acyl carrier protein
Discrimination of Potent Inhibitors of Toxoplasma gondii Enoyl-Acyl Carrier Protein Reductase by a Thermal Shift Assay
... Enoyl-Acyl Carrier Protein Reductase (ENR) is an essential FASII pathway enzyme and the target of a number of antimicrobial drug discovery ...
28
The Two Functional Enoyl Acyl Carrier Protein Reductases of Enterococcus faecalis Do Not Mediate Triclosan Resistance
... Enoyl-acyl carrier protein (enoyl-ACP) re- ductases (ENRs) reduce trans-2-enoyl-ACPs to the fully saturated ACP species in the last step of the elongation cycle in the synthesis of bacterial and ...
10
Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents
... Enoyl acyl carrier protein reductase (ENR) carries out one of two reductive steps in the type II FAS pathway and has been shown to be the target of several families of antimicrobial compounds, ...
11
Screening of Annona muricata for E coli enoyl acyl carrier protein reductase inhibitors by molecular docking
... against various cancers without affecting the normal cells [8]. Ethanolic extract of A. muricata leaves was proven to exhibit apoptosis inducing potential against myelogenous leukemic K562 cells [9-10]. Constituents ...
6
Novel Xanthomonas campestris Long Chain Specific 3 Oxoacyl Acyl Carrier Protein Reductase Involved in Diffusible Signal Factor Synthesis
... 3-hydroxyacyl-acyl carrier protein (3- hydroxyacyl-ACP) thioesters having acyl chains of 12 to 13 carbon atoms produced by the fatty acid biosynthetic ...harveyi acyl-ACP synthe- tase ...
11
Depletion of Mitochondrial Acyl Carrier Protein in Bloodstream-Form Trypanosoma brucei Causes a Kinetoplast Segregation Defect
... phospholipids. Acyl carrier protein (ACP), a key player in this pathway, forms a thioester linkage to the growing fatty acyl group and shuttles this molecule between the four enzymes ...
7
3-D QSAR CoMFA Models of Pyrrolidine carboxamides for Prediction of Enoyl acyl carrier protein reductase Inhibitory Activity
... The predictive 3D-QSAR models were generated for the training sets of Enoyl acyl carrier protein reductase inhibitors using default parameters of COMFA, as determined by cross validation. Reliability ...
17
ACYL-ACYL CARRIER PROTEIN DESATURASE2 and 3 are responsible for making omega-7 fatty acids in the Arabidopsis aleurone
... Omega-7 monounsaturated fatty acids (v-7s) are specifically enriched in the aleurone of Arabidopsis (Arabidopsis thaliana) seeds. We found significant natural variation in seed v-7 content and used a Multiparent Advanced ...
10
Improving hydrocarbon production by engineering cyanobacterial acyl-(acyl carrier protein) reductase
... Background: Acyl-(acyl carrier protein (ACP)) reductase (AAR) is a key enzyme for hydrocarbon biosynthesis in cyanobacteria, reducing fatty acyl-ACPs to aldehydes, which are then ...
13
DESIGN, SYNTHESIS, AND DOCKING OF SULFADIAZINE SCHIFF BASE SCAFFOLD FOR THEIR POTENTIAL CLAIM AS INHA ENOYL (ACYL CARRIER PROTEIN) REDUCTASE INHIBITORS
... Keeping this point discussed in above paragraph, and based on previously reported research work [21], we have decided to combine the two pharmacophores for testing their antimycobacterial activity, namely, sulfadiazine ...
5
Enterococcus faecalis Encodes an Atypical Auxiliary Acyl Carrier Protein Required for Efficient Regulation of Fatty Acid Synthesis by Exogenous Fatty Acids
... the protein level ...the protein data obtained in three biological repeats of the experiments, the levels of acpA transcripts were markedly decreased in oleate-grown cultures whereas those of acpB ...
16
An approach to the semisynthesis of acyl carrier protein : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Chemistry at Massey University
... a n sem1 s yn t 1e s1s ave een s ugge s te ·or t1e prepar- a t ion of a n a l ogues of a protein . Th e s e methods involve the synth es i s of a prote i n i n the form of a numbe r of sma l l pep- tide s , e ach ...
142
Arabidopsis acyl-acyl carrier protein synthetase AAE15 with medium chain fatty acid specificity is functional in cyanobacteria
... the acyl activating enzyme AAE15 of Arabidopsis encoded by At4g14070, which is a homologue of a cyanobacterial acyl-ACP synthetase ...Keywords: Acyl-ACP synthetase, Medium chain fatty acids, ...
9
Engineering acyl carrier protein to enhance production of shortened fatty acids
... acyl chain lengths. Specifically, expressing certain mutant ACPs enhanced the level of C14 fatty acids in membrane lipids, and by co-expressing mutant ACPs with a chain- length specific thioesterase production of ...
7
Comparison of aldehyde-producing activities of cyanobacterial acyl-(acyl carrier protein) reductases
... It is known that AAR proteins are prone to aggregation, and the 73102 AAR protein forms inclusion bodies when overexpressed in E. coli [19]; this situation precludes in vitro characterization of the catalytic ...
15
IN SILICO DESIGN, DOCKING, SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2,5 DISUBSTITUTED 1,3,4 OXADIAZOLE DERIVATIVES
... β-ketoacyl-acyl carrier protein synthase III (FabH), which is the enzyme responsible for the first reaction in the pathway and plays an important regulatory ...
9
Effects of Enoyl-Acyl Protein Carrier Reductase Mutations on Physiochemical Interactions with Isoniazid: Molecular Dynamics Simulation
... The resistance strains of Mycobacterium tuberculosis have complicated the tuberculosis management and therapy. Prior to the discovery of a more effective therapy, it is crucial to understand the molecular basis and ...
16
IDENTIFICATION OF NEW COMPOUNDS AGAINST ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS
... The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an enzyme involved in the type II fatty acid biosynthesis pathway of M. ...
9
In silico target fishing and pharmacological profiling for the isoquinoline alkaloids of Macleaya cordata (Bo Luo Hui)
... enoyl-acyl carrier reductase PfENR* fished by two alkaloids (C5 and C26) and the (3R)-hydroxymyristoyl acyl carrier protein dehydratase FabZ* in silico targeted by six alkaloids (C5, ...
20
Insulin receptor membrane retention by a traceable chimeric mutant
... the acyl carrier protein (ACP) syntase (ACP-S) which transfers a 4’-phosphopantetheine group from the Coenzyme A (CoA) to a conserved serine inside the A1 ...
13