Adaptive Resistance
Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
... expression in T cells was predominantly found on the therapeutic PD-1 antibody-bound subset, (2) upregulation of TIM-3 was only detected in tumour-bearing lungs but not in sentinel lymph nodes and peripheral blood, (3) ...
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Hetero- and adaptive resistance to polymyxin B in OXA-23-producing carbapenem-resistant Acinetobacter baumannii isolates
... Our study for the first time investigated the presence of hetero- and adaptive resistance to polymyxin B in unrelated OXA-23-producing CRAB isolates. Additionally, the stability of these phenomena was ...
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Antimicrobial efficacy of novel titanium dioxide coating and its potential to Induce changes in adaptive resistance
... expression (Martin & Rosner, 1995). When inducers like salicylate and other phenolic compounds are present, MarR binds to them and is then unable to bind to the marRAB promoter (Cohen et al., 1993). Copper has been ...
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Neuropilin 1 upregulation elicits adaptive resistance to oncogene targeted therapies
... full adaptive resistance. The relevance of NRP1 in drug resistance was ultimately demonstrated in vivo by treating mice bearing tumor xenografts of drug-resistant A375 melanoma cells, subjected to ...
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Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis
... bladder, colon, prostate and lung cancer cells. In this study, high doses of IR (4 Gy) induced cell death; nevertheless, a previous study showed that sub-lethal doses of IR (2, 10, 50 or 100 cGy) induced NFκB activation ...
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Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state
... In this paper, we monitor the responses of BRAF V600E melanoma cells to vemurafenib in real time using live-cell imaging and then analyze the resulting cell states using molecular and phenotypic pro- filing. We find that ...
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Adaptive Resistance in Bacteria Requires Epigenetic Inheritance, Genetic Noise, and Cost of Efflux Pumps
... In this study we present a theoretical framework that identifies the essential mechanisms for the emergence, evolution and reversibility of adaptive resistance. We constructed a single-cell dynamic model of ...
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Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms
... Constitutively activated signaling molecules are often the primary drivers of malignancy, and are favored targets for therapeutic intervention. However, the effectiveness of targeted inhibition of cell signaling can be ...
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Adaptive Resistance to Biocides in Salmonella enterica and Escherichia coli O157 and Cross Resistance to Antimicrobial Agents
... of adaptive resistance to ERY, BKC, CHX, and TLN was investigated by passage of the adapted cells in non- selective ...that adaptive tolerance to ERY is subject to minor variability but remains ...
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BET bromodomain inhibitor birabresib in mantle cell lymphoma: in vivo activity and identification of novel combinations to overcome adaptive resistance
... (A) Distribution of Chou-Talalay Combination Index (C.I.) values obtained in one birabresib- sensitive (Jeko1) and in one birabresib poor-sensitivity lymphoma cell line (Granta519), trea[r] ...
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Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA)
... immune adaptive resistance, the TIS may provide additional utility in the context of mutation load, which is measuring potentially immune activat- ing neoantigen expression, to enrich for clinical re- ...
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Adaptive and Acquired Resistance to EGFR Inhibitors Converge on the MAPK Pathway
... characterize adaptive resistance associated with EGFR ...the adaptive reactivation of MAPK pathway may limit initial EGFR TKI response, reminiscent of recent findings using irreversible EGFR ...
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Evaluating adaptive authoring of adaptive hypermedia
... of adaptive systems, but still, a lot less targets the complex task of authoring of such systems, or their ...generic Adaptive Hypermedia authoring environment, MOT, into a semantic desktop environment, ...
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Presence of the Potato Late Blight Resistance Gene RB Does Not Promote Adaptive Parasitism of Phytophthora infestans
... (i.e. resistance breaking) such as has been observed in some isolates of ...overcome resistance is associated with the absence of class I or the presence of class III IPI-O variants ...
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Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans
... ABSTRACT Regulated erroneous protein translation (adaptive mistranslation) in- creases proteome diversity and produces advantageous phenotypic variability in the human pathogen Candida albicans. It also increases ...
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FOREARM METABOLISM IN OBESITY AND ITS RESPONSE TO INTRA ARTERIAL INSULIN CHARACTERIZATION OF INSULIN RESISTANCE AND EVIDENCE FOR ADAPTIVE HYPERINSULINISM
... Forearm skin and subcutaneous tissue metabolism Mean values for basal arterio-superficial venous A-SV concentration differences of glucose, lactate, potassium, and FFA in the six obese s[r] ...
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The adaptive stroma joining the antiangiogenic resistance front
... Resistance to antiangiogenic therapies in cancer involves both tumor cells and stromal components, but their relative contributions differ in each cancer subtype. In this issue of the JCI, Cascone et al. describe ...
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Adaptive and non-adaptive divergence in a common landscape
... between adaptive evolution, gene flow and genetic drift 5 ...that adaptive evolution may have a measurable impact on population and community dynamics (see above), such a shift in population density of a ...
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A spiral model for adding automatic, adaptive authoring to adaptive hypermedia
... Previously, in [Hendrix et al., 06], we described the interaction and exchange of data between the Beagle++ environment [Beagle, 08], [Chirita et al., 06], which is an advanced search and indexing engine for the semantic ...
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Adaptive SPSA_Mar2020_handout.pdf
... • Spall, J. C. (2009), “Feedback and Weighting Mechanisms for Improving Jacobian Estimates in the Adaptive Simultaneous Perturbation Algorithm,” IEEE Trans. on Auto. Control, vol. 54(6), pp. 1216–1229. ...
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