activin receptor-like kinase
MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11
... To elucidate the mechanism of the observed miR-98 effects, we utilized computational approaches to identify putative binding sites for miR-98. MiR-98 binding sites were identified in various mRNAs, many of which were ...
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Follistatin is a metastasis suppressor in a mouse model of HER2 positive breast cancer
... factor receptor 2, receptor tyrosine protein kinase erbB-2, proto-oncogene Neu )-induced metastatic breast cancer, we previously reported that activin receptor-like kinase ...
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Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
... protein receptor II (BMPRII) [2], activin receptor-like kinase-1 (ALK-1) [3] and recent discovery of dysregulated genes encoding for hypoxia inducible factor 3-alpha (HIF-3 alpha), ...
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Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative
... affected sites include the nasal, mucocutaneous, gastrointesti- nal, pulmonary, cerebral, and hepatic vascular beds. Most pa- tients have frequent nose bleeds by age 21 and skin telangi- ectases by age 40, and a ...
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Hemodynamic and genetic analysis in children with idiopathic, heritable, and congenital heart disease associated pulmonary arterial hypertension
... II receptor (BMPR2) gene, 2 Activin A receptor type II-like kinase-1 (ACVRL1) mutations and one Endoglin (ENG) mutation were found in the 29 I/HPAH ...
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The complex regulation of TGF-ß in cardiovascular disease
... to receptor type 2 and phosphorylates the type 1 receptor, whose main isoform is termed ALK-4 (activin-like ...This kinase phosphorylates and activates Smad2 or Smad3, which forms a ...
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Molecular networks in skeletal muscle plasticity
... ActRIIA/B, activin receptor protein II; Akt, protein kinase B; AMP, adenosine mono-phosphate; AMPK, AMP-activated protein kinase; BMP, bone morphogenic protein; DGK, diacylglycerol ...
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Regulation of TGF-β receptor activity
... , activin, Nodal, bone morphogenetic proteins (BMPs) and others, play vital roles in development, tissue homeostasis and some diseases development ...threonine kinase receptors, the type II (TbRII) and type ...
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Modulation of cerebral endothelial cell function by TGF-β in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition
... TGF-β receptor (TβR) II / activin-like kinase (ALK)-5-dependent manner under normoxia and hypoxia, defining potential indirect proangiogenic activity of TGF-β in ...
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Genetic analyses in a cohort of 191 pulmonary arterial hypertension patients
... protein receptor type 2) [19], KCNK3 (potassium two pore domain chan- nel subfamily K member 3) [13], CAV1 (caveolin 1) [14], SMAD9 (SMAD family member 9) [15], BMPR1B (bone morphogenetic protein receptor ...
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Smad dependent mechanisms of inflammatory bone destruction
... the receptor-regulated Smads (R-Smad), the common-mediator Smads (Co-Smads) and the inhibitory Smads (I-Smads) [26, ...I receptor kinase while BMPs phosphorylate and activate R-Smad1/5/ 8 [27, ...
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Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor
... ATP was combined to start the reaction. Reactions were carried out at 25°C for 120 minutes. The reaction mixtures were then spotted onto P81 ion-exchange filter paper. The dry filters were then washed in 0.75% phosphoric ...
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New developments in the treatment of HER2-positive breast cancer
... (closed) kinase conformation, compared with reversible EGFR TKIs gefitinib and erlotinib, which can bind EGFR in the active (open) or inactive ...the kinase to revert to the open ...
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Low-intensity pulsed ultrasound prevents muscle atrophy induced by type 1 diabetes in rats
... Protein kinase B (Akt), a serine/threonine kinase, is recruited to the membrane by an interaction with phos- phoinositide docking sites for full activation ...
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Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.
... of activin-A for 12 ...between activin and follistatin, cells were treated with activin-A (10 ng/ml) alone, or activin-A with different concentrations of follistatin-288 (10, 20, 50, or 100 ...
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Deficiency in neuronal TGF β signaling promotes neurodegeneration and Alzheimer’s pathology
... I receptor kinase inhibitor, both of which cause neurode- generation, increased the levels of Aβ in cell culture supernatant (Figure 5, A and ...in activin and nodal signaling ...
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Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass
... myostatin receptor (AcvR2B), leading to phosphorylation of Smad2 and Smad3, which then form a heterodimer with Smad4 to translocate to the nucleus to regulate gene transcrip- ...myostatin receptor along ...
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The EVERSHED receptor like kinase modulates floral organ shedding in Arabidopsis
... repeat receptor-like kinase, EVERSHED (EVR), that functions as an inhibitor of ...HAESA/HAESA-LIKE2 receptor-like kinases, indicating that this signaling pathway may be constitutively ...
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RPK2 is an essential receptor like kinase that transmits the CLV3 signal in Arabidopsis
... remaining receptor(s) in the single and double mutants might functions to over-activate CLV3 expression via increased WUS expression ...the receptor(s). The rpk2 mutant exhibits the weaker clv-like ...
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Human resistin and the RELM of Inflammation in diabesity
... Lately, implications for resistin as a biomarker in cancer and potential area for therapeutic intervention have been drawn. Numerous studies have reported elevated levels of resistin in certain forms of cancer, such as ...
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