Acyl-CoA synthetase
ab Acyl-CoA Synthetase Assay Kit (Fluorometric)
... ab273315 Acyl-CoA Synthetase Assay Kit (Fluorometric) 6 8. Technical Hints This kit is sold based on number of tests. A “test” simply refers to a single assay well. The number of wells that contain ...
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The Maize High-Lysine Mutant opaque7 Is Defective in an Acyl-CoA Synthetase-Like Protein
... The putative o7-ref allele has a 12-bp in-frame deletion of codons 350 – 353 in a 528-codon-long acyl-CoA synthetase-like gene (ACS). We then con fi rmed this candidate gene by generating another ...
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The effect of acyl-CoA synthetase long-chain family member 5 on triglyceride synthesis in bovine preadipocytes
... Abstract. Acyl-CoA synthetase long-chain family member 5 (ACSL5) is a member of the acyl coenzyme A (CoA) long-chain synthase families (ACSLs), and it plays a key role in fatty acid ...
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Structural Basis of the Substrate-specific Two-step Catalysis of Long Chain Fatty Acyl-CoA Synthetase Dimer* □S
... fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regu- lation of cellular functions via the production of long chain fatty acyl-CoA ...fatty ...
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Acyl-CoA synthetase 1 exacerbates lipotoxic inflammasome activation. in primary macrophages
... with CoA and therefore contributes to “activating” FAs for a variety of downstream cellular pathways including ceramide synthesis, phospholipid generation, FAO, and/or triglyceride ...
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Acyl-CoA synthetase isoform 1 deficiency impairs beta-oxidation in mouse heart and adipose tissue
... of acyl- CoAs that are used for β-oxidation. If all acyl-CoAs were metabolically equivalent, one would expect that the rates of acyl-CoA incorporation into all metabolic end products would be ...
184
Improved Characterization of Polyunsaturated Fatty Acids Desaturases and Elongases by Co-Expression in Saccharomyces cerevisiae with a Protozoan Acyl-CoA Synthetase
... substrates. Acyl-CoA synthetases (ACS) are involved in fatty acids uptake, and catalyze the synthesis of the corresponding CoA ...elongases, acyl-CoA desaturases and acyl ...for ...
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Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis
... Our results suggest that the catalytic activity is required for the vulnerability to ACSL3 depletion in mutant KRAS NSCLC. However, we were unable to rescue the viability defect caused by ACSL3 suppression with ...
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A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction.
... (3:1:1 ACN, IPA: Methanol). The internal standard was 20 ng/ml of C17-CoA. The samples were sonicated on ice, followed by centri- fugation at 4 C. Clean extract was recovered and dried under a gentle stream of ...
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Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer
... determined by doxycycline inhibition of ACSL4 expression in MCF-7 Tet-Off/ACSL4 cells, by the expression of ACSL4 in the non-aggressive T47D breast cancer cell line and by knocking dow[r] ...
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Functions of rat acyl-CoA synthetases in bacteria and mammalian cells
... chain acyl-CoA synthetases ...The acyl-CoA synthetase activity of FATP and ACSL may contribute to LCFA uptake by trapping LCFA in the form of LC-CoA upon ...provide ...
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Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy.
... R.A. Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited ...localized acyl-CoA synthetase 4 isoenzymes ...
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Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors
... metabolic acyl-CoAs are capable of inhibiting KAT-catalyzed acetylation with some degree of ...metabolic acyl-CoAs, thereby producing endogenous KAT bisubstrate inhibitors in ...to CoA analogs via ...
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Effect of Cheonggukjang supplementation upon hepatic acyl-CoA synthase, carnitine palmitoyltransferase I, acyl-CoA oxidase and uncoupling protein 2 mRNA levels in C57BL/6J mice fed with high fat diet
... 19. Slavin JL, Karr SC, Hutchins AM, Lampe JW (1998) Influence of soybean processing, habitual diet and soy dose on urinary isofl- avonoid excretion. Am J Clin Nutr 68: S1492–S1495 20. Suzuki H, Kawarabaysi Y, Kondo J, ...
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Mycobacterial Acyl-CoA Corboxylases.
... 4.4. Discussion To date, mycobacterial mutant strains defective in acyl-CoA carboxylase have not been isolated. Detrimental effects of the accBC? deletion in M. bovis BCG making impossible for the mutant to ...
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Structure of p300 in complex with acyl-coa variants
... diverse acyl-CoA cofactors in the active site in a conformation that is compatible with the binding of protein substrates and transfer of the acyl moiety, we have systematically analyzed ...
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Structural and Functional Studies on Acyl-CoA Carboxylases of Mycobacterium tuberculosis
... Zusammenfassung Mycobacterium tuberculosis ist der Tuberkuloseerreger, dem jährlich zwei Millionen Menschen zum Opfer fallen und der jedes Jahr viele Millionen Neuinfektionen aufweist. Die Zellwand von M. tuberculosis ...
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Structural and Kinetic studies of Acyl-CoA Carboxylases in Mycobacterium tuberculosis
... The requirement of mycolic acids for the growth, survival and antibiotic resistance of Mycobacteria means the enzymes involved in mycolic acid synthesis are attractive potential drug targets. Acyl-CoA ...
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Arabidopsis acyl-acyl carrier protein synthetase AAE15 with medium chain fatty acid specificity is functional in cyanobacteria
... Danuta Kaczmarzyk 1,2 , Elton P. Hudson 2 and Martin Fulda 1* Abstract Cyanobacteria are potential hosts for the biosynthesis of oleochemical compounds. The metabolic precursors for such compounds are fatty acids and ...
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The fatty acyl-CoA reductase Waterproof mediates airway clearance in Drosophila
... fatty acyl-CoA reductase (FAR), is essential for the gas filling of the tracheal tubes during Drosophila embryogenesis, and does not affect branch network formation or key tracheal maturation ...
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