adenine nucleotide
The product of the Herpes simplex virus 1 UL7 gene interacts with a mitochondrial protein, adenine nucleotide translocator 2
... The herpes simplex virus 1 (HSV-1) UL7 gene is highly conserved among herpesviridae. Since the construction of recombinant HSV-1 with a mutation in the UL7 gene has not been reported, the involvement of HSV-1 UL7 in ...
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Beta adrenergic stimulation of adenine nucleotide catabolism and purine release in human adipocytes
... cyclic nucleotide and/or involvement of the hormone-sensitive, low Km cAMP ...of adenine nucleotide catabolism in the presence of beta-adrenergic ...
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Ethanol induced activation of adenine nucleotide turnover Evidence for a role of acetate
... [8-14C] adenine increased to 171 +/- 27% and to 128 +/- 8% of the base-line values after acetate and ethanol ...purine nucleotide degradation by enhancing the turnover of the adenine ...
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stress sensitive B Encodes an Adenine Nucleotide Translocase in Drosophila melanogaster
... second adenine nucleotide translocase-like gene is its 59 UTR (Figure ...encoding adenine nucleotide translocase in positions identical to those within the coding sequence ...
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The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase
... catalyzed by hexokinase and cancer cells mostly employ an isoform (HKII) that is bound to mitochondria via interaction with the outer-membrane voltage dependent anion channel (VDAC) [2-5]. VDAC is associated with ...
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A Temperature-Sensitive Allele of Drosophila sesB Reveals Acute Functions for the Mitochondrial Adenine Nucleotide Translocase in Synaptic Transmission and Dynamin Regulation
... mitochondrial adenine nucleotide translocase (ANT) and results in a unique ts paralytic behavior that is accompanied by a complete loss of synaptic transmission in the visual ...
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Characterization of the Intracellular Distribution of Adenine Nucleotide Translocase (ANT) in Drosophila Indirect Flight Muscles
... Background: The high power output necessary for insect flight has driven the evolution of muscles with large myofi- brils (primary energy consumers) and abundant mitochondria (primary energy suppliers). The intricate ...
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Biochemical energetics of simulated platelet plug formation: Effect of thrombin, adenosine diphosphate, and epinephrine on intra and extracellular adenine nucleotide kinetics
... Washed human platelets were incubated in a modified Ringer's solution, pH 7.1, at 37°C for 1 hr. Intracellular basal levels for glycogen, adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate ...
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The platelet defect in leukemia Platelet ultrastructure, adenine nucleotide metabolism, and the release reaction
... and adenine nucleotide metabolism of platelets from patients with acute leukemia were studied to elucidate possible mechanisms for the platelet dysfunction observed in this clinical ...
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Pathways of adenine nucleotide catabolism in erythrocytes
... the adenine nucleotides proceeded by way of a dephosphorylation of AMP followed by deamination of adenosine, and a small recycling of this nucleoside could be ...
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Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor
... However, mitochondrial membrane permeability ∆Ψm, cytochrome c release, caspase-9 cleavage, and caspase-3 cleavage and activity were all reduced by NFV pretreatment Figure 3, B–E, which [r] ...
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Allopurinol enhanced adenine nucleotide repletion after myocardial ischemia in the isolated rat heart
... allopurinol could restore adenosine triphosphate (ATP) levels and improve the recovery of left ventricular function after global myocardial ischemia. Hearts were equilibrated for 30 min, subjected to 10 min of global, ...
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Adenine nucleotide translocation in rat liver mitochondria : calcium stimulation and the involvement of phospholipids
... The observation that a there are two different types of binding sites for either ATP or ADP in mitochondria 267, Section D, and b the translocation process exhibits both a high and a low[r] ...
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Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets
... AD: Alzheimer ’ s disease; ANT: Adenine nucleotide translocator; DS: Down Syndrome; DS-HFFs: Human fibroblasts from Down syndrome fetuses; Hsa21: Chromosome 21; mPTP: mitochondrial perme[r] ...
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Programmed cell death and its role in inflammation
... ANT: Adenine nucleotide translocase; BAI: Brain-specific angiogenesis inhibitor; CARD: Caspase activation and recruitment domains; CLP: Cecal ligation and puncture; COPD: Chronic obstructive pulmonary ...
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Dysfunction of various organelles provokes multiple cell death after quantum dot exposure
... ANT, adenine nucleotide transporter; ATF4, activating transcription factor 4; ATF6, activating transcription factor 6; Bak, Bcl-2 antagonist/killer 1; Bax, Bcl-2-associated X protein; Bcl-2, B-cell ...
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Effects of hypoxia–cadmium interactions on rainbow trout (Oncorhynchus mykiss) mitochondrial bioenergetics: attenuation of hypoxia induced proton leak by low doses of cadmium
... 13,000 g pellet mitochondrial fraction 13,000 g supernatant cytosolic fraction adenine nucleotide translocase cadmium citrate synthase 2,6-dichlorophenol indophenol 2,4-dinitrophenol 5,5[r] ...
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Purine nucleotides and their metabolites in patients with type 1 and 2 diabetes mellitus
... bolism in diabetes. It has been reported that increased Ado concentration increases the concentration of adenine nucleotides in erythrocytes [23]. Komarova et al. [24] observed an increase in ATP and TAN after ...
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Mitochondrial plasticity in the cerebellum of two anoxia tolerant sharks: contrasting responses to anoxia/re oxygenation
... apparent Km for succinate adenine nucleotide translocase anoxia/re-oxygenation carboxy-atractyloside carbonyl cyanide m-chlorophyll hydrazine mitochondrial complex I mitochondrial comple[r] ...
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Metabolic and circulatory limitations to muscular performance at the organ level
... This loss in adenine nucleotide content is dependent on the severity of the contraction conditions relative to the functional aerobic capacity of the muscle fibre, since fast-twitch red [r] ...
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