activin receptor
A Soluble Activin Receptor Type IIB Does Not Improve Blood Glucose in Streptozotocin-Treated Mice
... Type 1 diabetes mellitus (T1DM), or insulin dependent DM, is accompanied by decreased muscle mass. The growth factor myostatin (MSTN) is a negative regulator of muscle growth, and a loss of MSTN signaling has been shown ...
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Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants
... of activin in pancreatic rudiments of rat embryos and stimulation of insulin secretion from adult rat pancreatic islets by activin, activin is implicated in the de- velopment and function of ...of ...
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MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11
... The other potential target of miR-98, ALK4, is known to mediate the functions of several members of the TGF-b superfamily. Presently, there is limited evidence indicating that ALK4 plays a role in tumorigenesis. ...
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Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.
... of activin-A for 12 ...between activin and follistatin, cells were treated with activin-A (10 ng/ml) alone, or activin-A with different concentrations of follistatin-288 (10, 20, 50, or 100 ...
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Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP response elements
... transmembrane receptor with kinase activity, the two ways Baboon can function are by post-translational modification of substrates, or by binding and regulating the activity of other proteins ...Drosophila ...
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Treatment with soluble activin type IIB receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy
... the activin/myostatin pathway has recently emerged as a potential therapeutic approach for the treatment of ...via activin type IIA or type IIB receptors ...of activin receptor ligands leads ...
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Interplay between activin and Hox genes determines the formation of the kidney morphogenetic field
... that activin, a secreted morphogen, is necessary but insufficient for Lim1 induction and establishment of the kidney ...field. Activin or activin-like and BMP signaling cascades are activated along ...
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Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling
... soluble activin receptor type IIB (sActRIIB) (increase of 30–62 % compared with untreated ...the activin ligand trap protected against the development of liver abnormalities including polyploidy ( 18 ...
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Activin/Nodal signalling in stem cells
... which Activin signalling has a specific role in maintaining cell ‘ stemness ’ , whereas the function of TGF β seems to be less ...β receptor II in mouse skin epithelium does not induce large changes during ...
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Drosophila Activin β and the Activin like product Dawdle function redundantly to regulate proliferation in the larval brain
... Drosophila Activin-like ligands Activin-  and Dawdle control several aspects of neuronal morphogenesis, including mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon ...the ...
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Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
... by Activin/Nodal signalling in hESCs, we compared the gene expression profile of hESCs grown in chemically defined medium (CDM) containing Activin with that of hESCs grown for two days in CDM without ...
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Activin redux: specification of mesodermal pattern in Xenopus by graded concentrations of endogenous activin B
... with activin function Our experiments do not represent the first attempt to investigate the role of activin in Xenopus development, but they may use the most specific tool to inhibit activin ...
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Muscle growth in teleost fish is regulated by factors utilizing the activin II B receptor
... including activin A and myostatin, which signal through the activin type I and type II serine/threonine kinase receptors (Link and Nishi, 1997; Lee et ...the activin type II receptors (A and B) are ...
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Activin A increases phagocytosis of Escherichia coli K1 by primary murine microglial cells activated by toll-like receptor agonists
... macrophages, activin A inhibited the phagocytic activity of LPS-activated macrophages [40, 41, ...of activin A treatment: In our experiment, activin A treatment of micro- glial cells started 24 h ...
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Activin B can signal through both ALK4 and ALK7 in gonadotrope cells
... I receptor used by the activins. Recently, however, activin B and activin AB where shown to signal through ALK7 in a murine pancre- atic β cell line ...this receptor can broker activin ...
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Activin A directs striatal projection neuron differentiation of human pluripotent stem cells
... in activin-treated ...in activin-treated cultures (Fig. 3B; data not shown). Moreover, activin stimulation resulted in an increase in the levels of GAD1 , which encodes one of several forms of ...
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Activin like signaling activates Notch signaling during mesodermal induction
... because activin A predominantly induces the same range of tissues in animal ...where activin-like signaling induces ...the activin-like signaling and Notch signaling path- ways interact at the stage ...
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Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination
... In the embryonic CNS, development of myelin-forming oligodendrocytes is limited by bone morphogenetic proteins, which constitute one arm of the transforming growth factor- β (Tgf β ) family and signal canonically via ...
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Novel functions of Noggin proteins: inhibition of Activin/Nodal and Wnt signaling
... BMP receptor alone is unable to rescue the effects of Noggin2 ...of Activin and ...stages, Activin/Nodal signaling must be inhibited, together with BMP and Wnt signaling, in the anterior region of ...
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Differential regulation of follicle stimulating hormone by activin A and TGFB1 in murine gonadotropes
... latter receptor complexes can stimulate Smad1/5 phosphoryla- tion and thereby inhibit TGFB1 actions mediated via TGFBR1 and Smad2/3 ...endogenous activin B-dependent signaling (via Smad2/3) and hence ...
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