activator protein-1
Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease
... Activator protein 1 (AP-1) (Fos/Jun) is a transcriptional regulator composed of members of the Fos and Jun families of DNA binding proteins. The functions of AP-1 were initially studied ...
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Expression of activator protein 1 in papillary thyroid carcinoma and its clinical significance
... In many tumors, the oncogene Ras continuously acti- vates and phosphorylates JNK through the MAPK signal- ing pathway. Activation of the transcription factor AP-1 upregulates the expression of MMP-9 and VEGF and ...
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Activator protein 1 (AP 1) contributes to EpCAM dependent breast cancer invasion
... role of c-myc in regulating genes involved in control of the cell cycle. However, we and others have found that the most dramatic phenotype associated with manipula- tion of EpCAM expression in human cancers is altered ...
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Molecular regulation of the expression of leptin by hypoxia in human coronary artery smooth muscle cells
... and protein levels increased after ...leptin/activator protein 1 (AP-1) binding and transcriptional activity to the leptin promoter increased after hypoxia, and SP600125, JNK siRNA, ...
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Role of AP-1 transcriptional factor in development of oxidative and nitrosative stress in periodontal tissues during systemic inflammatory response
... as activator protein 1 (AP-1) in the development of oxidative and nitrosa - tive stress in soft periodontal tissues during chronic systemic inflammatory response ...
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Myostatin gene promoter: structure, conservation and importance as a target for muscle modulation
... AP-1: Activator protein 1; ARE: Androgen receptor element; C/EBP α : CCAAT/enhancer-binding protein- α ; ChoRE: Carbohydrate responsive element; ChREBP: Carbohydrate responsive element ...
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Genomic effects of the vitamin D receptor: Potentially the link between vitamin D, immune cells, and multiple sclerosis
... AP-1, activator protein 1; ATAC-seq, assay for transposase-acces- sible chromatin using sequencing; C/EBP, CCAAT/enhancer-binding protein; ChIA-PET, chromatin interaction analysis by ...
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Investigation of the regulation of Bcl 2 family members in apoptosis and cancer
... A1 Bcl-2 related protein-A1 AIDS Acquired immune deficiency syndrome AMPK Adenosine monophosphate-activated protein kinase AP1 Activator protein 1 Apaf-1 Apoptotic protease activating fa[r] ...
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Regulation of bone by the adaptive immune system in arthritis
... AP-1, activator protein 1; CNS2, conserved noncoding sequence 2; CREB, cyclic adenosine monophosphate responsive-element-binding protein; EAE, experimental autoimmune encephalomyelitis; ...
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Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis
... Figure 2 Paclitaxel-induced inflammation is mediated by upregulation of IL-8 via NFkB signaling. In some cancers, paclitaxel has been shown to activate ERK through Toll- like receptor 4 (TLR4)-myeloid differentiation ...
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How dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome
... AP-1, activator protein 1; APP, amyloid beta (A4) precursor protein; bHLH, basic helix-loop helix; BMP2, bone morphogenetic protein 2; bZIP, basic region- leucine zipper; CDK, ...
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Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering
... ANXA 1: Annexin 1 protein; AP-1: Activator protein 1; ASA: Aspirin; ATLs: Stable aspirin-triggered lipoxin; COX: Cyclo-oygenase; CRP: High sensitive-C- Reactive ...
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RETRACTED ARTICLE: Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
... serine/threonine-specific protein kinase; AP-1: Activator protein 1; Bcl- 2: B-cell lymphoma 2; BRD4: Bromodomain-containing protein 4; CADM1: Cell adhesion molecule 1; ...
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Molecular mechanisms of HPV mediated neoplastic progression
... AP-1: Activator protein 1; ATM: Ataxia telangiectasia mutated; ATR: Ataxia telangiectasia and Rad3-related protein; Bax: BCL2-associated X protein; BRCA1: Breast cancer type1; ...
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Role of TERRA in the Regulation of Telomere Length
... mere-specific protein complex, shelterin. The shelterin complex consists of six protein subunits: telomeric repeat binding factor-1 (TRF1), TRF2, re- pressor/activator protein-1 ...
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Wip1 and p53 contribute to HTLV 1 Tax induced tumorigenesis
... due to variances in the mouse numbers, the mouse strains, and the criteria used to determine tumor-free survival and when euthanasias of mice are performed. To date, in the published literature, only cross-sectional ...
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Sophorae Flos extract inhibits RANKL induced osteoclast differentiation by suppressing the NF κB/NFATc1 pathway in mouse bone marrow cells
... The protein concen- tration in the supernatants was determined using the Bradford method ...[24]. Protein samples (30 μg) were separated in sodium dodecyl sulfate-polyacrylamide gels and transferred to ...
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Searching for transcriptional regulators of Ang II–induced vascular pathology
... transcriptional activation and gene expression, but the mechanisms explaining its long-term tissue effects in vivo are relatively unknown. Do the multiple in vivo vascular activities elicited by Ang II (such as ...
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Expression of deleted in liver cancer 1 and plasminogen activator inhibitor 1 protein in ovarian carcinoma and their clinical significance
... Plasminogen activator inhibitor 1 (PAI-1) is the key inhibitor of the plasminogen activation system (PAS), PAI-1 participate in the pathophysiology of a num- ber of diseases such as ...
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Discovery of Compound A – a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity
... Gcs remain a gold standard as anti-inflammatory drugs. They are effective against a wide range of inflammatory and autoimmune diseases characterized by the different types of CD4+ T helper (Th) lymphocytes. Th1 cells ...
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