Adaptor Proteins
Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation
... Failure of trabecular myocytes to undergo appropriate cell cycle withdrawal leads to ventricular noncompaction and heart failure. Signaling of growth factor receptor ERBB2 is critical for myocyte proliferation and ...
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Biophysical analysis of binding interactions between clathrin and its adaptor proteins
... different adaptor/accessory proteins. A large number of different adaptor and accessory proteins are recruited during CME, in a spatially and temporally ordered ...individual adaptor ...
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A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk like in zebrafish myoblast fusion
... CDM proteins form part of multiple signalling pathways, the best-characterised being the Crk-CDM-Rac pathway, we have also used our assay to investigate a postulated role for the adaptor proteins Crk ...
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The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma
... Previous findings have indicated that the adaptor protein Tks5 regulates melanoma invasiveness in vitro [14, 16]. However, the role of Tks4 in cancer cells has not previously been addressed. In the present study, ...
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A dimer of the Toll like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
... These adaptor pairs couple two distinct signalling pathways leading to the activation of interferon response factor 3 (IRF-3) and nuclear factor kB (NFkB) ...and adaptor TIR ...
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Crk adaptor proteins act as key signaling integrators for breast tumorigenesis
... Crk adaptor proteins in epithelial derived breast can- cers and their correlation to human clinical parameters in vivo is poorly ...Crk proteins in human breast cancer using TMAs (n = 254), revealing ...
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A new role for clathrin adaptor proteins 1 and 3 in lipoplex trafficking
... clathrin adaptor proteins in the sorting and trafficking of protein cargo between compartments such as the trans-Golgi network (TGN), endosomes, lysosomes, plasma ...membrane. Adaptor proteins ...
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Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release
... host adaptor proteins (APs) AP-1A, AP-1B, and AP-4 traffic in post-Golgi compart- ments, and the latter two are implicated in basolateral ...endocytic adaptor AP-2 mediates entry and ...
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Expression of signaling adaptor proteins predicts poor prognosis in pancreatic ductal adenocarcinoma
... Adaptor proteins are the bridging elements that con- nect the membrane-docking RTKs and downstream signal components in the ...ability, adaptor proteins are divided into two ...of ...
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Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection
... IPS-1 adaptor proteins, re- spectively, implicated in TLR3 and RLH signaling pathways, was investigated during herpes simplex virus 1 (HSV-1) encephali- ...
8
Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation
... Background: Signalling by the T cell antigen receptor (TCR) results in the activation of T lymphocytes. Nck1 and Nck2 are two highly related adaptor proteins downstream of the TCR that each contains three ...
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Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency
... the adaptor proteins CIN85 and Abi-1 as host proteins interacting with pUL135 using two complementary screens to identify interacting ...multifunctional adaptor protein with roles in ...
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Experimental research on the relationship between the stiffness and the expressions of fibronectin proteins and adaptor proteins of rat trabecular meshwork cells
... Here we explicitly note that from one point of view, clinical drug treatment can change the IOP. In steroid- induced glaucoma, ECM component synthesis is in- creased and is associated with elevated IOP. Studies have ...
9
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
... Once extended, the central region of p130Cas is a sub- strate for activated tyrosine kinases, and p130Cas itself has binding sites for FAK [106] and Pyk2 [107] (via the SH3 domain) and SFK members through the C-terminal ...
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Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK 1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7
... scaffold proteins TANK, NAP1 (NAK-associated protein 1) or SINTBAD (similar to NAP1 TBK1 adaptor) ...the adaptor protein MAVS (mitochondrial antiviral signalling) [19–21], other intracellular DNA ...
15
PubMedCentral-PMC4798554.pdf
... (IRS) adaptor proteins are necessary for linking IGF1R to downstream signaling pathways and the malignant phenotype in breast cancer ...IRS adaptor specific and primary ...IRS proteins was ...
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Implicating Receptor Activator of NF-κB (RANK)/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli
... In this study, we showed a possible mechanism for the regulation of the microglial responses to LPS and Poly I:C by the RANKL/RANK pathway. We propose that there is an antagonistic relationship between TLR3/TLR4 signal- ...
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Kinetic Monte Carlo Study of the Type 1/Type 2 Choice in Apoptosis Elucidates Selective Killing of Cancer Cells under Death Ligand Induction
... death adaptor proteins and cFLIP was taken to be 30 (unless stated otherwise) [27] [32] [34], which is comparable to the expression level of pro-caspase 8 molecules used in our ...
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Delineation of the TRAK binding regions of the kinesin 1 motor proteins
... Interestingly, the KIF5A TRAK1 binding site was shown to be distinct to that of TRAK2 suggesting a differential interaction be- tween these two kinesin adaptor proteins and molecular motors which may impact ...
8
Lange, Anika (2010): Genetic analysis of the catalytic activity of Integrin-linked kinase (ILK) in vivo. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Nephrin, podocin and CD2AP are considered as the main structural elements of the SD. Nephrin is a single-pass transmembrane protein that homodimerizes and forms heterodimers with its homolog NEPH1, thus connecting ...
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