<p>KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis</p>
... and activating transcription factor 6 (ATF6), the foremost of which is the PERK-mediated PERK-eIF2 α -ATF4 ...important factor that switches the survival signal to a pro-death ...
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Low pH results in co ordinate regulation of gene expression in oesophageal cells
... accelerating factor (DAF) was observed, which has previously been reported to be upregu- lated in BO ...The transcription factors FOSB and JUN of the AP-1 transcription complex, known to have ...
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Uncovering Dual Roles for PERK Signaling During Experimentally Induced Pancreatitis
... members Activating Transcription Factor (ATF) 3 and stanniocalcin (STC) ...of ATF3 and STC2 within the context of PERK signaling and pancreatitis are not well ...and ATF3 during ...
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Herpesviruses and the Unfolded Protein Response
... initiation factor, eIF2α ...bZIP transcription factor Activating Transcription Factor 4 ...of transcription factors and can bind to ATF/CRE-like sequences with a consensus ...
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Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines
... Kruppel-like factor 6 (KLF6) [21, 22], activating transcription factor 3 (ATF3) [23], and the cyclin-dependent kinase inhibitor protein p21 [24] have been found to be reduced in ...
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Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
... overexpression of the genes, we used Lipofectamine 2000 reagent (Invitrogen, Carlsbad, CA). The cells were cultured in Dulbecco’s modified Eagle medium (DMEM; Sigma, St Louis, MO) containing 10% fetal bovine serum ...
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Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury
... [17–19]. Activating transcription factor 3 (ATF3) is one of the transcriptional factor protected inside urine exosome which expressed in urine of AKI in patients and animal models [20, ...
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Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease
... Coupled Transcription/Translation, Promega) Nt-ATF6 (aa 1–376) was added to the beads, as well as repa- glinide (400 nM) as indicated, and incubated (1 hour, with rotation at ...
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Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets
... (i.e. transcription factors) or through their ...what transcription factor binding sites are present at the various regulated clusters of genes we analyzed the window from − 300 to + 50 of all ...
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Cullin-RING ligases in regulation of autophagy
... Ambra1: activating molecule in Beclin-1-regulated autophagy; AMPK: AMP-activated protein kinase; ATF4: activating transcription factor 4; ATG: autophagy related gene; Bcl-2: B-cell lymphoma 2; ...
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Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer
... Established tumors build a stressful and hostile microenvironment that blocks the development of protective innate and adaptive immune responses. Different subsets of immunoregulatory myeloid populations, including ...
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The HLA B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients
... The study subjects (lcSSc with PAH and without PAH), as well as healthy controls (HC) were stratified for the pres- ence of HLA-B*35 allele (18 % of the HCs and 27 % of the lcSSc were B35-positive, of those 27 % of PAH ...
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